Differences of aberrant dynamic functional connectivity between depressed patients with and without suicidal ideation
Authors: 
Jiao Li, Bing Li, Yao Meng, Siqi Yang, Huafu Chen, Wei LiaoAuthors Info & Claims
Pages 145 - 150
Abstract
Major depressive disorder (MDD) has been associated with dynamic functional changes in the brain. However, little is known regarding the different dysfunctions of dynamic functional connectivity (dFC) in MDD patients with and without suicidal ideation. Several studies linked rostral anterior cingulate cortex (rACC) to suicide. The purpose of this study was to investigate the distinct dysfunctions of rACC-based dFC in MDD patients with and without suicidal ideation. Participants consisted of 28 MDD patients with suicidal ideation (SI), 20 MDD patients without suicidal ideation (NSI), and 30 ethically matched healthy controls (HC). The rACC-based dFC was analyzed among the three groups. We found that SI group exhibited increased iFC between the rACC and left lingual gyrus (LING) and right middle temporal gyrus (MTG) compared to HC and NSI groups. The decreased dFC between rACC and right MTG was found in NSI compared to HC. In addition, the connectivity variability between rACC and LING was positively correlated with severity of suicidal ideation (SSI) in SI group. Importantly, the aberrant dFC values yielded 79% accuracy with 86% sensitivity and 70% specificity in differentiating between SI and NSI. Disrupted transdiagnostic and diagnosis-specific regions are part of neural circuitries that mediate emotional and visual perceptions. In particular, aberrant rACC-based dFC values might be as classification features in distinguishing SI from NSI, and the dFC between rACC and left LING might be a predictor of SSI in MDD patients.
References
[1]
Kupfer DJ, Frank E, Phillips ML (2012): Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet 379:1045-1055.
[2]
Collaborators GDaIIaP (2016): Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 388:1545-1602.
[3]
Brådvik L, Mattisson C, Bogren M, Nettelbladt P (2008): Long‐term suicide risk of depression in the Lundby cohort 1947–1997–severity and gender. Acta Psychiatrica Scandinavica 117:185-191.
[4]
Boes AD, McCormick LM, Coryell WH, Nopoulos P (2008): Rostral anterior cingulate cortex volume correlates with depressed mood in normal healthy children. Biol Psychiatry 63:391-397.
[5]
Wagner G, Koch K, Schachtzabel C, Schultz CC, Sauer H, Schlosser RG (2011): Structural brain alterations in patients with major depressive disorder and high risk for suicide: evidence for a distinct neurobiological entity? Neuroimage 54:1607-1614.
[6]
Myung W, Han CE, Fava M, Mischoulon D, Papakostas GI, Heo JY, (2016): Reduced frontal-subcortical white matter connectivity in association with suicidal ideation in major depressive disorder. Transl Psychiatry 6:e835.
[7]
Du L, Zeng J, Liu H, Tang D, Meng H, Li Y, (2017): Fronto-limbic disconnection in depressed patients with suicidal ideation: A resting-state functional connectivity study. J Affect Disord 215:213-217.
[8]
Li J, Duan X, Cui Q, Chen H, Liao W (2019): More than just statics: temporal dynamics of intrinsic brain activity predicts the suicidal ideation in depressed patients. Psychol Med 49:852-860.
[9]
Liao W, Li J, Duan X, Cui Q, Chen H, Chen H (2018): Static and dynamic connectomics differentiate between depressed patients with and without suicidal ideation. Hum Brain Mapp 39:4105-4118.
[10]
Allen EA, Damaraju E, Plis SM, Erhardt EB, Eichele T, Calhoun VD (2014): Tracking whole-brain connectivity dynamics in the resting state. Cereb Cortex 24:663-676.
[11]
Kaiser RH, Whitfield-Gabrieli S, Dillon DG, Goer F, Beltzer M, Minkel J, (2016): Dynamic Resting-State Functional Connectivity in Major Depression. Neuropsychopharmacology 41:1822-1830.
[12]
Braun U, Schafer A, Bassett DS, Rausch F, Schweiger JI, Bilek E, et al. (2016): Dynamic brain network reconfiguration as a potential schizophrenia genetic risk mechanism modulated by NMDA receptor function. P Natl Acad Sci USA 113:12568-12573.
[13]
Liao W, Zhang Z, Mantini D, Xu Q, Ji GJ, Zhang H, et al. (2014): Dynamical intrinsic functional architecture of the brain during absence seizures. Brain Struct Funct 219:2001-2015.
[14]
Kim J, Criaud M, Cho SS, Diez-Cirarda M, Mihaescu A, Coakeley S, et al. (2017): Abnormal intrinsic brain functional network dynamics in Parkinson's disease. Brain 140:2955-2967.
[15]
Beck AT, Kovacs M, Weissman A (1979): Assessment of suicidal intention: the Scale for Suicide Ideation. J Consult Clin Psychol 47:343-352.
[16]
Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE (2012): Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage 59:2142-2154.
[17]
van Heeringen K, Bijttebier S, Desmyter S, Vervaet M, Baeken C (2014): Is there a neuroanatomical basis of the vulnerability to suicidal behavior? A coordinate-based meta-analysis of structural and functional MRI studies. Frontiers in Human Neuroscience 8.
[18]
Etkin A, Egner T, Kalisch R (2011): Emotional processing in anterior cingulate and medial prefrontal cortex. Trends Cogn Sci 15:85-93.
[19]
Liao W, Wu GR, Xu Q, Ji GJ, Zhang Z, Zang YF, et al. (2014): DynamicBC: A MATLAB toolbox for dynamic brain connectome analysis. Brain Connect 4:780-790.
[20]
Leonardi N, Van De Ville D (2015): On spurious and real fluctuations of dynamic functional connectivity during rest. Neuroimage 104:430-436.
[21]
Jung J, Kang J, Won E, Nam K, Lee MS, Tae WS, et al. (2014): Impact of lingual gyrus volume on antidepressant response and neurocognitive functions in Major Depressive Disorder: a voxel-based morphometry study. J Affect Disord 169:179-187.
[22]
Zhang S, Chen JM, Kuang L, Cao J, Zhang H, Ai M, et al. (2016): Association between abnormal default mode network activity and suicidality in depressed adolescents. BMC Psychiatry 16:337.
[23]
Giakoumatos CI, Tandon N, Shah J, Mathew IT, Brady RO, Clementz BA, et al. (2013): Are structural brain abnormalities associated with suicidal behavior in patients with psychotic disorders? J Psychiatr Res 47:1389-1395.
[24]
Morawetz C, Bode S, Baudewig J, Jacobs AM, Heekeren HR (2016): Neural representation of emotion regulation goals. Hum Brain Mapp 37:600-620.
[25]
Ma C, Ding J, Li J, Guo W, Long Z, Liu F, et al. (2012): Resting-state functional connectivity bias of middle temporal gyrus and caudate with altered gray matter volume in major depression. PLoS One 7:e45263.
[26]
Willeumier K, Taylor DV, Amen DG (2011): Decreased cerebral blood flow in the limbic and prefrontal cortex using SPECT imaging in a cohort of completed suicides. Transl Psychiatry 1:e28.
[27]
van Heeringen C, Bijttebier S, Godfrin K (2011): Suicidal brains: a review of functional and structural brain studies in association with suicidal behaviour. Neurosci Biobehav Rev 35:688-698.
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Published In
December 2020
239 pages
ISBN:9781450389686
DOI:10.1145/3451421
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Published: 27 August 2021
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- Research-article
- Research
- Refereed limited
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- Sichuan Science and Technology Program
- National Natural Science Foundation of China
- National Key Project of Research and Development
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ISICDM 2020
ISICDM 2020: The Fourth International Symposium on Image Computing and Digital Medicine
December 5 - 7, 2020
Shenyang, China
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