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An Efficient Method of Histological Cell Image Detection Based on Spatial Information Convolution Neural Network

Published: 25 February 2020 Publication History

Abstract

As an important research direction in the field of medical images, histopathological cell image detection has been widely used in computer-aided diagnosis, biological research fields. With the rise of deep learning, neural network is applied to medical image analysis, which can realize the automatic detection and classification of histological cell images. In order to solve the problem that the output of the existing neural network is affected by spatial information factors in its topological domain, on the basis of the traditional convolution neural network. Combined with the spatial position information, an improved convolution neural network model for histological cell image detection is proposed. Taking the traditional convolution neural network as the carrier, the convolution neural network model based on spatial information is constructed, which makes the model has the ability to fuse spatial information and eigenvector. Histopathological cell images were preprocessed by color deconvolution. Finally, a model verification experiment based on colorectal cancer image dataset is designed. The model proposed in this paper shows better performance than the state-of-the-art methods in four different categories (more than 20000 experimental images): the experimental accuracy is 75.8%, and the recall rate is 82.3%. F1 reached 80.1%.

References

[1]
Xu J, Xiang L, Liu Q, et al. 2016. Stacked Sparse Autoencoder (SSAE) for Nuclei Detection on Breast Cancer Histopathology Images [J]. IEEE Transactions on Medical Imaging, 35, 1.
[2]
Yuan Y, Failmezger H, Rueda O M, et al.2012. Quantitative image analysis of cellular heterogeneity in breast tumors complements genomic profiling [J]. Science translational medicine, 4(157): 157ra143--157ra143.
[3]
Cosatto E, Miller M, Graf H P, et al. 2008. Grading nuclear pleomorphism on histological micrographs[C]//2008 19th International Conference on Pattern Recognition. IEEE, 2008: 1--4.
[4]
Al-Kofahi Y, Lassoued W, Lee W, et al. 2009. Improved automatic detection and segmentation of cell nuclei in histopathology images [J]. IEEE Transactions on Biomedical Engineering, 57(4): 841--852.
[5]
Kuse M, Wang Y F, Kalasannavar V, et al. 2011. Local isotropic phase symmetry measure for detection of beta cells and lymphocytes [J]. Journal of pathology informatics, 2.
[6]
Veta M, Van Diest P J, Kornegoor R, et al. 2013. Automatic nuclei segmentation in H&E stained breast cancer histopathology images [J]. PloS one, 8(7): e70221.
[7]
Arteta C, Lempitsky V, Noble J A, et al. 2012. Learning to detect cells using non-overlapping extremal regions [C]//International Conference on Medical Image Computing and Computer-Assisted Intervention. Springer, Berlin, Heidelberg, 348--356.
[8]
Ali S, Madabhushi A. 2012. An integrated region-, boundary-, shape-based active contour for multiple object overlap resolution in histological imagery [J]. IEEE transactions on medical imaging, 31(7): 1448--1460.
[9]
Vink J P, Van Leeuwen M B, Van Deurzen C H M, et al. 2013. Efficient nucleus detector in histopathology images [J]. Journal of microscopy, 249(2): 124--135.
[10]
Xie Y, Xing F, Kong X, et al. 2015. Beyond classification: structured regression for robust cell detection using convolutional neural network [C]//International Conference on Medical Image Computing and Computer-Assisted Intervention. Springer, Cham, 358--365.
[11]
Xie Y, Kong X, Xing F, et al. 2015. Deep voting: A robust approach toward nucleus localization in microscopy images [C]//International Conference on Medical Image Computing and Computer-Assisted Intervention. Springer, Cham, 374--382.
[12]
A. M. Khan, N.Rajpoot, D. Treanor, and D. Magee. 2014. A nonlinear mapping approach to stain normalization in digital histopathology images using image-specific color deconvolution [J]. IEEE Trans. Biomed. Eng., vol. 61, no. 6, pp. 1729--1738.

Cited By

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  • (2022)Automatic detection of three cell types in a microscope image based on deep learningJournal of Biophotonics10.1002/jbio.20220013215:11Online publication date: 22-Aug-2022
  • (2021)System for quantitative evaluation of DAB&H-stained breast cancer biopsy digital images (CHISEL)Scientific Reports10.1038/s41598-021-88611-y11:1Online publication date: 29-Apr-2021

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  1. An Efficient Method of Histological Cell Image Detection Based on Spatial Information Convolution Neural Network

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    ICVIP '19: Proceedings of the 3rd International Conference on Video and Image Processing
    December 2019
    270 pages
    ISBN:9781450376822
    DOI:10.1145/3376067
    Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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    • Shanghai Jiao Tong University: Shanghai Jiao Tong University
    • Xidian University
    • TU: Tianjin University

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    Association for Computing Machinery

    New York, NY, United States

    Publication History

    Published: 25 February 2020

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    Author Tags

    1. Cell nuclei detection
    2. Convolutional neural network
    3. Spatial information

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    Cited By

    View all
    • (2022)Automatic detection of three cell types in a microscope image based on deep learningJournal of Biophotonics10.1002/jbio.20220013215:11Online publication date: 22-Aug-2022
    • (2021)System for quantitative evaluation of DAB&H-stained breast cancer biopsy digital images (CHISEL)Scientific Reports10.1038/s41598-021-88611-y11:1Online publication date: 29-Apr-2021

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