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On the assessment of microfluidic switching capabilities in NLoC networks

Published: 06 May 2014 Publication History

Abstract

Microfluidic devices have recently attracted the interest of researchers for the number of applications especially in healthcare and controlled drug delivery. However these devices are today not programmable and static in the sense that they perform simple and fixed operations which cannot be changed during device's functioning. To overcome the limitations of traditional microfluidic devices, we have recently proposed the idea of supporting dynamic addressing of different microfluidic elements able to execute various tasks by introducing basic communication and networking functionalities in the microfluidic domain. To enable this vision, we have designed a passive switching device for droplets - that we call microfluidic switch - in which the path followed by a droplet in a microfluidic network can be controlled across a series of junctions, by simply modulating the distance between droplets in the microfluidic channel. In this paper, an experimental testing of a microfluidic switch is presented and compared with results obtained from numerical simulations.

References

[1]
A. R. Abate, J. J. Agresti, and D. A. Weitz. Microfluidic sorting with high-speed single-layer membrane valves. Applied Physics Letters, 96:203509, 2010.
[2]
J. J. Agresti, E. Antipov, A. R. Abate, K. Ahn, A. C. Rowat, J.-C. Baret, M. Marquez, A. M. Klibanov, A. D. Griffiths, and D. A. Weitz. Ultrahigh-throughput screening in drop-based microfluidics for directed evolution. Proceedings of the National Academy of Sciences of the United States of America, 107:4004--4009, 2010.
[3]
C. N. Baroud, J.-P. Delville, F. m. c. Gallaire, and R. Wunenburger. Thermocapillary valve for droplet production and sorting. Phys. Rev. E, 75, 2007.
[4]
H. Bruus. Theoretical Microfluidics. Oxford Master In Condensed Matter Physics. Oxford University Press, 2007.
[5]
M. A. Cartas-Ayala, M. Raafat, and R. Karnik. Self-sorting of deformable particles in an asynchronous logic microfluidic circuit. Small, 9:166--188, 2012.
[6]
L. F. Cheow, L. Yobas, and D.-L. Kwong. Digital microfluidics: Droplet based logic gates. Applied Physics Letters, 90, 2007.
[7]
G. Cristobal, J.-P. Benoit, M. Joanicot, and A. Ajdari. Microfluidic bypass for efficient passive regulation of droplet traffic at a junction. Applied Physics Letters, 89, 2006.
[8]
O. Cybulski and P. Garstecki. Dynamic memory in a microfluidic system of droplets traveling through a simple network of microchannels. Lab Chip, 10:484--493, 2010.
[9]
E. De Leo, L. Donvito, L. Galluccio, G. Morabito, A. Lombardo, and L. M. Zanoli. Communications and switching in microfluidic systems: Pure hydrodynamic control for networking Labs-on-a-Chip. To Appear in IEEE Transactions on Communications, 2013.
[10]
E. De Leo, L. Galluccio, A. Lombardo, and G. Morabito. Networked labs-on-a-chip (nloc): Introducing networking technologies in microfluidic systems. Nano Communication Networks, 3(4), 2012.
[11]
W. Engl, M. Roche, A. Colin, P. Panizza, and A. Ajdari. Droplet traffic at a simple junction at low capillary numbers. Phys. Rev. Lett., 95, 2005.
[12]
T. Franke, A. R. Abate, D. A. Weitz, and A. Wixforth. Surface acoustic wave (saw) directed droplet flow in microfluidics for pdms devices. Lab Chip, 9:2625--2627, 2009.
[13]
M. J. Fuerstman, P. Garstecki, and G. M. Whitesides. Coding/decoding and reversibility of droplet trains in microfluidic networks. Science, 315:828--832, 2007.
[14]
H. Gu, C. U. Murade, M. H. G. Duits, and F. Mugele. A microfluidic platform for on-demand formation and merging of microdroplets using electric control. Biomicrofluidics, 5:011101, 2011.
[15]
Z. Han, W. Li, Y. Huang, and B. Zheng. Measuring rapid enzymatic kinetics by electrochemical method in droplet-based microfluidic devices with pneumatic valves. Analytical Chemistry, 81:5840--5845, 2009. 19518139.
[16]
A. C. Hatch, A. A. Patel, N. R. Beer, and A. Lee. Passive droplet sorting using viscoelastic flow focusing. Lab Chip, 2013.
[17]
B. Kintses, L. D. Van Vliet, S. R. A. Devenish, and F. Hollfelder. Microfluidic droplets: new integrated workflows for biological experiments. Current Opinion in Chemical Biology, 14:548--555, 2010.
[18]
D. R. Link, S. L. Anna, D. A. Weitz, and H. A. Stone. Geometrically mediated breakup of drops in microfluidic devices. Phys. Rev. Lett., 92, 2004.
[19]
D. R. Link, E. Grasland-Mongrain, A. Duri, F. Sarrazin, Z. Cheng, G. Cristobal, M. Marquez, and D. A. Weitz. Electric control of droplets in microfluidic devices. Angewandte Chemie International Edition, 45:2556--2560, 2006.
[20]
W. Liu, H. J. Kim, E. M. Lucchetta, W. Du, and R. F. Ismagilov. Isolation, incubation, and parallel functional testing and identification by fish of rare microbial single-copy cells from multi-species mixtures using the combination of chemistrode and stochastic confinement. Lab Chip, 9:2153--2162, 2009.
[21]
OpenFOAM. The Open Source CFD Toolbox, user guide, 2012.
[22]
M. Prakash and N. Gershenfeld. Microfluidic bubble logic. Science, 315(5813), February 2007.
[23]
D. A. Sessoms, A. Amon, L. Courbin, and P. Panizza. Complex dynamics of droplet traffic in a bifurcating microfluidic channel: Periodicity, multistability, and selection rules. Phys. Rev. Lett., 105:154501, Oct 2010.
[24]
D. A. Sessoms, M. Belloul, W. Engl, M. Roche, L. Courbin, and P. Panizza. Droplet motion in microfluidic networks: Hydrodynamic interactions and pressure-drop measurements. Phys. Rev. E, 80, 2009.
[25]
H. Song, H.-W. Li, M. S. Munson, T. G. Van Ha, and R. F. Ismagilov. On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system. Analytical Chemistry, 78:4839--4849, 2006.
[26]
Y.-C. Tan, J. S. Fisher, A. I. Lee, V. Cristini, and A. P. Lee. Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting. Lab Chip, 4:292--298, 2004.
[27]
Y.-C. Tan, Y. L. Ho, and A. P. Lee. Microfluidic sorting of droplets by size. Microfluidics and Nanofluidics, 4:343--348, 2008.
[28]
S.-Y. Teh, R. Lin, L.-H. Hung, and A. P. Lee. Droplet microfluidics. Lab Chip, 8:198--220, 2008.
[29]
C.-G. Yang, Z.-R. Xu, and J.-H. Wang. Manipulation of droplets in microfluidic systems. TrAC Trends in Analytical Chemistry, 29:141--157, 2010.
[30]
L. M. Zanoli, M. Licciardello, R. D'Agata, C. Lantano, A. Calabretta, R. Corradini, R. Marchelli, and G. Spoto. Peptide nucleic acid molecular beacons for the detection of pcr amplicons in droplet-based microfluidic devices. Analytical and Bioanalytical Chemistry, 2012.

Cited By

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  • (2021)Practical Assessment of Payload- Header Switching in Microfluidic NetworksProceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication10.1145/3477206.3477451(1-6)Online publication date: 17-Sep-2021
  • (2019)Automatic Design of Microfluidic Devices: An Overview of Platforms and Corresponding Design TasksLanguages, Design Methods, and Tools for Electronic System Design10.1007/978-3-030-31585-6_4(71-87)Online publication date: 21-Dec-2019
  • (2018)IntroductionExact Design of Digital Microfluidic Biochips10.1007/978-3-319-90936-3_1(1-9)Online publication date: 12-Jun-2018
  • Show More Cited By

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      cover image ACM Other conferences
      NANOCOM' 14: Proceedings of ACM The First Annual International Conference on Nanoscale Computing and Communication
      May 2014
      194 pages
      ISBN:9781450329798
      DOI:10.1145/2619955
      Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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      Published: 06 May 2014

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      View all
      • (2021)Practical Assessment of Payload- Header Switching in Microfluidic NetworksProceedings of the Eight Annual ACM International Conference on Nanoscale Computing and Communication10.1145/3477206.3477451(1-6)Online publication date: 17-Sep-2021
      • (2019)Automatic Design of Microfluidic Devices: An Overview of Platforms and Corresponding Design TasksLanguages, Design Methods, and Tools for Electronic System Design10.1007/978-3-030-31585-6_4(71-87)Online publication date: 21-Dec-2019
      • (2018)IntroductionExact Design of Digital Microfluidic Biochips10.1007/978-3-319-90936-3_1(1-9)Online publication date: 12-Jun-2018
      • (2017)Verification of networked labs-on-chip architecturesProceedings of the Conference on Design, Automation & Test in Europe10.5555/3130379.3130772(1683-1688)Online publication date: 27-Mar-2017
      • (2017)A Discrete Model for Networked Labs-on-ChipsProceedings of the 54th Annual Design Automation Conference 201710.1145/3061639.3062186(1-6)Online publication date: 18-Jun-2017

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