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Enhanced Random Forest for Mitosis Detection

Published: 14 December 2014 Publication History

Abstract

Histopathological grading of cancer is a measure of the cell appearance in malignant neoplasms. Grading offers an insight to the growth of the cancer and helps in developing individual treatment plans. The Nottingham grading system [12], well known method for invasive breast cancer grading, primarily relies on the mitosis count in histopathological slides. Pathologists manually identify mitotic figures from a few thousand slide images for each patient to determine the grade of the cancer. Mitotic figures are hard to identify as the appearance of the mitotic cells change at different phases of mitosis. So, the manual cancer grading is not only a tedious job but also prone to observer variability. We propose a fast and accurate approach for automatic mitosis detection from histopathological images using an enhanced random forest classifier with weighted random trees. The random trees are assigned a tree penalty and a forest penalty depending on their classification performance at the training phase. The weight of a tree is calculated based on these penalties. The forest is trained through regeneration of population from weighted trees. The input data is classified based on weighted voting from the random trees after several populations. Experiments show at least 11 percent improvement in F1 score on more than 450 histopathological images at ×40 magnification.

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Cited By

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  • (2020)M-ary Random Forest - A new multidimensional partitioning approach to Random ForestMultimedia Tools and Applications10.1007/s11042-020-10047-9Online publication date: 30-Oct-2020
  • (2019)Exponentially Weighted Random ForestPattern Recognition and Machine Intelligence10.1007/978-3-030-34869-4_19(170-178)Online publication date: 25-Nov-2019
  • (2017)Computational approach for mitotic cell detection and its application in oral squamous cell carcinomaMultidimensional Systems and Signal Processing10.1007/s11045-017-0488-628:3(1031-1050)Online publication date: 1-Jul-2017
  • Show More Cited By

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Published In

cover image ACM Other conferences
ICVGIP '14: Proceedings of the 2014 Indian Conference on Computer Vision Graphics and Image Processing
December 2014
692 pages
ISBN:9781450330619
DOI:10.1145/2683483
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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Association for Computing Machinery

New York, NY, United States

Publication History

Published: 14 December 2014

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Author Tags

  1. Breast cancer grading
  2. Forest Penalty
  3. Random Forest
  4. Tree penalty
  5. Weighted voting

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ICVGIP '14

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Overall Acceptance Rate 95 of 286 submissions, 33%

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Cited By

View all
  • (2020)M-ary Random Forest - A new multidimensional partitioning approach to Random ForestMultimedia Tools and Applications10.1007/s11042-020-10047-9Online publication date: 30-Oct-2020
  • (2019)Exponentially Weighted Random ForestPattern Recognition and Machine Intelligence10.1007/978-3-030-34869-4_19(170-178)Online publication date: 25-Nov-2019
  • (2017)Computational approach for mitotic cell detection and its application in oral squamous cell carcinomaMultidimensional Systems and Signal Processing10.1007/s11045-017-0488-628:3(1031-1050)Online publication date: 1-Jul-2017
  • (2016)Reinforced random forestProceedings of the Tenth Indian Conference on Computer Vision, Graphics and Image Processing10.1145/3009977.3010003(1-8)Online publication date: 18-Dec-2016
  • (2015)Regenerative Random Forest with Automatic Feature Selection to Detect Mitosis in Histopathological Breast Cancer ImagesMedical Image Computing and Computer-Assisted Intervention -- MICCAI 201510.1007/978-3-319-24571-3_12(94-102)Online publication date: 20-Nov-2015

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