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A hybrid genetic search for multiple sequence alignment

Published: 08 July 2006 Publication History

Abstract

This paper proposes a hybrid genetic algorithm for multiple sequence alignment. The algorithm evolves guide sequences and aligns input sequences based on the guide sequences. It also embeds a local search heuristic to search the problem space effectively. In the experiments for various data sets, the proposed algorithm showed the performance comparable to existing algorithms.

References

[1]
D. Gusfield. Efficient methods for multiple sequence alignment with guaranteed error bounds. Bull. Math. Biol., 55(1):141--154, 1993.
[2]
C. Shyu, L. Sheneman, and J. A. Foster. Multiple sequence alignment with evolutionary computation. Genetic Programming and Evolvable Machines, 5(2):121--144, 2004.

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Published In

cover image ACM Conferences
GECCO '06: Proceedings of the 8th annual conference on Genetic and evolutionary computation
July 2006
2004 pages
ISBN:1595931864
DOI:10.1145/1143997
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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Association for Computing Machinery

New York, NY, United States

Publication History

Published: 08 July 2006

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Author Tags

  1. bioinformatics
  2. genetic algorithms
  3. local search
  4. multiple sequence

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GECCO06
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GECCO06: Genetic and Evolutionary Computation Conference
July 8 - 12, 2006
Washington, Seattle, USA

Acceptance Rates

GECCO '06 Paper Acceptance Rate 205 of 446 submissions, 46%;
Overall Acceptance Rate 1,669 of 4,410 submissions, 38%

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