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Structural tailoring of fucoidan backbones for maximizing their benefits: Enzymatic, chemical, and physical strategies

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A Correction to this article was published on 07 March 2024

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Abstract

Fucoidans are a heterogenous class of sulfated, fucose-rich, and high molecular weight polysaccharides derived mainly from brown seaweeds. They have attracted particular interest in different scientific and industrial fields. Nevertheless, their applications are affected by various chemical properties, including molecular weight, sulfation pattern, and degree of sulphation. For instance, most of the reported bioactivities (e.g., immunomodulatory and cytotoxic activities) have been enhanced with more sulfated and low molecular weight fractions, in contrast to the anticoagulant effect. Additionally, high molecular weight fucoidans are unsuitable for nanomedicine formulation, oral absorption, and distribution to various body organs. Hence, different strategies have been developed as a subsequent stage of processing to modify the native fucoidans in order to produce more bioactive and efficiently formulated products. The current article highlights the various enzymatic (e.g., fucoidanase and fucoidan sulfatase), chemical, and other strategies used for structural modifications of native fucoidans accompanied by varied bioactivities. Interestingly, the enzymatic method has proved to be more specific and selective retaining the native sulfated chemical backbone efficiently. Hence, this review may help in tayloring new fucoidan derivatives for targeted homogenous production and maximized applications of fucoidans in the medical and pharmaceutical fields.

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Data Availability

The data is available from the corresponding author on request.

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Authors and Affiliations

  1. Institute of Bioprocess Engineering, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Gottlieb-Daimler-Straße 49, 67663, Kaiserslautern, Germany

    Ahmed Zayed & Roland Ulber

  2. Department of Pharmacognosy, College of Pharmacy, Tanta University, El-Guish Street (Medical Campus), Tanta, 31527, Egypt

    Ahmed Zayed

  3. NhaTrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, 02 Hung Vuong Street, Nhatrang, 650000, Vietnam

    Hang Thi Thuy Cao & Vo Thi Dieu Trang

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  1. Ahmed Zayed
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  2. Hang Thi Thuy Cao
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  4. Roland Ulber
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Conceptualization, A.Z. and R.U.; writing original draft, A.Z., H.C. and V.T.; writing review and editing, A.Z. and R.U.; supervision, A.Z. and R.U.; project administration, A.Z. and R.U.; funding acquisition, R.U. and A.Z. All authors have read and agreed to the published version of the manuscript.

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The original online version of this article was revised: In this article the affiliation 'NhaTrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, 02 Hung Vuong Street, Nhatrang 650000, Vietnam' for Authors Dr. Cao and Dr. Trang was missing.

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Zayed, A., Cao, H.T.T., Trang, V.T.D. et al. Structural tailoring of fucoidan backbones for maximizing their benefits: Enzymatic, chemical, and physical strategies. J Appl Phycol 35, 2445–2462 (2023). https://doi.org/10.1007/s10811-023-03036-6

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