Metabolomics is a novel “omics” branch of science intended for studying a comprehensive set
of low molecular weight substances (metabolites) of various biological objects. Metabolite profiles
represent a molecular phenotype of biological systems and reflect information encoded at the genome
level and realized at the transcriptome and proteome levels. Analysis of human blood metabolic
profile is universal and promising tool for clinical applications because it is a sensitive measure
of both endogenous and exogenous (environmental) factors affected on the patient's organism.
Technical implementation of metabolic profiling of blood and statistic analysis of metabolite profiles
for effective diagnostics and risk assessments of diseases are discussed in this review.
Ellis D.I., Dunn W.B., Griffin J.L., Allwood J.W., Goodacre R. (2007) Pharmacogenomics, 8, 1243-1266. CrossRef Scholar google search
Schauer N., Steinhauser D., Strelkov S., Schomburg D., Allison G., Moritz T., Lundgren K., Roessner-Tunali U., Forbes M.G., Willmitzer L., Fernie A.R., Kopka J. (2005) FEBS Lett., 579, 1332-1337. CrossRef Scholar google search
Begley P., Francis-McIntyre S., Dunn W.B., Broadhurst D.I., Halsall A., Tseng A., Knowles J., Goodacre R., Kell D.B. (2009) Anal. Chem., 81, 7038-7046. CrossRef Scholar google search
Wilson I.D., Nicholson J.K., Castro-Perez J., Granger J.H., Johnson K.A., Smith B.W., Plumb R.S. (2005) J. Proteome Res., 4, 591-598. CrossRef Scholar google search
Jonsson P., Bruce S.J., Moritz T., Trygg J., Sjostrom M., Plumb R., Granger J., Maibaum E., Nicholson J.K.,Holmes E.,Antti H. (2005)Analyst, 130, 701-707. CrossRef Scholar google search
Broeckling C.D., Reddy I.R., Duran A.L., Zhao X., Sumner L.W. (2006) Anal. Chem., 78, 4334-4341. CrossRef Scholar google search
Baran R., Kochi H., Saito N., Suematsu M., Soga T., Nishioka T., Robert M., Tomita M. (2006) BMC Bioinformatics, 7, 530. CrossRef Scholar google search
Denkert C., Budczies J., Weichert W., Wohlgemuth G., Scholz M., Kind T., Niesporek S., Noske A., Buckendahl A., Dietel M., Fiehn O. (2008) Mol. Cancer., 7, 72. Scholar google search
Wishart D.S., Tzur D., Knox C., Eisner R., Guo A.C., Young N., Cheng D., Jewell K., Arndt D., Sawhney S., Fung C., Nikolai L., Lewis M., Coutouly M.A., Forsythe I., Tang P., Shrivastava S., Jeroncic K., Stothard P., Amegbey G., Block D., Hau D.D., Wagner J., Miniaci J., Clements M., Gebremedhin M., Guo N., Zhang Y., Duggan G.E., Macinnis G.D., Weljie A.M., Dowlatabadi R., Bamforth F., Clive D., Greiner R., Li L., Marrie T., Sykes B.D., Vogel H.J., Querengesser L. (2007) Nucleic Acids Res., 35 (Database issue), D521-526. CrossRef Scholar google search
Wishart D.S., Knox C., Guo A.C., Eisner R., Young N., Gautam B., Hau D.D., Psychogios N., Dong E., Bouatra S., Mandal R., Sinelnikov I., Xia J., Jia L., Cruz J.A., Lim E., Sobsey C.A., Shrivastava S., Huang P., Liu P., Fang L., Peng J., Fradette R., Cheng D., Tzur D., Clements M., Lewis A., De Souza A., Zuniga A., Dawe M., Xiong Y., Clive D., Greiner R., Nazyrova A., Shaykhutdinov R., Li L., Vogel H.J., Forsythe I. (2009) Nucleic Acids Res., 37 (Database issue), D603-610. CrossRef Scholar google search
Sabatine M.S., Liu E., Morrow D.A., Heller E., McCarroll R., Wiegand R., Berriz G.F., Roth F.P., Gerszten R.E. (2005) Circulation, 112, 3868-3875. CrossRef Scholar google search
Wang T.J., Larson M.G., Vasan R.S., Cheng S., Rhee E.P., McCabe E., Lewis G.D., Fox C.S., Jacques P.F., Fernandez C., O'Donnell C.J., Carr S.A., Mootha V.K., Florez J.C., Souza A., Melander O., Clish C.B., Gerszten R.E. (2011) Nat. Med., 17, 448-453. Scholar google search
Odunsi K., Wollman R.M., Ambrosone C.B., Hutson A., McCann S.E., Tammela J., Geisler J.P., Miller G., Sellers T., Cliby W., Qian F., Keitz B., Intengan M., Lele S., Alderfer J.L. (2005) Int. J. Cancer, 113, 782-788. CrossRef Scholar google search
Sun J., Shannon M., Ando Y., Schnackenberg L.K., Khan N.A., Portilla D., Beger R.D. (2012) J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 893-894, 107-113. CrossRef Scholar google search
Gutiu I.A., Andries A., Radulescu F., Georgescu A-M., Cioaca D. (2010) Rom. J. Intern. Med., 48, 187-191. Scholar google search
Kaddurah-Daouk R., Kristal B.S., Weinshilboum R.M. (2008) Annu. Rev. Pharmacol. Toxicol., 48, 653-683. CrossRef Scholar google search