This paper deals with the small-scale fading distribution for UWB channels in the absence and presence of human bodies in indoor line-of-sight (LOS) environments and performance analysis of UWB systems considering the small-scale fading distribution. To obtain small-scale fading statistics, the channel measurements are performed in five representative environments that have different structure and size while locating the receiver (Rx) antenna on 49 (7×7 grid) local points with a fixed transmitter (Tx) antenna in each environment. The measured channel data are processed by a vector network analyzer and the target frequency bands range from 3 to 4.6GHz. From the measured data, we find the best fitted channel model among several typical theoretical distribution models such as Lognormal, Nakagami, and Weibull distributions, showing good agreement with the empirical channel data. We analyze the amplitude variation of the small-scale fading distribution in the absence and presence of human bodies. The results show that the small-scale fading statistics are best described by Weibull distribution and the two parameters of the distribution that determine the shape and the scale of the distribution depend on whether or not human bodies exist. We modeled and analyzed two parameters at different excess delays for all environments. Based on the measured small-scale fading distribution, this paper deals with the performance of UWB system using Rake receivers and also compares the performance with the existing channel model. The results suggest that the small-scale fading distribution in the absence and the presence of human bodies in indoor LOS environments should be considered when assessing the performance of UWB systems.