In this work we use the concept of a ‘n’-valued refined neutrosophic soft sets and its properties to solve decision making problems, Also a similarity measure between two ‘n’-valued refined neutrosophic soft sets are proposed. A medical diagnosis (MD) method is established for ‘n’-valued refined neutrosophic soft set setting using similarity measures. Lastly a numerical example is given to demonstrate the possible application of similarity measures in medical diagnosis (MD).