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Licensed Unlicensed Requires Authentication Published by De Gruyter August 19, 2005

Detection of brain injury by fatty acid-binding proteins

  • Maurice M. A. L. Pelsers and Jan F. C. Glatz

Abstract

The rapid detection of brain injury (neuronal damage in general) is an important parameter in the management of cerebrovascular accidents, especially in hemorrhagic and/or ischemic events. Two types of 15-kDa cytoplasmic fatty acid-binding proteins (FABPs), brain-type FABP and heart-type FABP, have recently been postulated as novel markers for brain injury detection. Here we review the possible roles of these FABPs as rapid diagnostic markers for the detection of brain injury due to cerebrovascular accident, trauma or neurodegenerative diseases. The occurrence of brain- and heart-type FABPs in segments of the human brain is also described. Although only limited amounts of data are available, brain- and heart-type FABPs show higher sensitivities and specificities than protein S100 and neuron specific enolase in the rapid detection of brain injury in stroke, trauma and neurodegenerative diseases.


Corresponding author: M.M.A.L. Pelsers PhD, Maastricht University, Department of Molecular Genetics, P.O. Box 616, 6200 MD Maastricht, The Netherlands Phone: +31-43-3882102, Fax: +31-43-3884574,

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Received: 2005-4-19
Accepted: 2005-6-7
Published Online: 2005-8-19
Published in Print: 2005-8-1

©2005 by Walter de Gruyter Berlin New York

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