ZEB1

ZEB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2E19
Dynodwyr
Cyfenwau	ZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
Dynodwyr allanol	OMIM: 189909 HomoloGene: 31779 GeneCards: ZEB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0001106 transcription corepressor activity • GO:0001105 transcription coactivator activity • zinc ion binding • transcription factor binding • chromatin binding • metal ion binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • E-box binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • transcription regulator complex • cnewyllyn cell • nucleoplasm • cytosol Prosesau biolegol • pattern specification process • embryonic skeletal system morphogenesis • regulation of smooth muscle cell differentiation • animal organ development • cell differentiation • semicircular canal morphogenesis • GO:0009373 regulation of transcription, DNA-templated • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • transcription, DNA-templated • nervous system development • regulation of transforming growth factor beta receptor signaling pathway • regulation of T cell differentiation in thymus • central nervous system development • cartilage development • regulation of mesenchymal cell proliferation • embryonic camera-type eye morphogenesis • cochlea morphogenesis • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • embryonic morphogenesis • cellular response to amino acid stimulus • cell population proliferation • negative regulation of epithelial cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated • positive regulation of neuron differentiation • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of endothelial cell differentiation • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	6935	n/a
Ensembl	ENSG00000148516	n/a
UniProt	P37275	n/a
RefSeq (mRNA)	NM_001128128 NM_001174093 NM_001174094 NM_001174095 NM_001174096 NM_030751 NM_001323638 NM_001323641 NM_001323642 NM_001323643 NM_001323644 NM_001323645 NM_001323646 NM_001323647 NM_001323648 NM_001323649 NM_001323650 NM_001323651 NM_001323652 NM_001323653 NM_001323654 NM_001323655 NM_001323656 NM_001323657 NM_001323658 NM_001323659 NM_001323660 NM_001323661 NM_001323662 NM_001323663 NM_001323664 NM_001323665 NM_001323666 NM_001323671 NM_001323672 NM_001323673 NM_001323674 NM_001323675 NM_001323676 NM_001323677 NM_001323678	n/a
RefSeq (protein)	NP_001121600 NP_001167564 NP_001167565 NP_001167566 NP_001167567 NP_001310567 NP_001310570 NP_001310571 NP_001310572 NP_001310573 NP_001310574 NP_001310575 NP_001310576 NP_001310577 NP_001310578 NP_001310579 NP_001310580 NP_001310581 NP_001310582 NP_001310583 NP_001310584 NP_001310585 NP_001310586 NP_001310587 NP_001310588 NP_001310589 NP_001310590 NP_001310591 NP_001310592 NP_001310593 NP_001310594 NP_001310595 NP_001310600 NP_001310601 NP_001310602 NP_001310603 NP_001310604 NP_001310605 NP_001310606 NP_001310607 NP_110378	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ZEB1 yw ZEB1 a elwir hefyd yn Zinc finger E-box-binding homeobox 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10p11.22.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ZEB1.

• "Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma. ". PLoS One. 2017. PMID 28945795.
• "Agenesis of the corpus callosum, developmental delay, autism spectrum disorder, facial dysmorphism, and posterior polymorphous corneal dystrophy associated with ZEB1 gene deletion. ". Am J Med Genet A. 2017. PMID 28742278.
• "ZEB1 is neither sufficient nor required for epithelial-mesenchymal transition in LS174T colorectal cancer cells. ". Biochem Biophys Res Commun. 2017. PMID 27923654.
• "Upregulation of LncRNA-HIT promotes migration and invasion of non-small cell lung cancer cells by association with ZEB1. ". Cancer Med. 2016. PMID 27790864.
• "Dephosphorylation of the Retinoblastoma protein (Rb) inhibits cancer cell EMT via Zeb.". Cancer Biol Ther. 2016. PMID 27645778.