PPARG

PPARG
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FM6, 1FM9, 1I7I, 1K74, 1KNU, 1NYX, 1PRG, 1RDT, 1WM0, 1ZEO, 1ZGY, 2ATH, 2F4B, 2FVJ, 2G0G, 2G0H, 2GTK, 2HFP, 2HWQ, 2HWR, 2I4J, 2I4P, 2I4Z, 2OM9, 2P4Y, 2POB, 2PRG, 2Q59, 2Q5P, 2Q5S, 2Q61, 2Q6R, 2Q6S, 2Q8S, 2QMV, 2VSR, 2VST, 2VV0, 2VV1, 2VV2, 2VV3, 2VV4, 2XKW, 2YFE, 2ZK0, 2ZK1, 2ZK2, 2ZK3, 2ZK4, 2ZK5, 2ZK6, 2ZNO, 2ZVT, 3ADS, 3ADT, 3ADU, 3ADV, 3ADW, 3ADX, 3AN3, 3AN4, 3B0Q, 3B0R, 3B1M, 3B3K, 3BC5, 3CDP, 3CDS, 3CS8, 3CWD, 3D6D, 3DZU, 3DZY, 3E00, 3ET0, 3ET3, 3FEJ, 3FUR, 3G9E, 3GBK, 3H0A, 3HO0, 3HOD, 3IA6, 3K8S, 3KMG, 3LMP, 3NOA, 3OSI, 3OSW, 3PBA, 3PO9, 3PRG, 3QT0, 3R5N, 3R8A, 3R8I, 3S9S, 3SZ1, 3T03, 3TY0, 3U9Q, 3V9T, 3V9V, 3V9Y, 3VJH, 3VJI, 3VN2, 3VSO, 3VSP, 3WJ4, 3WJ5, 3WMH, 3X1H, 3X1I, 4A4V, 4A4W, 4CI5, 4E4K, 4E4Q, 4EM9, 4EMA, 4F9M, 4FGY, 4HEE, 4JAZ, 4JL4, 4L96, 4L98, 4O8F, 4OJ4, 4PRG, 4PVU, 4PWL, 4R2U, 4R6S, 4XLD, 4R06, 4Y29, 4XTA, 4XUM, 4YT1, 4XUH, 5F9B, 5AZV
Dynodwyr
Cyfenwau	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma, PPARG5
Dynodwyr allanol	OMIM: 601487 HomoloGene: 7899 GeneCards: PPARG
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • alpha-actinin binding • chromatin binding • prostaglandin receptor activity • core promoter sequence-specific DNA binding • enzyme binding • protein phosphatase binding • metal ion binding • arachidonic acid binding • nuclear receptor coactivator activity • steroid hormone receptor activity • sequence-specific DNA binding • identical protein binding • GO:0038050, GO:0004886, GO:0038051 nuclear receptor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • double-stranded DNA binding • protein C-terminus binding • zinc ion binding • peptide binding • protein self-association • retinoid X receptor binding • protein heterodimerization activity • DNA binding domain binding • LBD domain binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription factor binding • estrogen receptor binding • E-box binding • GO:0000975 transcription cis-regulatory region binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • fatty acid binding • lipid binding • signaling receptor activity Cydrannau o'r gell • cytosol • RNA polymerase II transcription regulator complex • perinuclear region of cytoplasm • cytoplasm • cnewyllyn cell • intracellular membrane-bounded organelle • nucleoplasm • GO:0009327 protein-containing complex Prosesau biolegol • negative regulation of cell population proliferation • epithelial cell differentiation • negative regulation of smooth muscle cell proliferation • positive regulation of oligodendrocyte differentiation • transcription, DNA-templated • activation of cysteine-type endopeptidase activity involved in apoptotic process • response to lipid • placenta development • cellular response to vitamin E • negative regulation of interferon-gamma-mediated signaling pathway • negative regulation of sequestering of triglyceride • regulation of fat cell differentiation • cellular response to retinoic acid • glucose homeostasis • negative regulation of collagen biosynthetic process • cellular response to hyperoxia • response to estrogen • regulation of cholesterol transporter activity • regulation of circadian rhythm • negative regulation of telomerase activity • GO:0072468 signal transduction • cellular response to insulin stimulus • monocyte differentiation • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • regulation of blood pressure • positive regulation of apoptotic process • positive regulation of fat cell differentiation • negative regulation of cholesterol storage • GO:0009373 regulation of transcription, DNA-templated • negative regulation of cell growth • GO:0045996 negative regulation of transcription, DNA-templated • cellular response to prostaglandin stimulus • animal organ regeneration • positive regulation of DNA-binding transcription factor activity • lipoprotein transport • response to metformin • heart development • response to cold • negative regulation of acute inflammatory response • fatty acid oxidation • lipid homeostasis • transcription initiation from RNA polymerase II promoter • response to vitamin A • innate immune response • response to retinoic acid • cell maturation • cell fate commitment • peroxisome proliferator activated receptor signaling pathway • proses rythmig • response to mechanical stimulus • long-chain fatty acid transport • lipid metabolism • response to caffeine • positive regulation of fatty acid oxidation • response to immobilization stress • positive regulation of phagocytosis, engulfment • negative regulation of pancreatic stellate cell proliferation • response to starvation • GO:1904578 response to organic cyclic compound • regulation of lipid metabolic process • steroid hormone mediated signaling pathway • response to organic substance • response to nutrient • cellular response to prostaglandin E stimulus • GO:1901227 negative regulation of transcription by RNA polymerase II • white fat cell differentiation • negative regulation of macrophage derived foam cell differentiation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • G protein-coupled receptor signaling pathway • macrophage derived foam cell differentiation • positive regulation of DNA binding • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • negative regulation of angiogenesis • negative regulation of blood vessel endothelial cell migration • pri-miRNA transcription by RNA polymerase II • GO:1905617 negative regulation of gene silencing by miRNA • cellular response to low-density lipoprotein particle stimulus • positive regulation of vascular associated smooth muscle cell apoptotic process • negative regulation of vascular endothelial cell proliferation • negative regulation of vascular associated smooth muscle cell proliferation • fatty acid metabolic process • multicellular organism development • hormone-mediated signaling pathway • cell differentiation • intracellular receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5468	n/a
Ensembl	ENSG00000132170	n/a
UniProt	P37231	n/a
RefSeq (mRNA)	NM_005037 NM_015869 NM_138711 NM_138712 NM_001330615 NM_001354666 NM_001354667 NM_001354668 NM_001354669 NM_001354670 NM_001374261 NM_001374262 NM_001374263 NM_001374264 NM_001374265 NM_001374266	n/a
RefSeq (protein)	NP_001317544 NP_005028 NP_056953 NP_619725 NP_619726 NP_001341595 NP_001341596 NP_001341597 NP_001341598 NP_001341599 NP_001361190 NP_001361191 NP_001361192 NP_001361193 NP_001361194 NP_001361195	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PPARG yw PPARG a elwir hefyd yn Peroxisome proliferator-activated receptor gamma a Peroxisome proliferator activated receptor gamma (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p25.2.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PPARG.

• "Pharmacological PPARγ modulation regulates sebogenesis and inflammation in SZ95 human sebocytes. ". Biochem Pharmacol. 2017. PMID 28461124.
• "Peroxisome proliferator-activated receptor gamma (PPARγ) is central to the initiation and propagation of human angiomyolipoma, suggesting its potential as a therapeutic target". EMBO Mol Med. 2017. PMID 28275008.
• "Genomic Activation of PPARGReveals a Candidate Therapeutic Axis in Bladder Cancer. ". Cancer Res. 2017. PMID 28923856.
• "PPARγ2 C1431T Polymorphism Interacts with the Antiobesogenic Effects of Kochujang, a Korean Fermented, Soybean-Based Red Pepper Paste, in Overweight/Obese Subjects: A 12-Week, Double-Blind Randomized Clinical Trial. ". J Med Food. 2017. PMID 28622115.
• "Structural review of PPARγ in complex with ligands: Cartesian- and dihedral angle principal component analyses of X-ray crystallographic data.". Proteins. 2017. PMID 28543443.