PLA2G4A

PLA2G4A
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BCI, 1CJY, 1RLW
Dynodwyr
Cyfenwau	PLA2G4A, PLA2G4, cPLA2-alpha, cPLA2, phospholipase A2 group IVA, GURDP
Dynodwyr allanol	OMIM: 600522 HomoloGene: 32059 GeneCards: PLA2G4A
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • calcium ion binding • hydrolase activity • calcium-dependent phospholipid binding • phospholipase activity • phospholipase A2 activity • phospholipase A1 activity • lysophospholipase activity • calcium-dependent phospholipase A2 activity Cydrannau o'r gell • Golgi apparatus • Reticwlwm endoplasmig • endoplasmic reticulum membrane • GO:0016023 cytoplasmic vesicle • mitochondrial inner membrane • cytoplasm • lipid droplet • cytosol • cnewyllyn cell Prosesau biolegol • phospholipid metabolic process • phosphatidylinositol acyl-chain remodeling • platelet activating factor biosynthetic process • arachidonic acid secretion • icosanoid metabolic process • lipid metabolism • phosphatidylserine acyl-chain remodeling • phospholipid catabolic process • phosphatidylglycerol acyl-chain remodeling • GO:1904577 cellular response to antibiotic • lipid catabolic process • phosphatidic acid biosynthetic process • phosphatidylcholine acyl-chain remodeling • metabolaeth • regulation of cell population proliferation • phosphatidylethanolamine acyl-chain remodeling • cardiolipin acyl-chain remodeling • icosanoid biosynthetic process • arachidonic acid metabolic process • glycerophospholipid catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5321	n/a
Ensembl	ENSG00000116711	n/a
UniProt	P47712	n/a
RefSeq (mRNA)	NM_001311193 NM_024420	n/a
RefSeq (protein)	NP_001298122 NP_077734	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn PLA2G4A yw PLA2G4A a elwir hefyd yn Phospholipase A2 group IVA (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q31.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn PLA2G4A.

• cPLA2
• PLA2G4
• cPLA2-alpha

• "Targeting of cytosolic phospholipase A2α impedes cell cycle re-entry of quiescent prostate cancer cells. ". Oncotarget. 2015. PMID 26416244.
• "Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation. ". FASEB J. 2015. PMID 26183771.
• "Cytosolic phospholipase A2α increases proliferation and de-differentiation of human renal tubular epithelial cells. ". Prostaglandins Other Lipid Mediat. 2016. PMID 27554058.
• "Cytosolic phospholipase A2 (cPLA2) IVA as a potential signature molecule in cigarette smoke condensate induced pathologies in alveolar epithelial lineages. ". Lipids Health Dis. 2016. PMID 27528014.
• "Mapping the Human Platelet Lipidome Reveals Cytosolic Phospholipase A2 as a Regulator of Mitochondrial Bioenergetics during Activation.". Cell Metab. 2016. PMID 27133131.