SAE1

SAE1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Y8Q, 1Y8R, 3KYC, 3KYD
Dynodwyr
Cyfenwau	SAE1, AOS1, HSPC140, SUA1, UBLE1A, SUMO1 activating enzyme subunit 1
Dynodwyr allanol	OMIM: 613294 HomoloGene: 4019 GeneCards: SAE1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ubiquitin activating enzyme activity • SUMO activating enzyme activity • GO:0010577 enzyme activator activity • ligase activity • protein C-terminus binding • ubiquitin-like modifier activating enzyme activity • GO:0001948, GO:0016582 protein binding • ATP-dependent protein binding • small protein activating enzyme binding • protein heterodimerization activity Cydrannau o'r gell • SUMO activating enzyme complex • cnewyllyn cell • nucleoplasm • cytoplasm Prosesau biolegol • protein sumoylation • protein ubiquitination • positive regulation of protein targeting to mitochondrion • GO:0048554 positive regulation of catalytic activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10055	n/a
Ensembl	ENSG00000142230	n/a
UniProt	Q9UBE0	n/a
RefSeq (mRNA)	NM_001145713 NM_001145714 NM_005500	n/a
RefSeq (protein)	NP_001139185 NP_001139186 NP_005491	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SAE1 yw SAE1 a elwir hefyd yn SUMO-activating enzyme subunit 1 a SUMO1 activating enzyme subunit 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.32.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SAE1.

• "Small ubiquitin-like modifier (SUMO) modification of E1 Cys domain inhibits E1 Cys domain enzymatic activity. ". J Biol Chem. 2012. PMID 22403398.
• "Importin α/β mediates nuclear import of individual SUMO E1 subunits and of the holo-enzyme. ". Mol Biol Cell. 2011. PMID 21209321.
• "[Lentivirus-mediated siRNA targeting sae1 induces cell cycle arrest and apop- tosis in colon cancer cell RKO]. ". Mol Biol (Mosk). 2014. PMID 25842831.
• "Anti-SAE antibodies in autoimmune myositis: identification by unlabelled protein immunoprecipitation in an Italian patient cohort. ". J Immunol Methods. 2012. PMID 22884621.
• "Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.". Chem Biol. 2009. PMID 19246003.