IL2RA

IL2RA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1Z92, 2B5I, 2ERJ, 3IU3, 3NFP
Dynodwyr
Cyfenwau	IL2RA, CD25, IDDM10, IL2R, TCGFR, p55, IMD41, interleukin 2 receptor subunit alpha
Dynodwyr allanol	OMIM: 147730 HomoloGene: 360 GeneCards: IL2RA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • interleukin-2 receptor activity • interleukin-2 binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • integral component of membrane • bilen • Cellbilen • cell surface • external side of plasma membrane • intracellular anatomical structure • interleukin-2 receptor complex Prosesau biolegol • Notch signaling pathway • positive regulation of T cell differentiation • regulation of T cell tolerance induction • inflammatory response to antigenic stimulus • negative regulation of defense response to virus • immune system process • activation-induced cell death of T cells • negative regulation of lymphocyte proliferation • MAPK cascade • T cell homeostasis • regulation of T cell homeostatic proliferation • cell surface receptor signaling pathway • negative regulation of T cell proliferation • negative regulation of immune response • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of T cell proliferation • cell population proliferation • inflammatory response • negative regulation of inflammatory response • positive regulation of activated T cell proliferation • GO:0097285 apoptotic process • regulation of regulatory T cell differentiation • cytokine-mediated signaling pathway • interleukin-2-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3559	n/a
Ensembl	ENSG00000134460	n/a
UniProt	P01589	n/a
RefSeq (mRNA)	NM_000417 NM_001308242 NM_001308243	n/a
RefSeq (protein)	NP_000408 NP_001295171 NP_001295172	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IL2RA yw IL2RA a elwir hefyd yn Interleukin-2 receptor subunit alpha ac Interleukin 2 receptor subunit alpha (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10p15.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IL2RA.

• "Expression of CD25 on leukemic stem cells in BCR-ABL1+ CML: Potential diagnostic value and functional implications. ". Exp Hematol. 2017. PMID 28457753.
• "CD25 Expression in B Lymphoblastic Leukemia/Lymphoma Predicts t(9;22)(q34;q11)/Philadelphia Chromosome Translocation (Ph) and Is Associated With Residual Disease in Ph-Negative Patients. ". Am J Clin Pathol. 2016. PMID 28430957.
• "CD25 as an adverse prognostic factor in elderly patients with acute myeloid leukemia. ". Hematology. 2017. PMID 28097942.
• "The serum concentration of soluble interleukin-2 receptor in patients with Kawasaki disease. ". Ann Clin Biochem. 2017. PMID 28081636.
• "Interleukin-2 receptor-α proximal promoter hypomethylation is associated with multiple sclerosis.". Genes Immun. 2017. PMID 28077880.