Papers by Prof. Dr. Salvatore Sauro
Gaceta Dental Industria Y Profesiones, May 1, 2014
ABSTRACT Innovative therapeutic restorative materials should be developed to remineralise and imp... more ABSTRACT Innovative therapeutic restorative materials should be developed to remineralise and improve the longevity of dental restorations performed during minimally invasive dentistry. The aim of this study was to evaluate the ability of an innovative light-curable resin-based dental material containing bioactive calcium-phosphosilicates micro-filler to induce apatite deposition in demineralised dentine. The apatite formation was assessed by ATR-FTIR, XRD, and SEM analysis after immersion in artificial saliva (AS). Water sorption/solubility, alkalinising activity (pH) and biocompatibility, were also evaluated. An experimental calcium-zinc-phosphate silicate-base micro-filler was modified with acid 4-oxoheptanodioico and incorporated in a resin-based material. A control filler-free resin blend was also formulated. Disc specimens were polymerised and submitted to pH/alkalinising activity and water sorption/ solubility analyses. The bioactivity (apatite precipitation) induced by the tested materials were evaluated through ATR/ FTIR vibrational analysis, SEM and XRD analyses subsequent to AS storage of the materials specimens and demineralised dentine maintained in close contact. The experimental resin containing the bioactive micro-filler was able to induce apatite precipitation subsequent to prolonged AS storage, which also induced water sorption and solubility mass changes (P < 0.05). The experimental bioactive resin showed higher biocompatibility compared to the control resin. The use of such light-curable bioactive material in restorative dentistry might represent a potentially therapeutic approach to increase the longevity of the restorations performed in minimally invasive dentistry via apatite deposition within the mineral-depleted tissues.
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International Journal of Adhesion and Adhesives, 2016
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Gaceta Dental Industria Y Profesiones, 2014
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Dental Materials, 2016
This study aimed to assess the degree of conversion, microhardness, solvent degradation, contact ... more This study aimed to assess the degree of conversion, microhardness, solvent degradation, contact angle, surface free energy and bioactivity (e.g., mineral precipitation) of experimental resin-based materials containing, pure or triclosan-encapsulated, aluminosilicate-(halloysite) nanotubes. An experimental resin blend was prepared using bis-GMA/TEGDMA, 75/25wt% (control). Halloysite nanotubes (HNT) doped with or without triclosan (TCN) were first analyzed using transmission electron microscopy (TEM). HNT or HNT/TCN fillers were incorporated into the resin blend at different concentrations (5, 10, and 20wt%). Seven experimental resins were created and the degree of conversion, microhardness, solvent degradation and contact angle were assessed. Bioactive mineral precipitation induced by the experimental resins was evaluated through Raman spectroscopy and SEM-EDX. TEM showed a clear presence of TCN particles inside the tubular lumen and along the outer surfaces of the halloysite nanotubes. The degree of conversion, surface free energy, microhardness, and mineral deposition of polymers increased with higher amount of HNTs. Conversely, the higher the amount (20wt%) of TCN-loaded HNTs the lower the microhardness of the experimental resins. The incorporation of pure or TCN-loaded aluminosilicate-(halloysite) nanotubes into resin-based materials increase the bioactivity of such experimental restorative materials and promotes mineral deposition. Therefore, innovative resin-based materials containing functional halloysite-nanotube fillers may represent a valuable alternative for therapeutic minimally invasive treatments.
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Caries research, Jan 14, 2016
The present investigation evaluated the ability of an experimental di-calcium phosphate (DCP) des... more The present investigation evaluated the ability of an experimental di-calcium phosphate (DCP) desensitising agent used alone or combined with phytosphingosine (PHS) to occlude dentine tubules and resist a citric acid (CA) or artificial saliva (AS) challenge. Three groups of human dentine specimens (DS) were treated with the following: (1) PHS alone, (2) DCP or (3) a combination of PHS and DCP. Dentine hydraulic conductance of DS was evaluated using a digital flow sensor at 6.9 kPa. The average fluid volume for each of the treated DS was used to calculate the total dentine permeability reduction (%P) prior to and following CA immersion for 1 min or AS immersion for 4 weeks. The treated DS were subjected to both scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy analysis. Statistically significant differences (%P) were identified between the groups by ANOVA and Fisher's multiple comparison test (p < 0.05), respectively. Interestingly, both PHS...
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Clinical Oral Investigations, 2015
The aim of this study is to evaluate the distribution of the filler size along with the zeta pote... more The aim of this study is to evaluate the distribution of the filler size along with the zeta potential, and the integrity of silane-bonded filler surface in different types of restorative dental composites as a function of the material age condition. Filtek P60 (hybrid composite), Filtek Z250 (small-particle filled composite), Filtek Z350XT (nanofilled composite), and Filtek Silorane (silorane composite) (3M ESPE) were tested at different stage condition (i.e., fresh/new, aged, and expired). Composites were submitted to an accelerated aging protocol (Arrhenius model). Specimens were obtained by first diluting each composite specimen in ethanol and then dispersed in potassium chloride solution (0.001 mol%). Composite fillers were characterized for their zeta potential, mean particle size, size distribution, via poly-dispersion dynamic light scattering. The integrity of the silane-bonded surface of the fillers was characterized by FTIR. The material age influenced significantly the outcomes; Zeta potential, filler characteristics, and silane integrity varied both after aging and expiration. Silorane presented the broadest filler distribution and lowest zeta potential. Nanofilled and silorane composites exhibited decreased peak intensities in the FTIR analysis, indicating a deficiency of the silane integrity after aging or expiry time. Regardless to the material condition, the hybrid and the small-particle-filled composites were more stable overtime as no significant alteration in filler size distribution, diameter, and zeta potential occurred. A deficiency in the silane integrity in the nanofilled and silorane composites seems to be affected by the material stage condition. The materials conditions tested in this study influenced the filler size distribution, the zeta potential, and integrity of the silane adsorbed on fillers in the nanofilled and silorane composites. Thus, this may result in a decrease of the clinical performance of aforementioned composites, in particular, if these are used after inappropriate storage conditions.
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Brain Injury, 2016
The aim of this study was to investigate the reparative potential of a polymeric scaffold designe... more The aim of this study was to investigate the reparative potential of a polymeric scaffold designed for brain tissue repair in combination with lipoic acid. Histological, cytological and structural analysis of a combined treatment after a brain cryo-injury model in rats. Adult Wistar rats were subjected to cryogenic brain injury. A channelled-porous scaffold of ethyl acrylate and hydroxyethylacrylate, p(EA-co-HEA) was grafted into cerebral penumbra alone or combined with intraperitoneal LA administration. Histological and cytological evaluation was performed after 15 and 60 days and structural magnetic resonance (MRI) assessment was performed at 2 and 6 months after the surgery. The scaffold was suitable for the establishment of different cellular types. The results obtained suggest that this strategy promotes blood vessels formation, decreased microglial response and neuron migration, particularly when LA was administrated. These evidences demonstrated that the combination of a channelled polymer scaffold with LA administration may represent a potential treatment for neural tissue repair after brain injury.
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Investigadores de odontología de la CEU-UCH han identificado un ácido que mejora la resistencia a... more Investigadores de odontología de la CEU-UCH han identificado un ácido que mejora la resistencia a la degradación de la interfase del adhesivo con la dentina, manteniendo la fuerza de adhesión y con ello la resistencia y durabilidad de los empastes directos, según han informado este martes fuentes de esta institución académica en un comunicado.
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Objectives: The study aimed at determining the relative ability of various air-polishing prophyla... more Objectives: The study aimed at determining the relative ability of various air-polishing prophylactic powders to remineralise and protect enamel against acid challenges. Methods: Cores of enamel were removed from extracted human teeth, lightly ground and polished to provide a flat enamel surface. The enamel was air-polished using different powders formulated on the use of a Calcium/Sodium Phosphosilicate (BAG) or Dicalcium Phosphate Dihydrate (DPD) at air pressure of 5 bar (500 MPa) and a distance of 10 mm. A Na-bicarbonate powder (BIC) was also used as control treatment. The specimens were first immersed in artificial saliva (AS) for 24h at 37°C. Subsequently, the specimens were immersed in 0.1M citric acid [pH: 3.4] using a 3-time-cycle; under continuous agitation (30s); (h: 8:00 – 12:00 – 17:00) and stored in AS at 37°C during the intervals. The complete experimental design was repeated for 3 days. Knoop hardness (KHN), scanning electron microscopy (SEM) and confocal laser micros...
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gen-apr 2014; 10(1) © ariesdue 1 parole chiave air-polishing; enfisema facciale; perio-polishing;... more gen-apr 2014; 10(1) © ariesdue 1 parole chiave air-polishing; enfisema facciale; perio-polishing; polveri dentali abrasive. riassunto Scopo lo scopo di questo lavoro consisteva in una revisione della letteratura scientifica internazionale sull'uso di dispositivi a getto d'aria/acqua (air-polishing) nei trattamenti di profilassi e lucida-tura dentale, nonché nei trattamenti non chirurgici parodontali (perio-polishing). la relazione tra enfisemi facciali e l'uso di tali dispositivi di air-polishing è stata anche uno degli obbiettivi prin-cipali del presente studio. Materiali e metodi Numerosi articoli scientifici pubblicati nel periodo compreso tra il 1945 e il 2012 sono stati selezionati dai principali database medici come Medline e Science Direct. Risultati l'utilizzo di dispositivi a getto d'aria/acqua per i tratta-menti di air-polishng e perio-polishing parodontali possono esse-re considerati un approccio clinico sicuro, vista la scarsa evidenza scientifica sui...
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Dental Materials, 2014
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Dental Materials, 2015
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Cement and Concrete Research, 2012
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Med Oral Patol Oral Cir Bucal, 2011
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Journal of Materials Science Materials in Medicine, Apr 1, 2012
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Papers by Prof. Dr. Salvatore Sauro