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CERN-MEDICIS: A Unique Facility for the Production of Non-Conventional Radionuclides for the Medical Research
/ Duchemin, Charlotte (CERN) ; Barbero-Soto, Esther (CERN) ; Bernardes, Ana (CERN) ; Catherall, Richard (CERN) ; Chevallay, Eric (CERN) ; Cocolios, Thomas (Leuven U.) ; Dorsival, Alexandre (CERN) ; Fedosseev, Valentin (CERN) ; Fernier, Pascal (CERN) ; Gilardoni, Simone (CERN) et al.
The MEDICIS facility is a unique facility located at CERN dedicated to the production of non-conventional radionuclides for research and development in imaging, diagnostics and radiation therapy. It exploits in a Class A work sector, a dedicated isotope separator beam line, a target irradiation station at the 1.4 GeV Proton Synchroton Booster (PSB) and receives activated targets from external institutes during CERN Long Shut-Downs. [...]
CERN-ACC-2021-010.-
2021 - 5 p.
- Published in : JACoW IPAC 2020 (2020) THVIR13
Fulltext: PDF;
In : 11th International Particle Accelerator Conference, Caen, France, 10 - 15 May 2020, pp.THVIR13
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CERN-MEDICIS: A Review Since Commissioning in 2017
/ MEDICIS Collaboration
The CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientific program of this unique installation and evaluate the needs of the community to improve the research in imaging, diagnostics, radiation therapy and personalized medicine. [...]
2021 - 11 p.
- Published in : Frontiers in Medicine 8 (2021) 693682
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Efficient Production of High Specific Activity Thulium-167 at Paul Scherrer Institute and CERN-MEDICIS
/ Heinke, Reinhard (CERN ; Leuven U.) ; Chevallay, Eric (CERN) ; Chrysalidis, Katerina (CERN) ; Cocolios, Thomas E (Leuven U.) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Fedosseev, Valentin N (CERN) ; Hurier, Sophie (Leuven U. ; SCK-CEN, Mol) ; Lambert, Laura (CERN) ; Leenders, Benji (Leuven U. ; SCK-CEN, Mol ; Gent U.) ; Marsh, Bruce A (CERN) et al.
Thulium-167 is a promising radionuclide for nuclear medicine applications with potential use for both diagnosis and therapy (“theragnostics”) in disseminated tumor cells and small metastases, due to suitable gamma-line as well as conversion/Auger electron energies. However, adequate delivery methods are yet to be developed and accompanying radiobiological effects to be investigated, demanding the availability of $^{167}$Tm in appropriate activities and quality. [...]
2021
- Published in : Frontiers in Medicine 8 (2021) 712374
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CERN-MEDICIS: Operational indicators to support the production of new medical radionuclides by mass-separation
/ Stora, T (CERN) ; Duchemin, C (CERN) ; Andreazza, W (CERN) ; Aubert, E (CERN) ; Bernerd, C (CERN ; Leuven U.) ; Cocolios, T (Leuven U.) ; Deschamps, M (CERN) ; Dorsival, A (CERN) ; Duraffourg, M (CERN) ; Fedosseev, V (CERN) et al.
CERN-MEDICIS is an isotope mass separation facility for biomedical R&D; located in a class A laboratory, receiving up to 50% of the 1.4GeV PSB protons. It was commissioned with radioactive ion beams in 2017. [...]
2023 - 6 p.
- Published in : J. Phys. : Conf. Ser.: 2687 (2024) , no. 8, pp. 082039
- Published in : JACoW IPAC: 2023 (2023) , pp. WEPM125
Fulltext: PublicationJACoW - PDF; PublicationIOP - PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.082039
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Production of Sm-153 With Very High Specific Activity for Targeted Radionuclide Therapy
/ Van de Voorde, Michiel (SCK-CEN, Mol) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Heinke, Reinhard (Leuven U. ; CERN) ; Lambert, Laura (CERN) ; Chevallay, Eric (CERN) ; Schneider, Thomas (CERN) ; Van Stenis, Miranda (CERN) ; Cocolios, Thomas Elias (Leuven U.) ; Cardinaels, Thomas (SCK-CEN, Mol ; Leuven U.) ; Ponsard, Bernard (SCK-CEN, Mol) et al.
Samarium-153 ($^{153}$Sm) is a highly interesting radionuclide within the field of targeted radionuclide therapy because of its favorable decay characteristics. $^{153}$Sm has a half-life of 1.93 d and decays into a stable daughter nuclide ($^{153}$Eu) whereupon β − particles [E = 705 keV (30%), 635 keV (50%)] are emitted which are suitable for therapy. [...]
2021 - 9 p.
- Published in : Frontiers in Medicine 8 (2021) 675221
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Exploring the Potential of High-Molar-Activity Samarium-153 for Targeted Radionuclide Therapy with [$^{153}$Sm]Sm-DOTA-TATE
/ Vermeulen, Koen (SCK-CEN, Mol) ; Van de Voorde, Michiel (SCK-CEN, Mol) ; Segers, Charlotte (SCK-CEN, Mol) ; Coolkens, Amelie (SCK-CEN, Mol) ; Pérez, Sunay Rodriguez (SCK-CEN, Mol) ; Daems, Noami (SCK-CEN, Mol) ; Duchemin, Charlotte (Leuven U. ; CERN) ; Crabbé, Melissa (SCK-CEN, Mol) ; Opsomer, Tomas (SCK-CEN, Mol) ; Vargas, Clarita Saldarriaga (SCK-CEN, Mol) et al.
Samarium-153 is a promising theranostic radionuclide, but low molar activities (Am) resulting from its current production route render it unsuitable for targeted radionuclide therapy (TRNT). Recent efforts combining neutron activation of $^{152}$Sm in the SCK CEN BR2 reactor with mass separation at CERN/MEDICIS yielded high-Am $^{153}$Sm. [...]
2022 - 15 p.
- Published in : Pharmaceutics 14 (2022) 2566
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The CERN-MEDICIS Isotope Separator Beamline
/ CERN-MEDICIS Collaboration
CERN-MEDICIS is an off-line isotope separator facility for the extraction of radioisotopes from irradiated targets of interest to medical applications. The beamline, between the ion source and the collection chamber, consists of ion extraction and focusing elements, and a dipole magnet mass spectrometer recovered from the LISOL facility in Louvain-la-Neuve. [...]
2021 - 8 p.
- Published in : Frontiers in Medicine 8 (2021) 689281
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First laser ions at the CERN-MEDICIS facility
/ MEDICIS Collaboration
The CERN-MEDICIS facility aims to produce emerging medical radionuclides for the theranostics approach in nuclear medicine with mass separation of ion beams. To enhance the radioisotope yield and purity of collected samples, the resonance ionization laser ion source MELISSA was constructed, and provided the first laser ions at the facility in 2019. [...]
2020 - 9 p.
- Published in : Hyperfine Interact. 241 (2020) 55
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