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Active dosimetry for VHEE FLASH radiotherapy using beam profile monitors and charge measurements
/ Rieker, Vilde F (CERN ; Oslo U.) ; Corsini, Roberto (CERN) ; Stapnes, Steinar (CERN) ; Adli, Erik (Oslo U.) ; Farabolini, Wilfrid (CERN) ; Grilj, Veljko (SUBATECH, Nantes) ; Sjobak, Kyrre N (Oslo U.) ; Wroe, Laurence M (CERN) ; Aksoy, Avni (CERN ; Ankara U.) ; Robertson, Cameron S (Oxford U.) et al.
The discovery of the FLASH effect has revealed a high potential for treating cancer more efficiently by sparing
healthy tissue. The surge in related medical research activities over the last couple of years has triggered a
demand for technology with the capability of generating and measuring ionizing radiation at ultra-high doserates (UHDR). [...]
2024 - 12 p.
- Published in : Nucl. Instrum. Methods Phys. Res., A 1069 (2024) 169845
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Real-time Plastic Scintillation Dosimetry of Ultra-High Dose Rate Very High Energy Electrons (VHEE) at CERN CLEAR Facility
/ Giguère, Cloé (Laval U.) ; Hart, Alexander (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfrid (CERN) ; LeChasseur, Yoan (McGill U.) ; Bazalova-Carter, Magdalena (Victoria U.) ; Beaulieu, Luc (Laval U.)
Very High Energy Electrons (VHEE) that can theoretically treat deep-seated tumours and be delivered at ultra-high dose rates (UHDR) could be the solution to translate FLASH radiotherapy into the clinic. Standard dosimeters have limited application in those extreme conditions, but dose-rate independent and fast-response plastic scintillation detectors (PSDs) are a potential alternative to overcome this. [...]
2024 - 4 p.
- Published in : J. Phys. : Conf. Ser. 2799 (2024) 012016
Fulltext: PDF;
In : 13th International Conference on 3D dosimetry (IC3DDose 2024), Aarhus, Denmark, 17 - 19 Jun 2024, pp.012016
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VHEE FLASH sparing effect measured at CLEAR, CERN with DNA damage of pBR322 plasmid as a biological endpoint
/ Wanstall, Hannah C (Manchester U. ; Daresbury) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfred (CERN) ; Corsini, Roberto (CERN) ; Bateman, Joseph J (Oxford U., Theor. Phys.) ; Rieker, Vilde (CERN ; Oslo U.) ; Hemming, Abigail (U. Manchester (main)) ; Henthorn, Nicholas T (U. Manchester (main) ; Manchester U.) ; Merchant, Michael J (Manchester U.) ; Santina, Elham (Manchester U.) et al.
Ultra-high dose rate (UHDR) irradiation has been shown to have a sparing effect on healthy tissue, an effect known as ‘FLASH’. This effect has been studied across several radiation modalities, including photons, protons and clinical energy electrons, however, very little data is available for the effect of FLASH with Very High Energy Electrons (VHEE). [...]
2024 - 13 p.
- Published in : Sci. Rep. 14 (2024) 14803
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Plastic Scintillator Dosimetry of Ultrahigh Dose-Rate 200 MeV Electrons at CLEAR
/ Hart, Alexander (Victoria U.) ; Giguère, Cloé (Laval U.) ; Bateman, Joseph (Oxford U.) ; Korysko, Pierre (Oxford U.) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Esplen, Nolan (Victoria U.) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (Oxford U.) ; Beaulieu, Luc (Laval U.) et al.
Very-high-energy electron (VHEE) beams with energies greater than 100 MeV may be promising candidates for FLASH radiotherapy due to their favorable dose distributions and accessibility of ultrahigh dose rates (UHDRs). Combining VHEE with the normal tissue-sparing FLASH effect of UHDR radiotherapy could improve patient outcomes. [...]
2024 - 9 p.
- Published in : IEEE Sensors J. 24 (2024) 14229-14237
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Development of a novel fibre optic beam profile and dose monitor for very high energy electron radiotherapy at ultrahigh dose rates
/ Bateman, Joseph J (JAI, UK) ; Buchanan, Emma (CERN) ; Corsini, Roberto (CERN) ; Farabolini, Wilfrid (CERN) ; Korysko, Pierre (JAI, UK ; CERN) ; Larsen, Robert Garbrecht (CERN ; Groningen U.) ; Malyzhenkov, Alexander (CERN) ; Ruiz, Iñaki Ortega (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Gerbershagen, Alexander (Groningen U.)
Objective. Very high energy electrons (VHEE) in the range of 50–250 MeV are of interest for treating deep-seated tumours with FLASH radiotherapy (RT). [...]
2024 - 16 p.
- Published in : Phys. Med. Biol. 69 (2024) 085006
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Mini-GRID radiotherapy on the CLEAR very-high-energy electron beamline: collimator optimization, film dosimetry, and Monte Carlo simulations
/ Clements, Nathan (Victoria U.) ; Esplen, Nolan (Victoria U.) ; Bateman, Joseph (Oxford U.) ; Robertson, Cameron (Oxford U.) ; Dosanjh, Manjit (Oxford U. ; CERN) ; Korysko, Pierre (Oxford U. ; CERN) ; Farabolini, Wilfrid (CERN) ; Corsini, Roberto (CERN) ; Bazalova-Carter, Magdalena (Victoria U.)
Objective. Spatially-fractionated radiotherapy (SFRT) delivered with a very-high-energy electron (VHEE) beam and a mini-GRID collimator was investigated to achieve synergistic normal tissue-sparing through spatial fractionation and the FLASH effect. [...]
2024 - 17 p.
- Published in : Phys. Med. Biol. 69 (2024) 055003
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A novel fibre optic monitor for VHEE UHDR beam monitoring: first tests at CLEAR
/ Bateman, Joseph (JAI, UK ; CERN) ; Buchanan, Emma (CERN) ; Corsini, Roberto (CERN) ; Gerbershagen, Alexander (Groningen U.) ; Ortega Ruiz, Inaki (CERN) ; Dosanjh, Manjit (JAI, UK ; CERN) ; Farabolini, Wilfrid (CERN) ; Rieker, Vilde (CERN ; Oslo U.) ; Korysko, Pierre (JAI, UK ; CERN) ; Malyzhenkov, Alexander (CERN)
Beam monitoring for Ultra High Dose Rate (UHDR) radiation therapy using pulsed beams, i.e. Very High Energy Electrons (VHEE), is a major challenge. [...]
2023
- Published in : JACoW IPAC 2023 (2023) THPL041
Fulltext: PDF;
In : 14th International Particle Accelerator Conference (IPAC 2023), Venice, Italy, 7 - 12 May 2023, pp.THPL041
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VHEE High Dose Rate Dosimetry Studies in CLEAR
/ Rieker, Vilde (CERN) ; Bateman, Joseph (JAI, UK ; CERN) ; Corsini, Roberto (CERN) ; Dyks, Luke (CERN ; Oxford U.) ; Farabolini, Wilfrid (IRFU, Saclay) ; Korysko, Pierre (Oxford U. ; CERN)
The 200 MeV electron beam of the CERN Linear Accelerator for Research (CLEAR) user facility at CERN has been intensively used to study the potential use of Very High Energy Electrons (VHEE) in cancer radiotherapy. In particular, irradiation tests have been performed in the high dose rate regime, which has gained a lot of interest for the so called FLASH biological effect, in which cancer cells are damaged while healthy tissue is largely spared. [...]
2022 - 4 p.
- Published in : JACoW IPAC 2022 (2022) 3026-3029
Fulltext: PDF;
In : 13th International Particle Accelerator Conference (IPAC 2022), Bangkok, Thailand, 12 - 17 Jun 2022, pp.3026-3029
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Testing the Properties of Beam-Dose Monitors for VHEE-FLASH Radiation Therapy
/ Bateman, Joseph (JAI, UK) ; Burrows, Philip (JAI, UK) ; Corsini, Roberto (CERN) ; Dosanjh, Manjit (CERN) ; Dyks, Luke (JAI, UK) ; Farabolini, Wilfrid (CERN) ; Gerbershagen, Alexander (CERN) ; Heracleous, Natalie (CERN) ; Korysko, Pierre (CERN) ; Morales Vigo, Sara (CERN) et al.
Very High Energy Electrons (VHEE) of 50 - 250 MeV are an attractive choice for FLASH radiation therapy (RT). Before VHEE-FLASH RT can be considered for clinical use, a reliable dosimetric and beam monitoring system needs to be developed, able to measure the dose delivered to the patient in real-time and cut off the beam in the event of a machine fault to prevent overdosing the patient. [...]
2022 - 4 p.
- Published in : JACoW IPAC 2022 (2022) 3018-3021
Fulltext: PDF;
In : 13th International Particle Accelerator Conference (IPAC 2022), Bangkok, Thailand, 12 - 17 Jun 2022, pp.3018-3021
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