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  1. Here, we investigated the potential interaction between bromodomain-containing protein 4 (BRD4), an established epigenetic modulator and transcriptional coactivator, and p63, a member of the p53 transcription ...

    Authors: E. Foffi, A. Violante, R. Pecorari, A. M. Lena, F. Rugolo, G. Melino and E. Candi
    Citation: Biology Direct 2024 19:124
    Content type: Research Published on:

  2. Osteoporosis, a metabolic disorder, remains challenging to treat due to limited understanding of its underlying mechanism. The annual cycle of “cyclic physiological osteoporosis (CPO)” and its full reversal in...

    Authors: Chunyi Li, Wenying Wang, Guokun Zhang, Hengxing Ba, He Liu, Jincheng Wang, Wei Li, Gerry Melino and Yufang Shi
    Citation: Biology Direct 2024 19:123
    Content type: Review Published on:

  3. RNA methylation, an important reversible post-transcriptional modification in eukaryotes, has emerged as a prevalent epigenetic alteration. However, the role of the m6A reader YTH domain family 2 (YTHDF2) has ...

    Authors: Bao Dai, Lei Xu, Shikuo Rong, Muye Song, Ziteng Lan, Weijian Chen, Lingyun Zhang, Yongchen Liu, Linhe Wang, Jinghua Li, Jian Chen and Zeyu Wu
    Citation: Biology Direct 2024 19:122
    Content type: Research Published on:

  4. Preeclampsia (PE) is a severe pregnancy complication characterized by complex molecular interactions. Understanding these interactions is crucial for developing effective therapeutic strategies.

    Authors: Xiaohua Luo, Xiaopei Guo, Ningning Chen, Rui Peng, Ci Pan, Zhuyin Li, Bing Zhao, Ruonan Ji and Siyu Li
    Citation: Biology Direct 2024 19:121
    Content type: Research Published on:

  6. Telomeres are pivotal determinants of cell stemness, organismal aging, and lifespan. Herein, we examined similarities in telomeres of Arabidopsis thaliana, mice, and humans. We report the common traits, which inc...

    Authors: Edison Di Pietro, Romina Burla, Mattia La Torre, Mary-Paz González-García, Raffaele Dello Ioio and Isabella Saggio
    Citation: Biology Direct 2024 19:119
    Content type: Review Published on:

  7. Hepatocellular carcinoma (HCC) ranks among the most lethal malignancies around the world. However, the current management strategies for predicting prognosis in HCC patients remain unreliable. Our study develo...

    Authors: Hao Xu, Hui Pan, Lian Fang, Cangyuan Zhang, Chen Xiong and Weiti Cai
    Citation: Biology Direct 2024 19:118
    Content type: Research Published on:

  8. Sepsis is a severe condition characterized by multiple organ dysfunction resulting from an imbalanced host immune response to infections. miRNAs play a crucial role in regulating various biological processes. ...

    Authors: Yu Zhou, Yuan Yuan, Xuanqi Yao, Lin Wang, Liangfang Yao, Daolin Tang, Feng Chen and Jinbao Li
    Citation: Biology Direct 2024 19:117
    Content type: Research Published on:

  9. Tumor Mutational Burden (TMB) have emerged as pivotal predictive biomarkers in determining prognosis and response to immunotherapy in colorectal cancer (CRC) patients. While Whole Exome Sequencing (WES) stands...

    Authors: Yangyang Fang, Tianmei Fu, Qian Zhang, Ziqing Xiong, Kuai Yu and Aiping Le
    Citation: Biology Direct 2024 19:116
    Content type: Research Published on:

  10. Laryngeal cancer (LCA) is one of the most common head and neck squamous cell carcinoma with poor outcome. LCA stem cells are the main reason for LCA therapy resistance and relapse. Understanding the molecular ...

    Authors: Wenlin Liu, Jie Wu, Yuanpu Lai, Siyi Zhang, Ankui Yang, Yixuan Li, Cuifang Chen and Zhongming Lu
    Citation: Biology Direct 2024 19:115
    Content type: Research Published on:

  12. Gliomas represent a highly aggressive class of tumors located in the brain. Despite the availability of multiple treatment modalities, the prognosis for patients diagnosed with glioma remains unfavorable. Ther...

    Authors: Suyin Feng, Long Zhu, Yan Qin, Kun Kou, Yongtai Liu, Guangmin Zhang, Ziheng Wang, Hua Lu and Runfeng Sun
    Citation: Biology Direct 2024 19:113
    Content type: Research Published on:

  13. Precise regulation of gene expression is crucial to development. Enhancers, the core of gene regulation, determine the spatiotemporal pattern of gene transcription. Since many disease-associated mutations are ...

    Authors: Junyou Zhang, Qilin Wang, Jiaxin Liu, Yingying Duan, Zhaoshuo Liu, Ziyi Zhang and Chunyan Li
    Citation: Biology Direct 2024 19:112
    Content type: Review Published on:

  14. Dysregulated androgen receptor (AR) activity is central to various diseases, particularly prostate cancer (PCa), in which it drives tumour initiation and progression. Consequently, antagonising AR activity via...

    Authors: Justus S. Israel, Laura-Maria Marcelin, Sherif Mehralivand, Jana Scholze, Jörg Hofmann, Matthias B. Stope, Martin Puhr, Christian Thomas and Holger H. H. Erb
    Citation: Biology Direct 2024 19:111
    Content type: Research Published on:

  15. Hepatocellular carcinoma (HCC) is one of the most common as well as leading causes of mortality worldwide, and sorafenib is the first-line treatment in HCC patients. Unfortunately, drug resistance to sorafenib...

    Authors: Xiangbo Huang, Nan Yi, Pengfei Zhu, Jian Gao and Jun Lv
    Citation: Biology Direct 2024 19:110
    Content type: Research Published on:

  16. MicroRNAs (miRNAs) are critical regulators of cancer progression, prompting our investigation into the specific function of miR-630 in pancreatic cancer stem cells (PCSCs). Analysis of miRNA and mRNA expressio...

    Authors: Jun Zou, Sha Yang, Chongwu He, Lei Deng, Bangran Xu and Shuai Chen
    Citation: Biology Direct 2024 19:109
    Content type: Research Published on:

  18. Biosynthesis of 17β-estradiol (E2) is a crucial ovarian function in mammals, which is essential for follicular development and pregnancy outcome. Exploring the epigenetic regulation of E2 synthesis is benefici...

    Authors: Zhennan Guo, Qiang Zeng, Qiqi Li, Baosen Shan, Yangan Huo, Xiaoli Shi, Qifa Li and Xing Du
    Citation: Biology Direct 2024 19:107
    Content type: Research Published on:

  20. Centrosomal protein of 55 kDa (CEP55) overexpression has been linked to tumor stage, aggressiveness of the tumor, poor prognosis, and metastasis. This study aims to elucidate the action of CEP55 in ovarian can...

    Authors: Junhui Yu, Xing Chen, Xiaoxiao Ding, Kang Lin, Tianxin Zhang and Kai Wang
    Citation: Biology Direct 2024 19:105
    Content type: Research Published on:

  21. The growing body of evidence suggests that RNA-binding proteins (RBPs) have an important function in cancer biology. This research characterizes the expression status of fragile X-related protein 1 (FXR1) in e...

    Authors: Faiz Ali Khan, Dalia Fouad, Farid S. Ataya, Na Fang, Jingcheng Dong and Shaoping Ji
    Citation: Biology Direct 2024 19:104
    Content type: Research Published on:

  22. Accurately identifying effective biomarkers and translating them into clinical practice have significant implications for improving clinical outcomes in hepatocellular carcinoma (HCC). In this study, our objec...

    Authors: Xiaokai Yan, Yao Qi, Xinyue Yao, Lulu Yin, Hao Wang, Ji Fu, Guo Wan, Yanqun Gao, Nanjing Zhou, Xinxin Ye, Xiao Liu and Xing Chen
    Citation: Biology Direct 2024 19:103
    Content type: Research Published on:

  23. The role of the RING finger protein superfamily in carcinogenesis has been widely studied, but one member of this family, RNF19A, has not yet been thoroughly explored in bladder cancer (BCa).

    Authors: Hao Deng, Guanghai Ji, Jun Ma, Jun Cai, Shaoping Cheng and Fan Cheng
    Citation: Biology Direct 2024 19:102
    Content type: Research Published on:

  24. Identifying therapeutic inhibitors of crucial enzymes involved in the peptidoglycan biosynthesis pathway is pivotal for developing new treatments against multidrug-resistant Enterococcus faecalis V583. MurM, an e...

    Authors: Km.Rakhi, Monika Jain, Amit Kumar Singh, Mohd Sajid Ali, Hamad A. Al-Lohedan and Jayaraman Muthukumaran
    Citation: Biology Direct 2024 19:101
    Content type: Research Article Published on:

  25. Alzheimer’s disease (AD) is a complex neurodegenerative disorder significantly impairing cognitive faculties, memory, and physical abilities. To characterize the modulation of the gut microbiota in an in vivo ...

    Authors: Francesco Favero, Angela Re, Mohammed Salim Dason, Teresa Gravina, Mara Gagliardi, Marta Mellai, Marco Corazzari and Davide Corà
    Citation: Biology Direct 2024 19:100
    Content type: Research Published on:

  26. This study aimed to elucidate the role and underlying mechanisms of Peroxisome proliferator-activated receptor gamma (PPARγ) and its m6A methylation in renal ischemia-reperfusion (I/R) injury and ferroptosis o...

    Authors: Wei Liu, Ziqing Xiong, Tianmei Fu, Juan Yang, Juan Zou, Yize Wu, Linju Kuang, Qian Wang, Song Li and Aiping Le
    Citation: Biology Direct 2024 19:99
    Content type: Research Published on:

  27. Spiroplasma eriocheiris has been proved to be a pathogen causing tremor disease of Eriocheir sinensis, it is also infectious to other aquatic crustaceans, resulting in a serious threat on the sustainable developm...

    Authors: Rong Li, Xiaohui Cao, Jiaxin Chen, Tingting He, Yan Zhang, Wen Wang, Yaqi Wang, Yifei Wang, Yanyan Qiu, Mengji Xie, Kailin Shi, Yuhua Xu, Siyuan Zhang and Peng Liu
    Citation: Biology Direct 2024 19:98
    Content type: Research Published on:

  28. Disulfidptosis refers to cell death caused by the accumulation and bonding of disulfide in the cytoskeleton protein of SLC7A11-high level cells under glucose deprivation. However, the role of disulfidptosis-re...

    Authors: Zhen Kang, Zheng-Hua Wan, Rui-Cheng Gao, Dong-Ning Chen, Qing-Shui Zheng, Xue-Yi Xue, Ning Xu and Yong Wei
    Citation: Biology Direct 2024 19:97
    Content type: Research Published on:

  29. Vaginal infections caused by multidrug-resistant pathogens such as Candida albicans and Gardnerella spp. represent a significant health challenge. Current treatments often fail because of resistance and toxicity....

    Authors: Ling Fang, Tiancheng Yang, Haojue Wang and Jun Cao
    Citation: Biology Direct 2024 19:96
    Content type: Research Published on:

  31. Lung cancer is one of the most frequent cancers and the leading cause of cancer-related deaths worldwide with poor prognosis. A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) is cruci...

    Authors: Wei Zhai, Wensheng Yang, Jing Ge, Xuelian Xiao, Kang Wu, Kelin She, Yu Zhou, Yi Kong, Lin Wu, Shiya Luo and Xingxiang Pu
    Citation: Biology Direct 2024 19:94
    Content type: Research Published on:

  32. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is reliably one of the largest pandemics the world has suffered in recent years. In the search for non-biological antivirals, special emphasis w...

    Authors: Michela Murdocca, Osvaldo Andrade Santos-Filho, Claudia De Masi, Edivaldo dos Santos Rodrigues, Claudia Valeria Campos de Souza, Riccardo De Santis, Donatella Amatore, Andrea Latini, Rossella Schipani, Lino di Rienzo Businco, Bruno Brandimarte, Giorgia Grilli, Tien L Huang, Annie S Mayence, Florigio Lista, Andrea Duranti…
    Citation: Biology Direct 2024 19:93
    Content type: Research Published on:

  33. Ischemia/reperfusion (I/R) injury is a severe brain disorder with currently limited effective treatments. This study aims to explore the role of N6-methyladenosine (m6A) modification and associated regulatory ...

    Authors: Zhengtao Yu, Ying Xia, Jiameng Li, Junwen Jiang, You Li, Youjun Li and Liu Wang
    Citation: Biology Direct 2024 19:92
    Content type: Research Published on:

  34. The complex network governing self-renewal in epidermal stem cells (EPSCs) is only partially defined. FOXM1 is one of the main players in this network, but the upstream signals regulating its activity remain t...

    Authors: Maria Pia Polito, Alessio Romaldini, Lorenzo Tagliazucchi, Grazia Marini, Federica Radice, Gaia Andrea Gozza, Giulia Bergamini, Maria Paola Costi and Elena Enzo
    Citation: Biology Direct 2024 19:91
    Content type: Research Published on:

  35. miR-210 is one of the most evolutionarily conserved microRNAs. It is known to be involved in several physiological and pathological processes, including response to hypoxia, angiogenesis, cardiovascular diseas...

    Authors: Davide Colaianni, Federico Virga, Annamaria Tisi, Chiara Stefanelli, Germana Zaccagnini, Paola Cusumano, Gabriele Sales, Mihai Bogdan Preda, Fabio Martelli, Daniela Taverna, Massimiliano Mazzone, Cristiano Bertolucci, Rita Maccarone and Cristiano De Pittà
    Citation: Biology Direct 2024 19:90
    Content type: Research Published on:

  36. Endometrial cancer (EC) presents significant clinical challenges due to its heterogeneity and complex pathophysiology. SAMHD1, known for its role as a deoxynucleotide triphosphate triphosphohydrolase, has been...

    Authors: Ping Qiang, Ying Chen, Yang Shao, Qicheng Deng, Songyuan Xu and Weipei Zhu
    Citation: Biology Direct 2024 19:89
    Content type: Research Published on:

  37. Motile Sperm Domain-Containing Protein 1 (MOSPD1) has been implicated in breast cancer (BC) pathophysiology, but its exact role remains unclear. This study aimed to assess MOSPD1 expression levels in BC versus...

    Authors: Yiling Jiang, Hailong Li, Sixuan Wu, Baohong Jiang, Lijun Zeng, Yuanbin Tang, Lunqi Luo, Lianjie Ouyang, Wei Du and Yuehua Li
    Citation: Biology Direct 2024 19:88
    Content type: Research Published on:

  38. Plants have an amazing ability to adapt to their environment, and this extends beyond biochemical responses and includes developmental changes that help them better exploit resources and survive. The plasticit...

    Authors: Kavya Yalamanchili, Joop E. M. Vermeer, Ben Scheres and Viola Willemsen
    Citation: Biology Direct 2024 19:87
    Content type: Review Published on:

  39. The immune response gene 1 (IRG1) and its metabolite itaconate are implicated in modulating inflammation and oxidative stress, with potential relevance to sepsis-induced myocardial dysfunction (SIMD). This stu...

    Authors: Song Shen, Jianhui Li, Zhonghai Wei, Yihai Liu, Lina Kang, Rong Gu, Xuan Sun, Biao Xu and QiaoLing Li
    Citation: Biology Direct 2024 19:86
    Content type: Research Published on:

  40. Skin healing is a complex and dynamic physiological process that follows mechanical alteration of the skin barrier. Under normal conditions, this complex process can be divided into at least three continuous a...

    Authors: S. Gandolfi, A. Sanouj, B. Chaput, A. Coste, B. Sallerin and A. Varin
    Citation: Biology Direct 2024 19:85
    Content type: Review Published on:

  42. Breast cancer (BC) is a great clinical challenge because of its aggressiveness and poor prognosis. Zinc Finger Protein 64 (ZFP64), as a transcriptional factor, is responsible for the development and progressio...

    Authors: Jiayi Sun, Jinquan Liu, Yudong Hou, Jianheng Bao, Teng Wang, Longbi Liu, Yidan Zhang, Rui Zhong, Zhenxuan Sun, Yan Ye and Jintao Liu
    Citation: Biology Direct 2024 19:83
    Content type: Research Published on:

  44. Limited supply of certain nutrients and deregulation of nucleus pulposus (NP) plays a key role in the pathogenesis of intervertebral disc degeneration (IVDD). However, whether nutrient deprivation-induced cell...

    Authors: Shaobo Wu, Jin Wang, Minglin Wang, Kaisheng Zhou, Dageng Huang, Yilei Zhang and Haihong Zhang
    Citation: Biology Direct 2024 19:81
    Content type: Research Published on:

  46. Esophageal squamous cell carcinoma (ESCC) is often diagnosed at advanced stages due to the inherent limitations of current screening methodologies. Central to evaluating tumor invasion and prognostic assessmen...

    Authors: Han Zhang, Xia Zhang, Zhenyu Huang and Hao Zhang
    Citation: Biology Direct 2024 19:79
    Content type: Research Published on:

  47. Choriocarcinoma is a malignant cancer that belongs to gestational trophoblastic neoplasia (GTN). Herein, serum metabolomic analysis was performed on 29 GTN patients and 30 healthy individuals to characterize t...

    Authors: Xiao-Mei Liu, Zi-Hao Wang, Qian-Xue Wei, Yang Song and Xiao-Xin Ma
    Citation: Biology Direct 2024 19:78
    Content type: Research Published on:

  48. GALNTs (UDP-GalNAc; polypeptide N-acetylgalactosaminyltransferases) initiate mucin-type O-GalNAc glycosylation by adding N-GalNAc to protein serine/threonine residues. Abnormalities in O-GalNAc glycosylation a...

    Authors: Yuanwen Peng, Jun Liu, Lili Sun, Qiuying Zheng, Can Cao, Wenyong Ding, Shufeng Yang, Li Ma and Wenli Zhang
    Citation: Biology Direct 2024 19:77
    Content type: Research Published on:

  49. Moyamoya disease, characterized by basal cerebral artery obstruction, was studied for differential protein expression to elucidate its pathogenesis. Proteomic analysis of cerebrospinal fluid from 10 patients, ...

    Authors: Dong Guo, Yang Dong, Hongbin Li, Hongwei Li and Bo Yang
    Citation: Biology Direct 2024 19:76
    Content type: Research Published on:

  50. Gastrin is a gastrointestinal peptide hormone that plays an important role in the progression of colorectal cancer (CRC). However, the molecular mechanism remains unclear. In this study, we identified gastrin-...

    Authors: Xu Wang, Tianjiao Sun, Jiapeng Fan, Xueliang Zuo and Jiading Mao
    Citation: Biology Direct 2024 19:75
    Content type: Research Published on:
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