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DALK: Dynamic Co-Augmentation of LLMs and KG to answer Alzheimer’s Disease Questions with Scientific Literature

Dawei Li, Shu Yang, Zhen Tan, Jae Young Baik, Sukwon Yun, Joseph Lee, Aaron Chacko, Bojian Hou, Duy Duong-Tran, Ying Ding, Huan Liu, Li Shen, Tianlong Chen


Abstract
Recent advancements in large language models (LLMs) have achieved promising performances across various applications. Nonetheless, the ongoing challenge of integrating long-tail knowledge continues to impede the seamless adoption of LLMs in specialized domains. In this work, we introduce DALK, a.k.a. Dynamic Co-Augmentation of LLMs and KG, to address this limitation and demonstrate its ability on studying Alzheimer’s Disease (AD), a specialized sub-field in biomedicine and a global health priority. With a synergized framework of LLM and KG mutually enhancing each other, we first leverage LLM to construct an evolving AD-specific knowledge graph (KG) sourced from AD-related scientific literature, and then we utilize a coarse-to-fine sampling method with a novel self-aware knowledge retrieval approach to select appropriate knowledge from the KG to augment LLM inference capabilities. The experimental results, conducted on our constructed AD question answering (ADQA) benchmark, underscore the efficacy of DALK. Additionally, we perform a series of detailed analyses that can offer valuable insights and guidelines for the emerging topic of mutually enhancing KG and LLM.
Anthology ID:
2024.findings-emnlp.119
Volume:
Findings of the Association for Computational Linguistics: EMNLP 2024
Month:
November
Year:
2024
Address:
Miami, Florida, USA
Editors:
Yaser Al-Onaizan, Mohit Bansal, Yun-Nung Chen
Venue:
Findings
SIG:
Publisher:
Association for Computational Linguistics
Note:
Pages:
2187–2205
Language:
URL:
https://aclanthology.org/2024.findings-emnlp.119
DOI:
Bibkey:
Cite (ACL):
Dawei Li, Shu Yang, Zhen Tan, Jae Young Baik, Sukwon Yun, Joseph Lee, Aaron Chacko, Bojian Hou, Duy Duong-Tran, Ying Ding, Huan Liu, Li Shen, and Tianlong Chen. 2024. DALK: Dynamic Co-Augmentation of LLMs and KG to answer Alzheimer’s Disease Questions with Scientific Literature. In Findings of the Association for Computational Linguistics: EMNLP 2024, pages 2187–2205, Miami, Florida, USA. Association for Computational Linguistics.
Cite (Informal):
DALK: Dynamic Co-Augmentation of LLMs and KG to answer Alzheimer’s Disease Questions with Scientific Literature (Li et al., Findings 2024)
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PDF:
https://aclanthology.org/2024.findings-emnlp.119.pdf