호모 사피엔스 종의 단백질 코드 유전자
ILF3 식별자 에일리어스 ILF3 외부 ID OMIM : 603182 MGI : 1339973 HomoloGene : 7785 GenCard : ILF3 맞춤법 종. 인간 마우스 엔트레즈 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 장소(UCSC) Chr 19: 10.65 ~10.69 Mb Chr 9: 21.28 ~21.32 Mb PubMed 검색[3] [4] 위키데이터
인터류킨 인핸서 결합인자 3은 ILF3 [5] [6] 단백질 이다.
기능. 활성화된 T세포의 핵인자(NFAT)는 인터류킨2의 T세포 발현에 필요한 전사인자이며, NFAT는 항원수용체 응답요소2로 알려진 IL2 인핸서 내의 배열에 결합한다. 또한 NFAT는 RNA를 결합할 수 있으며 B형 간염 바이러스 중합효소의 캡슐화 및 단백질 프라이밍에 필수적인 성분이다. NFAT는 45kDa와 90kDa 단백질의 헤테로다이머이며, 그 중 더 큰 것이 이 유전자의 산물이다. 리보솜에 주로 국소화된 암호화 단백질은 아마도 mRNA 신장 수준에서 전사를 조절한다. 이 [7]
상호 작용 ILF3는 다음과 상호작용하는 것 으로 나타났습니다.
소형 NF90/ILF3 관련 RNA(snaR)(길이 약 120 뉴클레오티드)로 ILF3 이중가닥 RNA 결합 [17] 다른 snaR RNA는 아프리카 대인원에서 발견됩니다.[18]
ILF2와 ILF3는 루푸스 [19] [20] [21] [22]
레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000129351 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000032178 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthésy B (August 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90" . The Journal of Biological Chemistry . 269 (32): 20691–9. doi :10.1016/S0021-9258(17)32048-3 PMID 7519613 . ^ Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L, Westendorf JM (September 1996). "Identification of novel M phase phosphoproteins by expression cloning" . Molecular Biology of the Cell . 7 (9): 1455–69. doi :10.1091/mbc.7.9.1455 . 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