지방산 결합 단백질 7, 뇌 (FabP7 ; 또한 뇌 지질 결합 단백질 , BLBP )는 인간의 유전자 다.[5]
함수 이 유전자가 인코딩한 단백질은 뇌지방산 결합 단백질이다. 지방산 결합 단백질 (FABPs)은 장체인 지방산과 기타 소수성 리간드를 결합하는 작고 보존성이 높은 세포질 단백질 이다.FABP는 지방산 섭취, 운반, 신진대사의 역할을 하는 것으로 생각된다.[5]
FABP7은 개발 중 에 노치 수용체의 활성화에 의해 방사상 글리아로 표현된다.[6] 릴린 은 노치-1 활성화를 통해 신경 세포 에서 FABP7 발현을 유도하는 것으로 나타났다.[7]
한 연구에 따르면, FABP7은 모든 FABP 중에서 가장 높은 친화력으로 DHA 를 결합한다.[8]
배아 16일(왼쪽)과 산후 0일(오른쪽)에 쥐의 뇌에 있는 Fabp7 단백질의 표현. 두 단계 모두에서 팹7은 신경생성 이 두드러지는 심실존과 방사상 글리아 에서 강하게 발현된다. 병리학에서의 역할 FabP7은 메타분석에 의해 확증된 조현병 연계 영역인 인간 염색체 6q22.31에 매핑된다.[9]
2008년 현재 조현병 의 가능한 위험유전자로서 FABP7에 대해 두 가지 연구가 진행되어 왔으며,[10] [11] [12] 후자의 연구에서 유전자의 영향은 남성에게 더 강했다. 이 연구는 또한 FABP7 변동을 마우스에서의 약한 전치 억제 와 연관시켰다; PPI의 결핍은 조현병 환자와 그 친척들에게서 관찰되는 내피성적 특성이다.
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"Ligand specificity of brain lipid-binding protein" . The Journal of Biological Chemistry . 271 (40): 24711–9. doi :10.1074/jbc.271.40.24711 PMID 8798739 . ^ Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, Schwab SG, Pulver AE, Faraone SV, Brzustowicz LM, Kaufmann CA, Garver DL, Gurling HM, Lindholm E, Coon H, Moises HW, Byerley W, Shaw SH, Mesen A, Sherrington R, O'Neill FA, Walsh D, Kendler KS, Ekelund J, Paunio T, Lönnqvist J, Peltonen L, O'Donovan MC, Owen MJ, Wildenauer DB, Maier W, Nestadt G, Blouin JL, Antonarakis SE, Mowry BJ, Silverman JM, Crowe RR, Cloninger CR, Tsuang MT, Malaspina D, Harkavy-Friedman JM, Svrakic DM, Bassett AS, Holcomb J, Kalsi G, McQuillin A, Brynjolfson J, Sigmundsson T, Petursson H, Jazin E, Zoëga T, Helgason T (Jul 2003). "Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia" . American Journal of Human Genetics . 73 (1): 34–48. doi :10.1086/376549 . PMC 1180588 PMID 12802786 . ^ Gene Overview of All Published 조현병-SJGene database for FABP7 - SZGene database for Generation Research Forum 웹사이트에 게시.^ Jungerius BJ, Hoogendoorn ML, Bakker SC, Van't Slot R, Bardoel AF, Ophoff RA, Wijmenga C, Kahn RS, Sinke RJ (Nov 2008). "An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia" . Molecular Psychiatry . 13 (11): 1060–8. doi :10.1038/sj.mp.4002080 PMID 17893707 . ^ Watanabe A, Toyota T, Owada Y, Hayashi T, Iwayama Y, Matsumata M, Ishitsuka Y, Nakaya A, Maekawa M, Ohnishi T, Arai R, Sakurai K, Yamada K, Kondo H, Hashimoto K, Osumi N, Yoshikawa T (Nov 2007). "Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype" . PLOS Biology . 5 (11): e297. doi :10.1371/journal.pbio.0050297 . PMC 2071943 PMID 18001149 . 추가 읽기 Börchers T, Hohoff C, Buhlmann C, Spener F (Jul 1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation". 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"Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1354 (1): 24–8. doi :10.1016/S0167-4781(97)00115-2 . PMID 9375786 . Godbout R, Bisgrove DA, Shkolny D, Day RS (Apr 1998). "Correlation of B-FABP and GFAP expression in malignant glioma" . Oncogene . 16 (15): 1955–62. doi :10.1038/sj.onc.1201740 PMID 9591779 . Pu L, Igbavboa U, Wood WG, Roths JB, Kier AB, Spener F, Schroeder F (Aug 1999). "Expression of fatty acid binding proteins is altered in aged mouse brain". Molecular and Cellular Biochemistry . 198 (1–2): 69–78. doi :10.1023/A:1006946027619 . PMID 10497880 . S2CID 6180992 . Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC (Sep 2000). "Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein" . The Journal of Biological Chemistry . 275 (35): 27045–54. doi :10.1074/jbc.M003001200 PMID 10854433 . Rademacher M, Zimmerman AW, Rüterjans H, Veerkamp JH, Lücke C (Oct 2002). "Solution structure of fatty acid-binding protein from human brain". Molecular and Cellular Biochemistry . 239 (1–2): 61–8. doi :10.1023/A:1020566909213 . PMID 12479569 . S2CID 24296178 . Miller SJ, Li H, Rizvi TA, Huang Y, Johansson G, Bowersock J, Sidani A, Vitullo J, Vogel K, Parysek LM, DeClue JE, Ratner N (Mar 2003). "Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis" . Molecular and Cellular Biology . 23 (6): 2213–24. doi :10.1128/MCB.23.6.2213-2224.2003 . PMC 149461 PMID 12612091 . Sánchez-Font MF, Bosch-Comas A, Gonzàlez-Duarte R, Marfany G (Jun 2003). "Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance" . Nucleic Acids Research . 31 (11): 2769–77. doi :10.1093/nar/gkg396 . PMC 156729 PMID 12771203 . Wang M, Liu YE, Goldberg ID, Shi YE (Nov 2003). "Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG" . The Journal of Biological Chemistry . 278 (47): 47319–25. doi :10.1074/jbc.M308131200 PMID 12975368 . Liang Y, Diehn M, Watson N, Bollen AW, Aldape KD, Nicholas MK, Lamborn KR , Berger MS, Botstein D, Brown PO, Israel MA (Apr 2005). "Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme" . Proceedings of the National Academy of Sciences of the United States of America . 102 (16): 5814–9. Bibcode :2005PNAS..102.5814L . doi :10.1073/pnas.0402870102 PMC 556127 PMID 15827123 . Liang Y, Bollen AW, Aldape KD, Gupta N (2006). "Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma" . BMC Cancer . 6 : 97. doi :10.1186/1471-2407-6-97 . PMC 1479358 PMID 16623952 . 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외부 링크
PDB 갤러리
1fdq : 인간 뇌지방산 결합단백질의 결정구조
1fe3 : 인간 뇌지방산 결합 단백질 올레산 결정구조
1jx : 인간 뇌형 지방산 결합단백질의 용액구조
