흥분성 아미노산 트랜스포터 3

SLC1A1
식별자
별칭	SLC1A1, EAAC1, EAT3, SCZD18, DCBXA, 솔루트 캐리어 패밀리 1 멤버 1
외부 ID	OMIM: 133550 MGI: 105083 호몰로진: 20881 GeneCard: SLC1A1
유전자 위치(인간)
쳇.	9번 염색체(인간)
끝	4,587,469 bp
유전자 위치(마우스)
쳇.	19번 염색체(쥐)
끝	28,891,360 bp
RNA 표현 패턴
	표현된 상단
	카푸트 전염병; ; 말뭉치 전염병; ; 주황 점막; ; 신장 튜울레; ; 간; ; 십이지장; ; 브로드만 구역 46;
	추가 참조 표현식 데이터
	; ;
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	시스틴 트랜섬브레인 트랜스포터 활동; GO:0001948 단백질 결합; 심포터 활동; L-글루탐산 투과형 트랜스포터 활동; 글루타민 제본; 아미노산 트랜섬브레인 트랜스포터 활동; 고농축 글루탐산염 투과성 트랜스포터 활동; 염화물 전달 물질 활동; 글루탐테이트:시모포터 활동을 장려하다.; 금속 이온 결합;
셀룰러 컴포넌트	막의 적분 성분; 막으로 막다; 플라즈마 막; 아피셜 플라즈마 막; 세포외 외성체; 플라스마 막의 적분 성분; 초기 내막막; 재생 내막;
생물학적 과정	화학 시냅스 전달; 혈장 막 전체에 걸친 D-aspartate 가져오기; 이온 수송; 심박수의 양성 조절; 글루타민 분비물; 시스틴 수송; 단백질 균질화; L-글루타메이트 가져오기; L-글루탐산염 트랜섬브레인 운송; 시스틴 트랜섬브레인 운송; 혈장 막 전체에 걸쳐 L-aspartate 가져오기; 염화물 투과형 운송; 혈장 막 전체에 걸친 L-글루타민산 수입; 아미노산 수송; 운송;
	출처:아미고 / 퀵고
직교체
	6505
	20510
	ENSG00000106688
	ENSMUSG00000024935
	P43005
	P51906
	NM_004170
	NM_009199
	NP_004161
	NP_033225
	위키다타
인간 보기/편집	마우스 보기/편집

흥분성 아미노산 트랜스포터 3(EAT3)은 인간에서 SLC1A1 유전자에 의해 인코딩되는 단백질이다.^[5]^[6]

조직 분포

EATH3는 뉴런의 플라스마 막, 특히 덴드라이트와 액손 단자에 표현된다.^[7]

함수

흥분성 아미노산 트랜스포터 3은 뉴런의 혈장막을 가로질러 글루탐산염을 운반하는 데 필수적인 역할을 하는 고선위 글루탐산염 트랜스포터의 일원이다.뇌에서 흥분성 아미노산 전달체는 신경전달물질 글루탐산염의 시냅스 후 작용을 종료하고 세포외 글루탐산염 농도를 신경독성 수준 이하로 유지하는 데 결정적이다.EAT3는 또한 아스파르테이트를 운반하는데, 이 유전자의 돌연변이는 글루타메이트-아스파테이트 수송결함이라고도 알려진 디카르복실성 아미노산두리아를 일으키는 것으로 생각된다.^[6]EATH3는 뉴런 사이스틴 흡수의 주요 경로이기도 하다.시스테인은 주요 항산화 글루타티온의 성분으로 EAT3가 부족한 생쥐는 뉴런의 글루타티온 수치가 감소하고 산화 스트레스가 증가하며 연령에 따른 뉴런 손실, 특히 실체니아 니그라의 뉴런을 나타낸다.메타분석은 유전자 SLC1A1의 다형성과 강박-강박 장애 사이의 작지만 유의한 연관성을 확인했다.^[8]

상호작용

SLC1A1은 ARL6IP5와 상호작용하는 것으로 나타났다.^[9]

참고 항목

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000106688 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG000024935 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith CP, Weremowicz S, Kanai Y, Stelzner M, Morton CC, Hediger MA (March 1994). "Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders". Genomics. 20 (2): 335–6. doi:10.1006/geno.1994.1183. PMID 8020993.
^ ^a ^b "Entrez Gene: SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1".
^ Underhill SM, Wheeler DS, Li M, Watts SD, Ingram SL, Amara SG (July 2014). "Amphetamine modulates excitatory neurotransmission through endocytosis of the glutamate transporter EAAT3 in dopamine neurons". Neuron. 83 (2): 404–416. doi:10.1016/j.neuron.2014.05.043. PMC 4159050. PMID 25033183. In general, EAATs 1 and 2 are found predominantly in astrocytes, EAAT3 in neurons, EAAT4 in Purkinje cells, and EAAT5 expression is restricted to the retina (Danbolt, 2001). The dependence of EAAT3 internalization on the DAT also suggests that the two transporters might be internalized together. We found that EAAT3 and DAT are expressed in the same cells, as well as in axons and dendrites. However, the subcellular co-localization of the two neurotransmitter transporters remains to be established definitively by high resolution electron microscopy.
^ Stewart SE, Mayerfeld C, Arnold PD, Crane JR, O'Dushlaine C, Fagerness JA, et al. (June 2013). "Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1" (PDF). American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 162B (4): 367–79. doi:10.1002/ajmg.b.32137. hdl:2027.42/98412. PMID 23606572. S2CID 20929721.
^ Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD (March 2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature. 410 (6824): 84–8. Bibcode:2001Natur.410...84L. doi:10.1038/35065084. PMID 11242046. S2CID 4622513.

추가 읽기

Nieoullon A, Canolle B, Masmejean F, Guillet B, Pisano P, Lortet S (August 2006). "The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?". Journal of Neurochemistry. 98 (4): 1007–18. doi:10.1111/j.1471-4159.2006.03978.x. PMID 16800850. S2CID 22532007.
Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG (September 1994). "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex". The Journal of Neuroscience. 14 (9): 5559–69. doi:10.1523/jneurosci.14-09-05559.1994. PMC 6577102. PMID 7521911.
Shashidharan P, Huntley GW, Meyer T, Morrison JH, Plaitakis A (October 1994). "Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain". Brain Research. 662 (1–2): 245–50. doi:10.1016/0006-8993(94)90819-2. PMID 7859077. S2CID 35811464.
Kanai Y, Stelzner M, Nussberger S, Khawaja S, Hebert SC, Smith CP, Hediger MA (August 1994). "The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport". The Journal of Biological Chemistry. 269 (32): 20599–606. doi:10.1016/S0021-9258(17)32035-5. PMID 7914198.
Zerangue N, Kavanaugh MP (June 1996). "Interaction of L-cysteine with a human excitatory amino acid transporter". The Journal of Physiology. 493 (Pt 2): 419–23. doi:10.1113/jphysiol.1996.sp021393. PMC 1158927. PMID 8782106.
Bar-Peled O, Ben-Hur H, Biegon A, Groner Y, Dewhurst S, Furuta A, Rothstein JD (December 1997). "Distribution of glutamate transporter subtypes during human brain development". Journal of Neurochemistry. 69 (6): 2571–80. doi:10.1046/j.1471-4159.1997.69062571.x. PMID 9375691. S2CID 34227788.
He Y, Janssen WG, Rothstein JD, Morrison JH (March 2000). "Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus". The Journal of Comparative Neurology. 418 (3): 255–69. doi:10.1002/(SICI)1096-9861(20000313)418:3<255::AID-CNE2>3.0.CO;2-6. PMID 10701825.
Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD (March 2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature. 410 (6824): 84–8. Bibcode:2001Natur.410...84L. doi:10.1038/35065084. PMID 11242046. S2CID 4622513.
Veenstra-VanderWeele J, Kim SJ, Gonen D, Hanna GL, Leventhal BL, Cook EH (March 2001). "Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder". Molecular Psychiatry. 6 (2): 160–7. doi:10.1038/sj.mp.4000806. PMID 11317217.
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이 기사는 공공영역에 있는 미국 국립 의학 도서관의 텍스트를 통합하고 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000106688 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG000024935 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8020993-5] Smith CP, Weremowicz S, Kanai Y, Stelzner M, Morton CC, Hediger MA (March 1994). "Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders". Genomics. 20 (2): 335–6. doi:10.1006/geno.1994.1183. PMID 8020993.

[entrez-6] "Entrez Gene: SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1".

[EAAT3-7] Underhill SM, Wheeler DS, Li M, Watts SD, Ingram SL, Amara SG (July 2014). "Amphetamine modulates excitatory neurotransmission through endocytosis of the glutamate transporter EAAT3 in dopamine neurons". Neuron. 83 (2): 404–416. doi:10.1016/j.neuron.2014.05.043. PMC 4159050. PMID 25033183. In general, EAATs 1 and 2 are found predominantly in astrocytes, EAAT3 in neurons, EAAT4 in Purkinje cells, and EAAT5 expression is restricted to the retina (Danbolt, 2001). The dependence of EAAT3 internalization on the DAT also suggests that the two transporters might be internalized together. We found that EAAT3 and DAT are expressed in the same cells, as well as in axons and dendrites. However, the subcellular co-localization of the two neurotransmitter transporters remains to be established definitively by high resolution electron microscopy.

[8] Stewart SE, Mayerfeld C, Arnold PD, Crane JR, O'Dushlaine C, Fagerness JA, et al. (June 2013). "Meta-analysis of association between obsessive-compulsive disorder and the 3' region of neuronal glutamate transporter gene SLC1A1" (PDF). American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 162B (4): 367–79. doi:10.1002/ajmg.b.32137. hdl:2027.42/98412. PMID 23606572. S2CID 20929721.

[pmid11242046-9] Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD (March 2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature. 410 (6824): 84–8. Bibcode:2001Natur.410...84L. doi:10.1038/35065084. PMID 11242046. S2CID 4622513.

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흥분성 아미노산 트랜스포터 3

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조직 분포

함수

상호작용

참고 항목

참조

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