호모사피엔스 종의 단백질 코딩 유전자
Caspase-10 은 인간에서 CASP10 유전자 에 의해 암호화된 효소 다.[3]
이 유전자는 시스테인-아스파르트산프로테아제(카스파제) 계열의 단백질을 인코딩한다. 캐스퍼스의 순차적 활성화는 세포사멸의 실행단계에서 중심적인 역할을 한다. 캐스파아제는 활성 효소를 형성하기 위해 조광하는 크고 작은 두 개의 서브유닛을 생성하기 위해 보존된 아스파르트 잔류물에서 단백질 분해 처리를 거치는 비활성 프로엔자임으로 존재한다. 이 단백질은 3번과 7번 가스를 분해하여 활성화하며, 단백질 자체는 8번 가스로 처리된다. 이 유전자의 돌연변이는 타입 II 자가면역 림프구 수축 증후군에서 보이는 세포사멸 결함과 관련이 있다. 다른 ISO 양식을 인코딩하는 세 가지 대안으로 분할된 대본 변형이 이 유전자에 대해 설명되었다.[4]
상호작용 Caspase 10은 FADD ,[5] [6] [7] [8] CFLA ,[7] [9] [10] Caspase 8 , [5] [9] [11] [12] Fas 수용체 ,[5] [6] [13] RYBP ,[14] TNFRSF1A [5] [6] TNFRSF10B 와 상호작용 하는 것으로 나타났다.[5] [13]
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