Transfer of p14ARF gene in drug-resistant human breast cancer MCF-7/Adr cells inhibits proliferation and reduces doxorubicin resistance. (Q54039211)

24 May 2018

title

Transfer of p14ARF gene in drug-resistant human breast cancer MCF-7/Adr cells inhibits proliferation and reduces doxorubicin resistance. (English)

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24 May 2018

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Guo-Chang F

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24 May 2018

Chu-Tse W

series ordinal

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24 May 2018

language of work or name

English

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publication date

1 October 2000

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24 May 2018

published in

Cancer Letters

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24 May 2018

volume

158

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24 May 2018

issue

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24 May 2018

page(s)

203-210

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24 May 2018

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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The INK4a/ARF tumor suppressor: one gene--two products--two pathways

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Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

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Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

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E1A signaling to p53 involves the p19(ARF) tumor suppressor

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Tumor surveillance via the ARF-p53 pathway.

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

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7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

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p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts.

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Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes

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Development and characterisation of novel human multidrug resistant mammary carcinoma linesin vitro andin vivo

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Lack of competition of substrates for P-glycoprotein in MCF-7 breast cancer cells overexpressing MDR1

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7 January 2021

Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells

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Predicting response to cancer chemotherapy: the role of p53.

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7 January 2021

p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents

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7 January 2021

10.1016/S0304-3835(00)00524-3

Identifiers

DOI

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24 May 2018

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24 May 2018