Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal (Q34785457)

4 August 2017

title

Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal (English)

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4 August 2017

author name string

Stephanie C Ems-McClung

series ordinal

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4 August 2017

Yixian Zheng

series ordinal

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4 August 2017

Claire E Walczak

series ordinal

1 reference

4 August 2017

publication date

17 September 2003

1 reference

Molecular Biology of the Cell

4 August 2017

published in

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

46-57

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Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity.

4 August 2017

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Importin beta is a mitotic target of the small GTPase Ran in spindle assembly

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Beyond nuclear transport. Ran-GTP as a determinant of spindle assembly

7 July 2018

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Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation

7 July 2018

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Autoinhibition by an internal nuclear localization signal revealed by the crystal structure of mammalian importin alpha

7 July 2018

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Identification of microtubule binding sites in the Ncd tail domain

7 July 2018

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The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro

7 July 2018

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Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha

7 July 2018

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7 July 2018

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Microtubule Interaction Site of the Kinesin Motor

7 July 2018

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XCTK2: a kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Opposing motor activities are required for the organization of the mammalian mitotic spindle pole

7 July 2018

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Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts

7 July 2018

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Analysis of a nuclear localization signal of simian virus 40 major capsid protein Vp1.

7 July 2018

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A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

C-terminal kinesin motor KIFC1 participates in acrosome biogenesis and vesicle transport

7 July 2018

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Identification of Ncd tail domain-binding sites on the tubulin dimer

26 October 2018

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The auto-inhibitory function of importin alpha is essential in vivo.

26 October 2018

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Nuclear translocation of plk1 mediated by its bipartite nuclear localization signal

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

Ran binds to chromatin by two distinct mechanisms.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

Ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

The GTPase Ran regulates chromosome positioning and nuclear envelope assembly in vivo.

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

Role of importin-beta in the control of nuclear envelope assembly by Ran.

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly

26 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

Efficiency of importin alpha/beta-mediated nuclear localization sequence recognition and nuclear import. Differential role of NTF2.

26 October 2018

1 reference

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The ran GTPase regulates mitotic spindle assembly.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

Kin I kinesins are microtubule-destabilizing enzymes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

Structural and functional domains of the Drosophila ncd microtubule motor protein.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=307526

Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1

26 October 2018

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12 December 2020

Mutations within the Ran/TC4 GTPase. Effects on regulatory factor interactions and subcellular localization

1 reference

12 December 2020

Kinetic characterization of the human retinoblastoma protein bipartite nuclear localization sequence (NLS) in vivo and in vitro. A comparison with the SV40 large T-antigen NLS

1 reference

12 December 2020

Equilibrium binding studies of non-claret disjunctional protein (Ncd) reveal cooperative interactions between the motor domains

1 reference

12 December 2020

Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran

1 reference

12 December 2020

Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran

1 reference

12 December 2020

Function of a minus-end-directed kinesin-like motor protein in mammalian cells

1 reference

12 December 2020

Quantitative analysis of nuclear localization signal (NLS)-importin alpha interaction through fluorescence depolarization. Evidence for auto-inhibitory regulation of NLS binding.

1 reference

12 December 2020

Ran hits the ground running

1 reference

12 December 2020

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

1 reference

12 December 2020

A novel mechanism for activation of the protein kinase Aurora A

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12 December 2020

Identifiers

DOI

10.1091/MBC.E03-07-0454

1 reference

4 August 2017

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4 August 2017

1 reference