Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). (Q34010341)

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6 December 2019

title

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) (English)

1 reference

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amyotrophic lateral sclerosis

6 December 2019

main subject

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1 reference

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6 December 2019

David S Howland

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6 December 2019

Jian Liu

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6 December 2019

Yijin She

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6 December 2019

Beth Goad

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6 December 2019

Nicholas J Maragakis

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6 December 2019

Benjamin Kim

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6 December 2019

Jamie Erickson

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6 December 2019

John Kulik

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6 December 2019

Lisa DeVito

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6 December 2019

George Psaltis

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6 December 2019

Louis J DeGennaro

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6 December 2019

Jeffrey D Rothstein

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6 December 2019

language of work or name

English

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publication date

29 January 2002

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Proceedings of the National Academy of Sciences of the United States of America

6 December 2019

published in

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volume

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issue

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6 December 2019

page(s)

1604-1609

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Transgenic mouse model for familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation

6 December 2019

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis.

5 July 2018

1 reference

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

5 July 2018

1 reference

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Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

5 July 2018

1 reference

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Fimbria-fornix transections selectively down-regulate subtypes of glutamate transporter and glutamate receptor proteins in septum and hippocampus.

5 July 2018

1 reference

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Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Localization of neuronal and glial glutamate transporters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122237

Superoxide dismutase and neurofilament transgenic models of amyotrophic lateral sclerosis.

29 October 2018

1 reference

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Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: neurochemical correlates of selective vulnerability

29 October 2018

1 reference

12 December 2020

A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis

1 reference

12 December 2020

Inhibition of ICE slows ALS in mice

1 reference

12 December 2020

Presence of Cu/Zn superoxide dismutase (SOD) immunoreactivity in neuronal hyaline inclusions in spinal cords from mice carrying a transgene for Gly93Ala mutant human Cu/Zn SOD

1 reference

12 December 2020

Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

1 reference

12 December 2020

The genetic and molecular mechanisms of motor neuron disease

1 reference

12 December 2020

Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration

1 reference

12 December 2020

ALS-linked Cu/Zn-SOD mutation impairs cerebral synaptic glucose and glutamate transport and exacerbates ischemic brain injury

1 reference

12 December 2020

Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease

1 reference

12 December 2020

Familial motor neuron disease. Evidence for at least three different types

1 reference

12 December 2020

Molecular biology. Enhancers, chromosome position effects, and transgenic mice

1 reference

12 December 2020

Neurofibrillary axonal swellings and amyotrophic lateral sclerosis

1 reference

12 December 2020

ALS, SOD and peroxynitrite

1 reference

12 December 2020

[3H]d-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study

1 reference

12 December 2020

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1 reference

12 December 2020

Regional deafferentation down-regulates subtypes of glutamate transporter proteins

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.032539299

1 reference

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6 December 2019

0 references

1 reference

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6 December 2019

PubMed publication ID

11818550

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11818550%20AND%20SRC:MED&resulttype=core&format=json