Polo like kinase 1 (Q21131841)

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mammalian protein found in Homo sapiens
  • cell cycle regulated protein kinase
  • PLK1
  • serine/threonine-protein kinase PLK1
  • serine/threonine-protein kinase 13
  • polo (Drosophia)-like kinase
  • STPK13
  • Polo-like kinase 1
  • PLK-1
edit
Language Label Description Also known as
English
Polo like kinase 1
mammalian protein found in Homo sapiens
  • cell cycle regulated protein kinase
  • PLK1
  • serine/threonine-protein kinase PLK1
  • serine/threonine-protein kinase 13
  • polo (Drosophia)-like kinase
  • STPK13
  • Polo-like kinase 1
  • PLK-1

Statements

molecular function
protein binding
determination method or standard
IPI
57 references
retrieved
8 April 2019
stated in
Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase 1 phosphorylation of p150 Glued facilitates nuclear envelope breakdown during prophase
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Plk1-mediated phosphorylation of Topors regulates p53 stability
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tumor suppressor CYLD regulates entry into mitosis
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of right open reading frame 2 (Rio2) protein kinase by polo-like kinase 1 regulates mitotic progression
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Active cyclin B1-Cdk1 first appears on centrosomes in prophase
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ubiquitylation-dependent localization of PLK1 in mitosis
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic identification of Hsp70 as a new Plk1 substrate in arsenic trioxide-induced mitotically arrested cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Final stages of cytokinesis and midbody ring formation are controlled by BRUCE
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation by polo-like kinase 1 induces the tumor-suppressing activity of FADD
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of chromatin-associated Plk1 and Mcm7
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase 1 regulates mitotic arrest after UV irradiation through dephosphorylation of p53 and inducing p53 degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Systematic analysis of human protein complexes identifies chromosome segregation proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of a novel Wnt5a-CK1É›-Dvl2-Plk1-mediated primary cilia disassembly pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
retrieved
8 April 2019
stated in
RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IPI
protein serine/threonine kinase activity
determination method or standard
IEA
IDA
EXP
IMP
TAS
17 references
retrieved
7 November 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
TAS
retrieved
7 November 2018
stated in
Ubiquitylation-dependent localization of PLK1 in mitosis
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IMP
retrieved
7 November 2018
stated in
Plk1-mediated phosphorylation of Topors regulates p53 stability
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IMP
retrieved
7 November 2018
stated in
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IMP
retrieved
7 November 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IEA
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IEA
retrieved
7 November 2018
stated in
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Active cyclin B1-Cdk1 first appears on centrosomes in prophase
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
EXP
retrieved
7 November 2018
stated in
Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
EXP
protein kinase activity
determination method or standard
IDA
IEA
IMP
NAS
6 references
retrieved
1 January 2018
stated in
Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
NAS
retrieved
1 January 2018
stated in
Structure of the catalytic domain of human polo-like kinase 1
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IMP
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IEA
retrieved
1 January 2018
stated in
Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
1 January 2018
stated in
Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
1 January 2018
stated in
RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
protein serine/threonine kinase activity
determination method or standard
EXP
IBA
IDA
IEA
IMP
TAS
19 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
TAS
retrieved
8 April 2019
stated in
Ubiquitylation-dependent localization of PLK1 in mitosis
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IMP
retrieved
8 April 2019
stated in
Plk1-mediated phosphorylation of Topors regulates p53 stability
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IMP
retrieved
8 April 2019
stated in
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IEA
retrieved
8 April 2019
stated in
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Active cyclin B1-Cdk1 first appears on centrosomes in prophase
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Inhibitory role of Plk1 in the regulation of p73-dependent apoptosis through physical interaction and phosphorylation
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IBA
retrieved
8 April 2019
stated in
Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
EXP
retrieved
8 April 2019
stated in
Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
EXP
cell component
centrosome
determination method or standard
IDA
9 references
retrieved
7 November 2018
stated in
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Ubiquitylation-dependent localization of PLK1 in mitosis
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Bod1 regulates protein phosphatase 2A at mitotic kinetochores
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Active cyclin B1-Cdk1 first appears on centrosomes in prophase
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
GOA
curator
LifeDB
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
7 November 2018
stated in
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P53350&geneProductId=UniProtKB:P53350
determination method or standard
IDA
kinetochore
determination method or standard
IDA
IEA
9 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IEA
retrieved
8 April 2019
stated in
Bod1 regulates protein phosphatase 2A at mitotic kinetochores
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Chromosome congression is promoted by CENP-Q- and CENP-E-dependent pathways
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Ubiquitylation-dependent localization of PLK1 in mitosis
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
centrosome
determination method or standard
IBA
IDA
10 references
retrieved
8 April 2019
stated in
Bod1 regulates protein phosphatase 2A at mitotic kinetochores
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Active cyclin B1-Cdk1 first appears on centrosomes in prophase
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Ubiquitylation-dependent localization of PLK1 in mitosis
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
GOA
curator
LifeDB
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IBA
biological process
protein phosphorylation
determination method or standard
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
Structure of the catalytic domain of human polo-like kinase 1
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IEA
retrieved
8 April 2019
stated in
Polo-like kinase 1 phosphorylation of p150 Glued facilitates nuclear envelope breakdown during prophase
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression
GOA
curator
UniProt
UniProt protein ID
P53350
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA
retrieved
8 April 2019
stated in
The centrosomal kinase Plk1 localizes to the transition zone of primary cilia and induces phosphorylation of nephrocystin-1
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53350
determination method or standard
IDA

Identifiers

Freebase ID
/m/03cv0_8
0 references
Microsoft Academic ID
146276462
0 references
2909307338
0 references
PDB structure ID
 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q21131841&oldid=2023016184"