Dicer 1, ribonuclease III (Q21111297)

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mammalian protein found in Homo sapiens
  • endoribonuclease Dicer
  • dicer 1, ribonuclease type III
  • dicer 1, double-stranded RNA-specific endoribonuclease
  • helicase with RNAse motif
  • DICER1
  • Dicer1, Dcr-1 homolog
  • helicase MOI
edit
Language Label Description Also known as
English
Dicer 1, ribonuclease III
mammalian protein found in Homo sapiens
  • endoribonuclease Dicer
  • dicer 1, ribonuclease type III
  • dicer 1, double-stranded RNA-specific endoribonuclease
  • helicase with RNAse motif
  • DICER1
  • Dicer1, Dcr-1 homolog
  • helicase MOI

Statements

molecular function
protein binding
determination method or standard
IPI
25 references
retrieved
8 April 2019
stated in
Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition
GOA
curator
UniProt
UniProt protein ID
Q9UPY3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA
GOA
curator
UniProt
UniProt protein ID
Q9UPY3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
MicroRNA silencing through RISC recruitment of eIF6
GOA
curator
UniProt
UniProt protein ID
Q9UPY3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
RNA helicase A interacts with RISC in human cells and functions in RISC loading
GOA
curator
UniProt
UniProt protein ID
Q9UPY3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
GOA
curator
UniProt
UniProt protein ID
Q9UPY3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
The role of PACT in the RNA silencing pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
TWEAK Negatively Regulates Human Dicer.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction of human T‐cell lymphotropic virus type I Rex protein with Dicer suppresses RNAi silencing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference-mediated silencing in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nuclear pore complex protein mediated nuclear localization of dicer protein in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural insights into RNA processing by the human RISC-loading complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
retrieved
8 April 2019
stated in
HCV core protein interacts with Dicer to antagonize RNA silencing
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IPI
ribonuclease III activity
determination method or standard
IEA
EXP
IDA
7 references
retrieved
21 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UPY3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
determination method or standard
IEA
retrieved
21 June 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
determination method or standard
IEA
retrieved
21 June 2018
stated in
Dicer recognizes the 5' end of RNA for efficient and accurate processing
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
21 June 2018
stated in
Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
determination method or standard
EXP
retrieved
21 June 2018
stated in
Role for a bidentate ribonuclease in the initiation step of RNA interference
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
determination method or standard
EXP
retrieved
21 June 2018
stated in
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
determination method or standard
EXP
retrieved
21 June 2018
stated in
Ribonuclease activity and RNA binding of recombinant human Dicer
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
determination method or standard
EXP
ribonuclease III activity
determination method or standard
EXP
IBA
IDA
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q9UPY3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IEA
retrieved
8 April 2019
stated in
Dicer recognizes the 5' end of RNA for efficient and accurate processing
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IBA
retrieved
8 April 2019
stated in
Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
EXP
retrieved
8 April 2019
stated in
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
EXP
retrieved
8 April 2019
stated in
Role for a bidentate ribonuclease in the initiation step of RNA interference
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
EXP
retrieved
8 April 2019
stated in
Ribonuclease activity and RNA binding of recombinant human Dicer
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
EXP
cell component
RISC-loading complex
determination method or standard
IDA
6 references
retrieved
8 April 2019
stated in
RNA helicase A interacts with RISC in human cells and functions in RISC loading
GOA
curator
UniProt
UniProt protein ID
Q9UPY3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
8 April 2019
stated in
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
GOA
curator
UniProt
UniProt protein ID
Q9UPY3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
8 April 2019
stated in
Structural insights into RNA processing by the human RISC-loading complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
8 April 2019
stated in
A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
8 April 2019
stated in
In vitro reconstitution of the human RISC-loading complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
8 April 2019
stated in
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
biological process
pre-miRNA processing
determination method or standard
IDA
5 references
retrieved
21 June 2018
stated in
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
GOA
curator
UniProt
UniProt protein ID
Q9UPY3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
21 June 2018
stated in
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
21 June 2018
stated in
A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
21 June 2018
stated in
In vitro reconstitution of the human RISC-loading complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
21 June 2018
stated in
Structure of precursor microRNA's terminal loop regulates human Dicer's dicing activity by switching DExH/D domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPY3&geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
pre-miRNA processing
determination method or standard
IBA
IDA
6 references
retrieved
8 April 2019
stated in
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
GOA
curator
UniProt
UniProt protein ID
Q9UPY3
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
8 April 2019
stated in
Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
8 April 2019
stated in
A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
8 April 2019
stated in
In vitro reconstitution of the human RISC-loading complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
8 April 2019
stated in
Structure of precursor microRNA's terminal loop regulates human Dicer's dicing activity by switching DExH/D domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPY3
determination method or standard
IBA

Identifiers

UniProt protein ID
Q9UPY3
0 references
Ensembl protein ID
ENSP00000343745
0 references
ENSP00000376783
0 references
ENSP00000435681
0 references
ENSP00000437256
0 references
ENSP00000444719
0 references
ENSP00000451041
0 references
ENSP00000433060
0 references
ENSP00000433926
0 references
ENSP00000452556
0 references
Freebase ID
/m/02tcsv
0 references
 
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