Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1 (Q28585290)

31 January 2017

title

Role of intrinsic DNA binding specificity in defining target genes of the mammalian transcription factor PDX1 (English)

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Pancreatic and duodenal homeobox 1

31 January 2017

main subject

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GOA release 2020-03-11

Arthur Liberzon

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31 January 2017

Gabriela Ridner

series ordinal

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31 January 2017

Michael D. Walker

series ordinal

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31 January 2017

language of work or name

English

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publication date

1 January 2004

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31 January 2017

published in

Nucleic Acids Research

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31 January 2017

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31 January 2017

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31 January 2017

page(s)

54–64

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Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

31 January 2017

cites work

1 reference

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17 March 2017

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Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia

17 March 2017

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Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

17 March 2017

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17 March 2017

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The pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomain

17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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17 March 2017

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29 September 2017

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Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

29 September 2017

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Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function.

29 September 2017

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Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression

29 September 2017

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Regulation of insulin gene transcription

29 September 2017

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Transcription factor BETA2 acts cooperatively with E2A and PDX1 to activate the insulin gene promoter

29 September 2017

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An endocrine-exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2).

29 September 2017

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beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes

29 September 2017

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Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells

29 September 2017

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Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor

29 September 2017

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A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of HOX protein in the heterodimer

29 September 2017

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29 September 2017

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Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain proteins

29 September 2017

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29 September 2017

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29 September 2017

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The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain.

29 September 2017

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Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells

29 September 2017

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A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer

29 September 2017

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DNA binding specificity of homeodomains

29 September 2017

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DNA-binding specificity of the fushi tarazu homeodomain

29 September 2017

1 reference

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Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila

29 September 2017

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Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells

29 September 2017

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Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene

29 September 2017

1 reference

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Differential DNA sequence recognition is a determinant of specificity in homeotic gene action.

29 September 2017

1 reference

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DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells

29 September 2017

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Regulation of segmentation and segmental identity by Drosophila homeoproteins: the role of DNA binding in functional activity and specificity.

29 September 2017

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Homeodomain-type DNA recognition

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

The insulin gene promoter. A simplified nomenclature

3 June 2018

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Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic alpha- and beta-cells

3 June 2018

1 reference

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Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2.

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373268

Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

27 November 2018

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Hox proteins meet more partners

27 November 2018

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12 December 2020

Structural basis of Hox specificity

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12 December 2020

Attenuation of FGF signalling in mouse β-cells leads to diabetes

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12 December 2020

Structural aspects of homeodomain interactions with DNA

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The role of hepatic nuclear factor 1 alpha and PDX-1 in transcriptional regulation of the pdx-1 gene

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12 December 2020

Activation of the insulin gene promoter through a direct effect of hepatocyte nuclear factor 4 alpha

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Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

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Identifiers

1 reference

31 January 2017

0 references

1 reference