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Review: some basic chemical

words and concepts


Polar Covalent Bonds and Electronegativity:

 Covalent bonds (between two different atoms) in which the


sharing of the electron pair is unequal are called polar covalent
bonds (electrons spending more time around the more
nonmetallic atom).
 In such a polar covalent bonds there is a charge separation with
one atom being slightly more positive and the other more
negative, i.e., the bond will produce a dipole moment.
 The ability of an atom to attract electrons in the presence of
another atom is a measurable property called electronegativity.
+
H H H O
Weak chemical forces
Covalent bonds hold atoms together so that molecules are formed.
In contrast, weak chemical forces or noncovalent bonds are
intramolecular or intermolecular attractions between atoms.

• Hydrogen bonds
• Van der Waals forces
• Ionic interactions
• Hydrophobic
interactions
None of these forces are strong enough to bind free atoms together.
(typically range from 4 to 30 kJ/mol)
Hydrogen bonds (H bonds)
Hydrogen bonds Form between a hydrogen and a second electronegative
atom
Strength: 12~30 kJ/mol ; Distance: 0.3 nm

H bonds are cylindrically symmetrical and tend to be highly directional,


forming straight bonds between donor, hydrogen, and acceptor atoms.
Van der Waals forces

Van der Waals forces are the result of induced electrical interactions
between closely approaching atoms or molecules as their negatively
charged electron clouds fluctuate instantaneously in time.

Strength: 0.4~4.0 kJ/mol ; Distance: 0.3~0.6 nm

Strength depends on the relative size of the atoms or molecules and the
distance between two molecules: The greater the area, the stronger the
interaction.
The sum of many such interactions within a macromolecule or between
molecules can be substantial (accumulated).
Ionic interactions

Ionic interactions are the result of attractive forces


between a positive charged group and a negative
charged group (intramolecular or intermolecular).
Strength: 20 kJ/mol ; Distance: 0.25 nm
Strength also depends on the relative polarity of the
interacting charged species.
_
NH3+ OOC
Because the electrical charge is radially distributed, these
interactions may lack the directionality of H bonds or the
precise fit of van der Waals interactions.
Hydrophobic interactions

 Hydrophobic interactions result from the strong tendency of


water to exclude nonpolar groups or molecules

 Water molecules “exclude” hydrophobic molecules from aqueous


solution and drive the tendency of nonpolar molecules to cluster
together

 The formation of oil droplets in the water is an approximation of


this phenomenon

 These tendencies have important consequences in the creation


and maintenance of the macromolecular structures and
supramolecular assemblies of living cells

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