Deep Venous Thrombosis & Pulmonary Embolism
Deep Venous Thrombosis & Pulmonary Embolism
Deep Venous Thrombosis & Pulmonary Embolism
Thrombosis
The subject: Internal
Medicine I
Subject professor: Dr. Guram
Rtskhiladze
BY: Juma Awar
UG: 1802018
Introduction
Deep vein thrombosis (DVT) occurs
when a blood clot (thrombus) forms in
one or more of the deep veins in the
body, usually in the legs, although it
rarely can affect the arms and the veins
inside the abdomen and the brain.
Virchow’s triad
1. Blood flow stasis
2. Blood
hypercoagulability
3. Endothelial damage
Blood flow stasis
1. Atrial fibrillation
2. Long travel in a plane or a car
3. Post-operative
4. Paralysis
5. Varicose veins
6. Compression due to pregnancy, may-Thurner syndrome, obesity
Blood hypercoagulability
1. Trauma or surgery
2. Smoking
3. Obesity
4. Venipuncture
5. Chemical irritation
6. Indwelling catheters
Pathophysiology
Recruitment Release of
Virchow’s triad
of platelets microparticles
Formation of
Platelet neutrophil Stimulation of
aggregation extracellular neutrophils
traps
• Warfarin
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