Antelmintik 1
Antelmintik 1
Antelmintik 1
microtubule synthesis
Poorly absorbed (PO).
Active against nematodes (drugs of choice).
Toxicity: gastrointestinal irritation, allergic
reaction, embryotoxicity
Mechanism unknown
Clinical use
◦ Filariasis (DOC)
◦ Alternative for onchocerciasis
Toxicity: fever,rashes,ocular damage, joint
and muscle pain,lymphangitis.
Mechanisms: intensifies GABA-mediated
neurotransmission in nematodes
Clinical use: Active on most common
intestinal worms (except tapeworms), most
mites, and some lice. Strongyloides
stercoralis, onchocerciasis (DOC). And
alternative agent in filariasis
Toxicity: fever, headache, dizziness, rashes,
pruritus, tachycardia, hypotensi, pain in
joints, muscle and lymph glands (Mazzotti
reactions)
Mechanisms: stimulate nicotinic receptor
present at Neuromuscular junction of
nematodes. Contraction of muscle occurs
depolarization-induced paralysis
Clinical use: drugs of choice for infection due
ti hookworm, pinworm and roundworm
Tocixity: Nausea, vomiting, deadache,
weaknes and neurotoxic effects ...
1. Praziquantel
2. Bithionol
3. Metrifonate
4. Oxamniquine
1. Niclosamide
2. Praziquantel
3. Albendazole
4. Mebendazole
Mechanism: increases membrane
permeaility to calcium
Clinical use: trematodes and cestodes.
Drugs of choice in schistomiasis,
clonorchiasis, paragonimiasis and in
the treatment of cysticercosis
Toxicity: Headache,dizziness,malaese,
fever, skin rash and G I Tract iritation.
Contraindicated in ocular cysticercosis.
Mechanism : unknown
Clinical use: The drugs of choice
for treatment of fascioliasis and
an alternative drugs in
paragonimiasis
Toxicity: nausea, vomiting,
diarrhea, abdominal cremps,
headache,dizziness,malaese
Mechanism: unccoupling oxidative
phosphorilasi or by activating ATPase
Clinical : tapeworm infection not for
cysticercosis. Active against T. saginata,
D. latum, H. Nana, D. caninum, T. solium
(risk of autoinfection due to
disintegration; prefer praziquantel).
Toxicity: headache, GI tract. Fever rash
by antigen of parasite.
A n t h e lm in t ic D r u g s
D r u g s a c t iv e D r u g s a c t iv e D r u g s a c t iv e
a g a in s t a g a in s t a g a in s t
N e m a to d e s T re m a to d e s C e s to d e s
A lb e n d a z o le P r a z iq u a n t e l N ic lo s a m id e
D ie t h y lc a r b a m a z in e B it h io n o l P r a z iq u a n t e l
I v e r m e c t in M e t r ifo n a t e A lb e n d a z o le
M e b e n d a z o le O x a m n iq u in e M e b e n d a z o le