Dissolution Teaching Module
Dissolution Teaching Module
Dissolution Teaching Module
Teaching Module
Bo Hu
Chemical Engineering @ UPRM
Outline
• Introduction
• Dissolution procedure
• IVIVC
• Dissolution Analysis
• Applications
Activity of GI-tract
Dosage Forms
• Storage
• Separation – depending on technological type
• Transport
• Processing
–disintegration
–dissolution
–decomposition
• Absorption of drugs
–many xenobiotics are absorbed by passive diffusion (lipophilicity,
molecular weight)
• Resecretion of drugs to GI-Tract
• Drug disintegration --- first order process
• Drug dissolution ---proportional to the
concentration difference of the drug
between the particle surface and the bulk
solution
Definition
1 n
0.5
f 2 50 log 1 Rt Tt 100
2
n t 1
Extended application
• Ordinary tablets and capsules
• Extended –release
• Delayed-release
• Transdermal
• Multivitamin
• Mineral
• Class Monographs for non-prescription
drug combinations
References