Chapter7 B and T Cell Activation (1) Immunology
Chapter7 B and T Cell Activation (1) Immunology
Chapter7 B and T Cell Activation (1) Immunology
of T and B lymphocyte
Fairus Hassim, PhD
PPSA, UMT
09-6683701
What will you learn?
CD4+ T cells activation
Interaction between antigen presenting cells (APCs) and CD4 + T cells
Function of costimulatory pairs
CD4+ T subsetting by cytokine
CD4+ T cell memory
CD8+ T cell function
Elimination of targeted cell by cytotoxic T cells
Superantigen
Activation of B cells and its function
T and B cooperation
Carrier effect
T-independent immune response
T and B cell activation
Activation and Maturation of B cells
Activation and Maturation of B cells
Another mode of B cell activation and
maturation
How B and T cells being activated at
molecular level?
Carrier effect
( " C " = c a r r ie r d e te r m in a n t ,
" H " = h a p te n d e te r m in a n t) D iffe r e n tia tio n
to A F C
A N T I G E N P R E S E N T A T I O N B Y M A C R O P H A G E T O TH (V ) - C E L L
A n t ig e n p h a g o c y t o s e d b y m a c r o p h a g e A g - p r e s e n ta tio n
( A g / C la s s I I +
H
C H
H C H
C H
C
c o s ti m u l a tio n )
H
C H
H
H
A n tig e n
" p r o c e s s in g " A g - p r e s e n ta tio n : H
C H
C H ( A g / C la s s II +
H
c o s tim u la tio n ) H
APC 7 7 28
II
C 28
A n tig e n
CD
A n tig e n " p r o c e s s in g "
C H 4 C
T H (M ) - C E L L
H
C H
T H ( V )- C E L L b o u n d b y Ig II
H C
H
H
r e c e p to r s B (M ) -C E L L C D 4
A n tig e n
b o u n d b y Ig B (V ) -C E L L T - c e ll h e l p :
r e c e p to r s IL -4
D i f f e r e n t i a ti o n
( " C " = c a r r ie r d e t e r m in a n t, to A F C T - c e ll h e lp :
D i f f e r e n t i a ti o n
" H " = h a p te n d e te r m in a n t )
to A F C IL -4
A N T I G E N P R E S E N T A T I O N B Y M A C R O P H A G E T O TH (V ) - C E L L
A N T I G E N P R E S E N T A T I O N B Y B ( M ) - C E L L T O TH ( M ) - C E L L
A g - p r e s e n ta tio n
C H
( A g / C la s s I I +
H
C H
c o s tim u l a tio n )
C E L L IN T E R A C T IO N S IN H U M O R A L IM M U N IT Y
H
C H
7 28
References
http://www.nature.com/nri/journal/v12/n1/fig_tab/nri3128_F1.html
Frauwirth, Kenneth A., and Craig B. Thompson. Activation and Inhibition of Lymphocytes by
Costimulation. The Journal of Clinical Investigation 109, no. 3 (February 1, 2002): 29599.
doi:10.1172/JCI14941.
Restifo, Nicholas P. Big Bang Theory of Stem-like T Cells Confirmed. Blood 124, no. 4 (July 24, 2014):
47677. doi:10.1182/blood-2014-06-578989.