Nothing Special   »   [go: up one dir, main page]
Scribd Logo
Upload

Welcome to Scribd!

  • 1K views

    The Role of Wheat Grass Juice in Blood

    Uploaded by

    guddu007
    The document discusses the role of wheat grass juice in reducing blood transfusion requirements for patients with thalassemia intermediate. A pilot study found that drinking wheat grass juice allowed patients to reduce their transfusion needs by 25-29.5% on average and increased the time between transfusions. Wheat grass juice is thought to help trap iron in red blood cells and slow their decay, reducing iron overload from frequent transfusions. It may also have antioxidant effects that benefit patients with thalassemia.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd

    The Role of Wheat Grass Juice in Blood

    Uploaded by

    guddu007
    1K views35 pages
    The document discusses the role of wheat grass juice in reducing blood transfusion requirements for patients with thalassemia intermediate. A pilot study found that drinking wheat grass juice allowed patients to reduce their transfusion needs by 25-29.5% on average and increased the time between transfusions. Wheat grass juice is thought to help trap iron in red blood cells and slow their decay, reducing iron overload from frequent transfusions. It may also have antioxidant effects that benefit patients with thalassemia.

    Original Description:

    important

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The document discusses the role of wheat grass juice in reducing blood transfusion requirements for patients with thalassemia intermediate. A pilot study found that drinking wheat grass juice allowed patients to reduce their transfusion needs by 25-29.5% on average and increased the time between transfusions. Wheat grass juice is thought to help trap iron in red blood cells and slow their decay, reducing iron overload from frequent transfusions. It may also have antioxidant effects that benefit patients with thalassemia.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    1K views35 pages

    The Role of Wheat Grass Juice in Blood

    Uploaded by

    guddu007
    The document discusses the role of wheat grass juice in reducing blood transfusion requirements for patients with thalassemia intermediate. A pilot study found that drinking wheat grass juice allowed patients to reduce their transfusion needs by 25-29.5% on average and increased the time between transfusions. Wheat grass juice is thought to help trap iron in red blood cells and slow their decay, reducing iron overload from frequent transfusions. It may also have antioxidant effects that benefit patients with thalassemia.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 35

    The Role of Wheat Grass Juice in Blood Transfusion

    Requirement of Intermediate Thalassemia

    ARNAB BHATTACHARJEE
    BARRACKPORE RASTRAGURU
    SURENDRANATH COLLEGE
    M.Sc Vth year
    Roll Number: 06G4MMS016
    05/29/08 11:56 PM
    Definition:
     Thalassemia is inherited disorders
    characterized by reduced or absent
    amounts of hemoglobin, the oxygen-
    carrying protein inside the red blood cells

    05/29/08 11:56 PM
    Structure of Haemoglobin

    05/29/08 11:56 PM
    Three Basic Groups of
    Thalassemia Disorder

     Alpha Thalassemia

     Beta Thalassemia

    • HbE Thalassemia

    05/29/08 11:56 PM
    Beta Thalassemia
     It is caused by a change in the gene for
    the beta -globin component of
    hemoglobin.
     It can cause variable anemia that can
    range from moderate to severe.

    05/29/08 11:56 PM
    There are 3 types of Beta
    Thalassemia

     Thalassemia Minor

     Thalassemia Intermediate.

     Thalassemia Major or Cooley's Anemia

    05/29/08 11:56 PM
    GENETICS OF THALLASSEMIA
    α chains ß chains

    Chromosome 16 chromosome 11

    Translation Rate

    α α
    ß
    α α
    ß α
    α

    05/29/08 11:56 PM
    Demographics: Thalassemia
    • Beta Thalassemia trait is seen
    most commonly in people with
    the following ancestry:
    Mediterranean (including North
    African, and particularly Italian
    and Greek), Middle Eastern,
    Indian, African, Chinese, and
    Southeast Asian (including
    Vietnamese, Laotian, Thai,
    Singaporean, Filipino,
    Cambodian, Malaysian,
    Burmese, and Indonesian

    05/29/08 11:56 PM
    PREVALENCE

    05/29/08 11:56 PM
    OUR GLOBAL POSITION

    05/29/08 11:56 PM
    Symptoms of Beta Thalassemia
     It is characterized by severe anemia that
    can begin months after birth.
     Paleness
     Delays in growth and development
     Bone marrow expansion.
     Untreated Beta Thalassemia major can
    lead to child death due to heart failure.

    05/29/08 11:56 PM
    Treatment of Beta Thalassemia
     Regular blood transfusion helps prevent
    severe anemia and allows for more normal
    growth and development.
     There are various medications that target
    the production of red blood cells (i.e.
    erythropoeitin)

    05/29/08 11:56 PM
    Body iron Distribution and
    Storage

    05/29/08 11:56 PM
    Why we need Iron…..
     Enzymes
     Oxygen Transport

    - Haemoglobin (Red Blood cells)


    - Myoglobin (Muscle cells)
    About 70% of body’s Iron is in these
    proteins.

    05/29/08 11:56 PM
    We cope well with Iron
    shortage……
     Iron deficiency is the most common
    deficiency state in the world
    - Blood Loss
    - Diet
     About 1000 mg of Iron in the body is
    stored as ferritin
     Intestinal Iron deficiency Increases iron
    absorption.
    05/29/08 11:56 PM
    …..but poorly with iron excess.
     Iron is excreted by shredding of Intestinal
    cells
     There is no physiologic mechanism to
    excrete excess iron.

    05/29/08 11:56 PM
    Blood transfusions overwhelms the
    Iron balance

    Normal daily iron Each unit of PRBC:


    flux:

    1-2 mg

    05/29/08 11:56 PM
    WHY TOO MUCH IRON IS A BAD
    THING?

    05/29/08 11:56 PM
    05/29/08 11:56 PM
    HOW DO WE KNOW IF THERE IS
    TOO MUCH IRON?
     Serum Ferittin concentration

     Liver Biopsy

     Magnetic Resonance Imaging (MRI)

    05/29/08 11:56 PM
    LESSONS FROM THALLASSEMIA

    05/29/08 11:56 PM
    SUMMARY
    TOO MUCH IRON IS BAD

    WHAT CAN WE DO ABOUT IT?

    IRON CHELATION

    05/29/08 11:56 PM
    WHAT IS CHELATION
    THERAPY?

    05/29/08 11:56 PM
    HOW TO CHELATE?
     CURRENTLY LICENCED
    --- Deferoxamine ( Desferal )
    ---- Deferasirox (ICL 670,Exjade )

     ALTERNATIVE

    -----Deferiprone

    05/29/08 11:56 PM
    SIDE EFFECTS
     Local reactions

     Opthalmologic

     Hearing loss

     Zinc deficiency

     Reports of Kidney Failure, worsening Blood


    counts

    05/29/08 11:56 PM
    New Lease of life

    05/29/08 11:56 PM
    EVEN OUR ANCESTORS KNEW
    ABOUT IT……
    Wheatgrass and other cereal grasses
    have been thoroughly researched and
    reported as a therapeutically effective
    substance since the 1930’s. Traditionally,
    chlorophyll, or its synthetic derivative,
    chlorophyllin, has been implicated as the
    biologically active substance responsible
    for reported healing effects

    05/29/08 11:56 PM
    The Pilot study
     Dr. R. K.Marwaha et al at the Advanced Pediatric Centre,
    Postgraduate Institute of Medical Education and Research,
    Chandigarh, India. Entitled “Wheat grass juice reduces transfusion
    requirement in patients with thalassemia major: a pilot study.”, the
    study was performed between February 2000 and May 2003.
    Sixteen out of 38 (42%) blood transfusion dependent thalassemics
    fulfilled the trial criteria for final analysis.

     To summarise the findings during period of wheatgrass juice


    ingestion:
    • all participants experienced lower blood transfusion requirements
    • 50% had at least 25% reduction in transfusion requirements
    • the mean interval between transfusions increased 29.5%
    • overall, Hemoglobin levels were not compromised by reduced
    transfusion volumes

    05/29/08 11:56 PM
    The Inferences drawn….
     Chlorophyll is enhancing the Hemoglobin
    function.

     Induction of fetal Hemoglobin (Hb F)

    05/29/08 11:56 PM
    So what the experts say…
     No role of chlorophyll.
     There is no measurable amount of HbF
    formed
     It is basically a food supplement that
    contains Oxalic and Malic acids that trap
    iron in RBCs and slow down their decay
     The extract was also found to reduce
    absorption of iron in the intestine.
     Anti-oxidizing properties of the juice

    05/29/08 11:56 PM
    The 7 Day wonder …..
    th

    05/29/08 11:56 PM
    Added Benefits??
     It doesn’t contains appreciable amount of
    Iron.
     It contains; vitamins A, C, E, K, B1, B2, B6,
    B12; Niacin, Pantothenic acid, Biotin, Folic
    acid; Chlorophyll, Superoxide dismutase;
    Calcium, Phosphorus, Potassium,
    Magnesium,iron, Selenium, Zinc, Iodine,
    Copper, Cobalt, Sulphur, and other trace
    minerals; and twenty amino acids.

    05/29/08 11:56 PM
    How can I help the cause of
    Thalassemia?

     Get yourself tested for Thalassemia Minor


     For care of Thalassaemia Major children :
     Donate blood regularly.
     Provide financial support for Thalassemia
    patients.

    05/29/08 11:56 PM
    References:
     1. Kirkman, N.F. 1939. The effect of low-porphyrin diet on erythropoiesis
    and hemoglobin regeneration. J Physiol 95:508-515
     2. Kelentei, B., Fekete, I., Kun, F. 1958. Influence of copper chlorophyllin on
    experimental anemia. Acta Pharm Hung28:176-180
     3. Borisenko, A.N., Sofonova, A.D. 1965. Hemopoietic effect of Na
    chlorophyllin. Vrach Delo 9:44-46
     4. Gruskin, B. Chlorophyll – its therapeutic place in acute and suppurative
    disease. 1940. American Journal of Surgery.
     5. Collings, G. 1945. Chlorophyll and adrenal cortical extract in the local
    treatment of burns. American Journal of Surgery70:58- 63.
     6. Egner, P.A., Munoz, A., Kensler, T.W. 2003. Chemoprevention with
    chlorophyllin in individuals exposed to dietaryaflatoxin. Mutat Res. 2003
    Feb-Mar;523-524:209-16.
     7. Ben-Ayre, E., Goldin, E., Wengrower, D., Stamper, A., Kohn, R., Berry ,
    E. 2002. Wheat grass juice in the treatment of active distal ulcerative colitis:
    a randomized double-blind placebo-controlled trial. Scand J Gastroenterol
    2002;37:444-449

    05/29/08 11:56 PM
    05/29/08 11:56 PM

    You might also like