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Outcome and Prognosis GDD

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Curriculum vitae

Nama : dr. Alifiani Hikmah Putranti SpA(K


Pendidikan S1 : Fakultas Kedokteran UGM ,1987
Pendidikan Spesialis : Dokter SpesialisAnak, FK Undip 1989
Dokter Spesialis Anak Konsultan Syaraf Anak 2006.
Pekerjaan : Kepala divisi Neurologi Anak.Departemen/KSM
Ilmu Kesehatan Anak FK UNDIP/RSUP Dr. Kariadi
Outcome and Prognosis
Global Developmental Delay
Alifiani Hikmah Putranti
Objective

• Etiology and diagnose of GDD

• Predictor of severity and outcome GDD

• Outcome GDD
Why is finding an aetiology important ?
• Prognostic information

• Prevent co-morbidity

• Appropriate counselling about recurrence risk

• Accessing more support

• Treatment
Problem of diagnose
• Neurologia 2014;29(7):402-407

31%

Diagnose
(+)
Outcome GDD at scholl age
Languange skill

Motoric

Cognitive

Academic performance
Development Medicine & Child Neurology 2005,4:68-83
Language and motoric
(Shevell M et all 2005)

BDI
Measures of developmental ability;
Motor,adaptive,communication,cognitive,
personal social

VABS
Measures of functional status of
communication, socialization ,daily living
skill and communication

BDI and VABS score are low

Developmental Medicine & Child Neurology 2005; 47:678-83


Developmental and Functional ourcome of GDD
(Shevell M et all 2005)
Functional performance of school children with GDD ( Lilian de Fatima D et all 2015)

Participation in school environment <<

Cognitive and behavioral <<

Activity performance <<

Rev Paul Pediatr, 2016;34(1);78-85


Special school needed for children with history of GDD
(Shevell M et all 2005)

53,2 % Children with history of GDD need special class / special school

Developmental medicine and child neurology 2005,4: 68-83


Outcome GDD

• Children with GDD need help during school tasks


(cognitive and behavioural)
• (J.Child Neurol 2016;31 (1041-1051)

• Persistent difficulties with motor deficit, restriction and


low participation in school activity
• (Rev Paul Pediatr,2016;34(1): 8-85 )

• At school age, children of GDD show persistent and consistenly


poor performance across all developmental and functional
domains (BDI and VABS)
• ( J.child Neurol 2005;20:648-654)


Global developmental delay and its relationship to cognitive skills ( Emilie et all 2009)

73 % of children with history of GDD displaying a global IQ score below average normal IQ

Development medicine Child Neurology 2009,51:600-606


Factors that can affect the level of IQ

Performance IQ correlated with


Expressive languange and Fine motor
scores

Development medicine Child Neurology 2009,51:600-606


Predictor of severity and outcome GDD

• Prematurity
• IUGR
• Low socioeconomic
• Non compliance to habilitaton plan

BMC Pediatrics 2014 14:40


Prematurity ,IUGR ?
• Prematurity :
• Interruption of brain development at early and critical neurodevelopment
stages
• Pertubs the trajectory of normal cerebral development after birth
• IUGR
• Disturbances in the architecture and maturation of the developing cortical
neuron network
Summary

Outcome global developmental delay

1. Etiology Global Developmental Delay

2. Predictors outcome of GDD


o Perinatal factors : IUGR,prematurity,neonatal hypoxia
o Low social economy
o Poor compliance to habilitation plan
summary
3. School age performance of children with history of GDD

• Regular school 17 %,
• Developmental and Functional status
• Batelle Developmental Inventory score is low
Vineland Adaptive Behaviour Scale score is low
• IQ score 73% less than 90 (average)

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