PTDO Slide PDF
PTDO Slide PDF
PTDO Slide PDF
Teknologi
Desain
Obat Deni Iskandar, S.Si., Apt., MPH.
@deniiskandar
Pengantar
Teknologi
Desain • Introduction to Pharmaceutical Industry
Obat
• Pharmaceutical Product Life Cycle
• Innovation: The Process of Drug Discovery
• Portfolio Management in New Drug
Development
• Regulatory
• Pharmaceutical Care
• Future of Pharmaceutical Industry
Introduction to Pharmaceutical Industry
Secara luas
Meliputi semua org yg terlibat/dibutuhkan, mulai dr obat
itu msh “diangankan” oleh seorg ahli sampai mjd produk
jadi dan dikonsumsi o/pasien/penderita
Secara sempit
Riset obat-obatan dan manufakturnya/ perusahaan
farmasi yg menyediakan obat u/diracik dlm bentuk obat
atau sediaan siap pakai o/ para ahli farmasi di ruang
lingkup praktiknya
Pharmaceutical industry:
Companies engaged in researching, developing,
manufacturing, and marketing drugs and biologicals for
human or veterinary use
http://www.trade.gov/td/health/PharmaceuticalIndustryProfile2010.pdf
- Linked to science
- More regulated: impact people’s quality of life
https://www.firstwordpharma.com/node/1408804
In Ding, M., In Eliashberg, J., & In Stremersch, S. (2014). Innovation and marketing in the pharmaceutical industry: Emerging practices, research, and policies.
Innovation
Marketing
http://www.firstwordpharma.com/node/1211072#axzz3xz4tAZ7x
• Empowered consumer
Economics
Innovation: The Process of Drug Discovery
Drug discovery:
• 2000: total cost of new drug was $803 mil
• 2005: total cost of new drug was $1.3 bil
• Approximately 50% for R&D
Economics
Innovation: The Process of Drug Discovery
Before WWII:
• pharmaceutical industry and life science was
relatively tenuous
• Derived from/based on natural sources (herb)
• Little formal testing on safety and efficacy
• War instigated needs of antibiotics
History
Innovation: The Process of Drug Discovery
After the war:
• Faced a vast set of diseases and disorders
with no known cures
• Random screening
• Mid-1970, advancement in science propelled
the understanding of the biochemical and
molecular mechanism of diseases and action
pathway of existing drug
• Most of drugs derived from nature, organic
synthesis, fermentation
• Early 1980, biotechnology, genetic
engineering
History