Pola Pengenalan Patogen
Pola Pengenalan Patogen
Pola Pengenalan Patogen
rina_susilowati@ugm.ac.id 2012
rina_susilowati@ugm.ac.id 2012
T
B
Macrophages
rina_susilowati@ugm.ac.id 2012
Dendritic
cells
Injured
cells
Altered self
Pathogens
(non self)
pathogen associated
molecular patterns
(PAMPs) e.g LPS, high
mannose
damage associated
molecular patterns
(DAMPs)
Eat
me
Normal
cells (self)
self-associated molecular
patterns (SAMPs)
Eat
me
Dont
eat me
Macrophages
Inflammation
rina_susilowati@ugm.ac.id 2012
Macrophages
rina_susilowati@ugm.ac.id 2012
rina_susilowati@ugm.ac.id 2012
Receptor
Ligands
Lipoteichoic acid
TLR2
Lipoproteins
Peptidoglycan
Lipoarabinomannan
Porins
Envelope glycoproteins
GPI-mucin
Phospholipomannan
Zymosan
-Glycan
TLR3
dsRNA
TLR4
LPS
Envelope glycoproteins
Glycoinositolphospholipids
Mannan
HSP70
TLR5
Flagellin
TLR7/8
ssRNA
TLR9
CpG DNA
Clin Microbiol Rev. 2009 April; 22(2): 240273.
rina_susilowati@ugm.ac.id 2012
Origin(s)
Bacteria
Mycoplasma
Gram-positive bacteria
Various pathogens
Gram-positive and -negative bacteria
Mycobacteria
Neisseria
Viruses (e.g., measles virus, HSV, cytomegalovirus)
Protozoa
Candida
Fungi
Fungi
Viruses
Gram-negative bacteria
Viruses (e.g., RSV)
Protozoa
Candida
Host
Flagellated bacteria
RNA viruses
Viruses, bacteria, protozoa
Dectin-1
C-type lectin that binds b-glucancontaining particles including
zymosan and C. albicans
Macrophage Scavenger
Receptor (SR-A)
Recognize certain anionic
polymers and low-density
lipoproteins
rina_susilowati@ugm.ac.id 2012
Receptor
Ligands
RLRs
RIG-I
MDA5
rina_susilowati@ugm.ac.id 2012
Origin(s)
Viruses (e.g., influenza A virus, HCV, RSV)
Viruses (picorna- and noroviruses)
Receptor
NLRs
NOD1
NOD2
NALP1
NALP3
Ligands
Diaminopimelic acid
MDP
MDP
ATP, uric acid crystals, RNA,
DNA, MDP
Origin(s)
Gram-negative bacteria
Gram-positive and -negative bacteria
Gram-positive and -negative bacteria
Viruses, bacteria, and host
Clin Microbiol Rev. 2009 April; 22(2): 240273.
14
rina_susilowati@ugm.ac.id 2012
rina_susilowati@ugm.ac.id 2012
16
rina_susilowati@ugm.ac.id 2012
Pathogen-induced
TLR signaling in
immature dendritic
cells
induces their
migration to
lymphoid organs
and
enhances antigen
processing
rina_susilowati@ugm.ac.id 2012
rina_susilowati@ugm.ac.id 2012
rina_susilowati@ugm.ac.id 2012
Receptors/Sensors
Retroelements
ND
Mitochondria DNA
TLR9
Formyl peptides
FPRL1/2
NLRP3
Uric acid
NLRP3
Cholesterol crystals
NLRP3
Alum
NLRP3
Sialoside-based
pattern recognition
as a negative
regulator for innate
immune responses
rina_susilowati@ugm.ac.id 2012
http://www.seas.upenn.edu/~discher/research.html
rina_susilowati@ugm.ac.id 2012
rina_susilowati@ugm.ac.id 2012
Summary
Pattern recognition by cells of the innate immune system
24
Recognition of danger
signals leads to
engulfment of pathogen
or damage cells,
inflammation and
activation of adaptive
immunity
Thank You
rina_susilowati@ugm.ac.id 2012