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    Aspirin

    Uploaded by

    Darwin Mangabat
    Aspirin can be synthesized from salicylic acid through an esterification reaction with acetic anhydride catalyzed by sulfuric acid. The students weighed salicylic acid and acetic anhydride and mixed them with sulfuric acid in a water bath for 20-30 minutes. They then added water, crystallized the aspirin, and filtered and dried it. Tests on the synthesized aspirin found it had similar properties to commercially available aspirin, including a melting point of 138-140°C, but the synthesized aspirin did not contain starch, which is sometimes added to commercial aspirin as a binder.

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    Aspirin

    Uploaded by

    Darwin Mangabat
    139 views2 pages
    Aspirin can be synthesized from salicylic acid through an esterification reaction with acetic anhydride catalyzed by sulfuric acid. The students weighed salicylic acid and acetic anhydride and mixed them with sulfuric acid in a water bath for 20-30 minutes. They then added water, crystallized the aspirin, and filtered and dried it. Tests on the synthesized aspirin found it had similar properties to commercially available aspirin, including a melting point of 138-140°C, but the synthesized aspirin did not contain starch, which is sometimes added to commercial aspirin as a binder.

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    synthesis

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    aspirin.docx

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    Aspirin can be synthesized from salicylic acid through an esterification reaction with acetic anhydride catalyzed by sulfuric acid. The students weighed salicylic acid and acetic anhydride and mixed them with sulfuric acid in a water bath for 20-30 minutes. They then added water, crystallized the aspirin, and filtered and dried it. Tests on the synthesized aspirin found it had similar properties to commercially available aspirin, including a melting point of 138-140°C, but the synthesized aspirin did not contain starch, which is sometimes added to commercial aspirin as a binder.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    139 views2 pages

    Aspirin

    Uploaded by

    Darwin Mangabat
    Aspirin can be synthesized from salicylic acid through an esterification reaction with acetic anhydride catalyzed by sulfuric acid. The students weighed salicylic acid and acetic anhydride and mixed them with sulfuric acid in a water bath for 20-30 minutes. They then added water, crystallized the aspirin, and filtered and dried it. Tests on the synthesized aspirin found it had similar properties to commercially available aspirin, including a melting point of 138-140°C, but the synthesized aspirin did not contain starch, which is sometimes added to commercial aspirin as a binder.

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    © All Rights Reserved
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    Download as docx, pdf, or txt
    of 2

    SYNTHESIS OF ASPIRIN

    LEGASPI Jhoe Cynder; LIWAG, James Timothy; MANGABAT, Allison Mae;


    MARIANO, Jedidiah, MELAD, Mikee

    UNIVERSITY OF SANTO TOMAS
    FACULTY OF PHARMACY

    Background of the study

    Aspirin is the common name for the compound acetylsalicylic acid, widely used as a fever
    reducer and as a pain killer

    While Salicylic acid, whose name comes from Salix, the willow family of plants, was derived from willow
    bark extracts. In folk medicine, willow bark teas were used as headache remedies and other tonics.
    Nowadays, salicylic acid is administered in the form of aspirin which is less irritating to the stomach than
    salicylic acid.

    Materials:
    Hard glass test tubes, 10-mL graduated cylinder, dropping pipette, beaker, thermometer,
    stirring rod, filter paper, funnel

    Methods
    We weighed 2grams of salicylic acid and we transferred it to a hard glass test tube. Then we
    added exactly 5mL of acetic anhydride. 5 drops of concentrated Sulphuric acid was added to the salicylic
    acid and the mixture was stirred until it dissolved. The test tube containing the compound was placed in
    a waterbath with a temperature of 70-80C for 20 to 30 minutes with occasional stirring. Room
    temperature water was added until the mixture turned cloudy. When we removed the solution from the
    water bath, we scratched the inner wall of the test tube and rinsed it with ice cold water. On a beaker,
    we placed the rinsing and added 20mL of ice water to it and stirred. We allowed the aspirin to crystallize
    by placing the beaker on an ice bath for 10 minutes. Then we filtered the solution in a pre-weighed filter
    paper and allowed to dry. Afterward, the aspirin was weighed and placed in an amber bottle.

    On the next part, we tried to determine the melting point of the synthesized aspirin. We placed
    the aspirin inside capillary tubes then tied it to a thermometer and placed it in cooking oil. Then the
    melting point range was measured. The 'melting point' is the range from the appearance of the first
    liquid droplet until complete melting of the crystals. The expected melting point of aspirin is 138-140 C.

    Purity of Aspirin was tested with 2 different tests; The Ferric Chloride Test for Salicylic acid and
    the starch test. Wherein in the Ferric Chloride test for salicylic acid, each test tube contained Salicylic
    acid, commercially available aspirin, prepared aspirin, Benzoic acid, Benzyl alcohol and Control which is
    water, respectively then a drop of Ferric Chloride was added in each test tube and the color was noted.
    While in the Starch test, each test tube contained prepared aspirin, commercially available aspirin and
    the control which is water. A drop of iodine solution was added in each and the color was noted.





    Conclusions

    It can be concluded that Acetylsalicylic acid, commonly known as aspirin, could be synthesized using
    salicylic acid, and acetic anhydride catalyzed with sulfuric acid. Aspirin can be made using the process of
    esterification. It is when a carboxylic acid which is the salicylic acid and an alcohol, which is the acetic
    anhydride that became an acetic acid, an alcohol, combine to form an ester, acetylsalicylic acid.
    The aspirin is insoluble in cold water, so it can be isolated by filtering the chilled reaction solution.
    Purification is necessary to remove any unreacted salicylic acid and acetic anhydride, as well as the
    acetic acid product and phosphoric acid. Acetic anhydride is made to decompose by the addition of
    water once the formation of aspirin is complete.
    Also, the prepared Aspirin is very much similar to the commercially available aspirin except that when
    starch test was made to both the prepared and commercially available aspirin, only the commercially
    available aspirin showed a positive result which was light violet indicating the presence of starch in it.
    Starch is widely used as a binder in medicines.

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