Revised Guidelines For HIV Counseling, Testing, Referral
Revised Guidelines For HIV Counseling, Testing, Referral
Revised Guidelines For HIV Counseling, Testing, Referral
RR-19
Inside: Two Continuing Education Examinations Inside: Continuing Continuing Medical Education for U.S. U.S. Physicians and and Nurses Nurses Inside: Medical Education for Physicians
and
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention (CDC) Atlanta, GA 30333
The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services, Atlanta, GA 30333. SUGGESTED CITATION Centers for Disease Control and Prevention. Revised Guidelines for HIV Counseling, Testing, and Referral and Revised Recommendations for HIV Screening of Pregnant Women. MMWR 2001;50(No. RR-19):[inclusive page numbers].
Centers for Disease Control and Prevention .................. Jeffrey P. Koplan, M.D., M.P.H. Director The material in this report was prepared for publication by National Center for HIV, STD, and TB Prevention ....................... Harold W. Jaffe, M.D. Acting Director Division of HIV/AIDS Prevention Surveillance and Epidemiology .............................................................. Robert S. Janssen, M.D. Director The production of this report as an MMWR serial publication was coordinated in Epidemiology Program Office ............................................ Barbara R. Holloway, M.P.H. Acting Director Office of Scientific and Health Communications ........................ John W. Ward, M.D. Director Editor, MMWR Series
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Contents
Revised Guidelines for HIV Counseling, Testing, and Referral ........................ 1 Introduction ......................................................................................................... 1 Targeted Versus Routinely Recommended HIV CTR ......................................... 7 HIV Counseling ................................................................................................. 13 HIV Testing ........................................................................................................ 27 HIV Referral ....................................................................................................... 36 HIV CTR Services in Nontraditional Settings .................................................. 39 Quality Assurance and Evaluation of HIV CTR Services ................................. 43 Conclusion ........................................................................................................ 45 Additional Resources ........................................................................................ 45 References ......................................................................................................... 46 Glossary ............................................................................................................ 54 Continuing Education Examination ..................................................... CE-1-19a1 Revised Recommendations for HIV Screening of Pregnant Women ............. 59 Introduction ....................................................................................................... 63 Background ....................................................................................................... 65 Recommendations ............................................................................................ 75 Conclusions ...................................................................................................... 81 References ......................................................................................................... 81 Continuing Education Examination ..................................................... CE-1-19a2
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Notice to Readers
This MMWR contains two articles, each with a continuing education examination. Each examination is printed on blue paper and placed directly after its accompanying article. The first examination is labeled RR-19a1, and the second is labeled RR-19a2. Please make sure you complete and submit the correct response form for the article for which you want to receive continuing education credit. You may take both examinations and receive credit for both articles.
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Technical Expert Panel Review of CDC HIV Counseling, Testing, and Referral Guidelines February 1819, 1999 Atlanta, Georgia
Terje J. Anderson National Association of People with AIDS Washington, D.C. David Atkins, M.D., M.P.H. Agency for Healthcare Research and Quality Rockville, Maryland Catherine Baker-Cirac California Office of AIDS Sacramento, California Ronald Bayer, Ph.D. Columbia University New York, New York Frank K. Beadle de Palomo, M.A. Academy for Educational Development Washington, D.C. Gail A. Bolan, M.D. California Department of Health Berkeley, California Carol A. Browning, M.S. Rhode Island Department of Health Providence, Rhode Island Scott Burris, J.D. Temple University Philadelphia, Pennsylvania Amy S. DeGroff, M.P.H. Centers for Disease Control and Prevention (CDC) Atlanta, Georgia John M. Douglas, M.D. Denver Public Health Denver, Colorado Martin Fishbein, Ph.D. University of Pennsylvania Philadelphia, Pennsylvania Alice A. Gandelman, M.P.H. California STD Control Branch Berkeley, California Cynthia A. Getty CDC Atlanta, Georgia Lawrence O. Gostin, J.D., L.L.D. Georgetown University Washington, D.C. Khurram S. Hassan, M.P.H. United Way of Metro Atlanta Atlanta, Georgia Thomas L. Hearn, M.S., Ph.D. CDC Atlanta, Georgia Michael P. Johnson, M.D., M.P.H. Health Resources and Services Administration Rockville, Maryland William J. Kassler, M.D., M.P.H. New Hampshire Department of Health & Human Services Concord, New Hampshire Marlene LaLota, M.P.H. Florida Department of Health Tallahassee, Florida Michael K. Lindsay, M.D., M.P.H. Emory University Atlanta, Georgia Michael H. Merson, M.D. Yale University New Haven, Connecticut Stephen F. Morin, M.A., Ph.D. University of California, San Francisco San Francisco, California James Pearson, M.P.H., Ph.D. Division of Consolidated Laboratory Services Richmond, Virginia Beny J. Primm, M.D. Urban Resources Institute Brooklyn, New York
Vol. 50 / No. RR-19 Joel Rosenstock, M.D., M.P.H. Infectious Disease Solutions, P.C. Atlanta, Georgia Peter Salovey, Ph.D. Yale University New Haven, Connecticut Charles A. Schable, M.S. CDC Atlanta, Georgia Kathleen J. Sikkema, Ph.D. Yale University New Haven, Connecticut Edith Springer, M.S.W. Edith Springer Associates Brooklyn, New York Janis Spurlock-McLendon, M.S.W. Connecticut Department of Public Health Hartford, Connecticut Lee Trevithick, M.A. Cocoon House Everett, Washington James Welch Division of Public Health Dover, Delaware
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The following CDC staff members prepared this report: Beatrice T. Divine, M.A. Stacie M. Greby, D.V.M., M.P.H. Kenneth V. Hunt Mary L. Kamb, M.D., M.P.H. Richard W. Steketee, M.D., M.P.H. Lee Warner, M.P.H. Division of HIV/AIDS Prevention Surveillance and Epidemiology National Center for HIV, STD, and TB Prevention in consultation with Liisa M. Randall, M.A. National Alliance of State and Territorial AIDS Directors
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BOX 1. HIV counseling, testing, and referral (CTR) settings Settings that provide HIV CTR include but are not limited to the following traditional clinical and nontraditional settings: Adolescent health clinics, school-based health centers, university health centers AIDS services organizations Clinics serving men who have sex with men Community-based organizations Community health centers Correctional facilities Drug or alcohol prevention and treatment programs Family planning clinics Freestanding HIV test sites Hospital emergency departments Hospitals/other urgent care centers Managed care organizations Mens health clinics Migrant health centers Occupational/employee health clinics Outreach programs (e.g., syringe exchange programs) Prenatal clinics Private-sector service providers Publicly funded counseling and testing sites Sexually transmitted disease clinics Tuberculosis clinics Womens health clinics
[STD] clinics, private physicians offices) and nontraditional settings (e.g., communitybased or outreach settings [homeless shelters, bars]), which can be important places to provide access to CTR to persons at increased HIV risk. The Public Health Service is responsible for ensuring the quality of services in publicly funded programs, and many aspects of these guidelines focus on such programs. The guidelines could also be useful for CTR in other settings (e.g., for insurance, military, and blood donation purposes). Recommendations should be tailored to fit the needs of clients, communities, and programs within local, state, and federal rules and regulations.
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Because of recent advances in HIV treatment and prevention (532, Revised Recommendations for HIV Screening of Pregnant Women ), CDC consulted with multiple partners to revise the 1994 guidelines using an evidence-based approach (33,34 ) and to expand the target audience to all providers of HIV CTR in the United States (33 ). Where scientific findings were lacking, recommendations were guided by best practices from specialists in the field. These guidelines were developed through the following five-step approach: Address user needs. A survey was conducted of publicly funded sites that offer HIV CTR to assess user satisfaction with the 1994 CDC guidelines for HIV CTR. Internal and external content specialists were consulted on key areas to address. Review scientific literature. Approximately 5,000 abstracts were screened and approximately 600 relevant publications were reviewed and synthesized where appropriate. Approximately 20 previously published CDC guidelines related to HIV CTR also were summarized. Obtain technical opinion. A panel of technical specialists from public and private sectors; governmental and nongovernmental agencies; and legal, ethics, and policy fields was convened to review the recommendations. Obtain user input. Internal CDC comments, public and private provider assessments, key consultant interviews, broad external reviews, and public comments through the Federal Register were obtained. Publish electronically and in hard copy. Single copies of this report are available from CDCs National Prevention Information Network (NPIN) website at <http:// www.cdcnpin.org> or by calling (800) 458-5231. The guidelines are also available at the HIV Counseling, Testing, and Referral website at <http://www.cdc.gov/hiv/ ctr>. They will be updated and posted periodically.
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Differences in the new guidelines include giving guidance to all providers of voluntary HIV CTR in the public and private sectors; using an evidence-based approach to provide specific recommendations for CTR; underscoring the importance of early knowledge of HIV status and making HIV testing more accessible and available; acknowledging providers need for flexibility in implementing the guidelines, given their particular client base, setting HIV prevalence level, and available resources; recommending that CTR be targeted efficiently through risk screening and other strategies; and addressing ways to improve the quality and provision of HIV CTR.
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blood), in addition to serum specimens collected by venipuncture. Rapid HIV testing allows clients to receive results the same day, which is useful in urgent medical circumstances and settings where clients tend not to return for HIV test results (e.g., some STD clinics). HIV testing can also be conducted using commercially available home sample collection devices (52 ). Also during the 1990s, randomized controlled trials demonstrated that, for persons at increased HIV risk, certain prevention counseling approaches can be effective in reducing high-risk behaviors and new sexually transmitted infections (5,1821 ). The counseling approach used is critical to effectiveness; interactive counseling approaches directed at a clients personal risk and the situations in which risk occurs are more effective than didactic, informational approaches (5 ). Because personalized prevention counseling can require more provider time and training than traditional counseling approaches, providing it to everyone receiving HIV testing might not be feasible. This recognition has led to a new area of health services research developing strategies that effectively target CTR services to persons most likely to benefit from them. The improved health of HIV-infected persons on antiretroviral therapy, along with new test technologies and effective counseling approaches, has contributed to an improved understanding of the importance of referral to needed services. In addition, new guidelines for partner counseling and referral services (PCRS) (27 ) and prevention case management (28 ) were developed specifically for publicly funded clinics and could also be useful to providers in other settings. Specialists in the field have also identified situations in which additional counseling or psychosocial support services might benefit HIV prevention efforts. Finally, advances in several areas have led to new guidelines for preventing mother-to-child transmission (see Revised Recommendations for HIV Screening of Pregnant Women ), treating opportunistic infections (23,53 ) and other sexually transmitted (29 ) and bloodborne diseases (3032 ), and managing occupational and nonoccupational exposure and prophylaxis (54,55 ). These developments were considered in the formulation of the new CTR guidelines. Despite these advances in HIV prevention and care, a substantial number of opportunities for HIV prevention through CTR are missed. At publicly funded sites, approximately 70% of persons tested received their results and information regarding the test, but fewer persons likely received HIV prevention counseling and referrals. In private settings, a lower proportion of all clients are tested, and few receive prevention counseling and referrals (5659 ). In many potential testing settings (e.g., emergency departments), HIV prevention counseling and testing are not uniformly offered, and data regarding types, completion, and effectiveness of referrals are not routinely collected.
* Delivered according to recommended protocols (for counseling, referral, and evaluation) or regulatory standards (for testing).
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have access to appropriate medical, preventive, and psychosocial support services. Promote early knowledge of HIV status through HIV testing and ensure that all persons either recommended or receiving HIV testing are provided information regarding transmission, prevention, and the meaning of HIV test results.
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Adhere to local, state, and federal regulations and policies that govern provision of HIV services. Laws at the local, state, and federal levels might address aspects of HIV services or regulate how services are provided to particular persons (e.g., minors). In addition, policies, local ordinances, funding source requirements, and planning processes could also affect a providers decisions regarding which services to provide and how to provide them. Provide services that are responsive to client and community needs and priorities. Providers should work to remove barriers to accessing services and tailor services to individual and community needs. To ensure that clients find services accessible and acceptable, services can be offered in nontraditional settings (i.e., community-based or outreach settings); hours of operation can be expanded or altered; unnecessary delays can be eliminated (e.g., integrating counseling and testing for STDs/HIV with counseling and testing for hepatitis); test results can be obtained more easily (e.g., with rapid testing or by telephone in certain situations); and less-invasive specimen collection can be used (e.g., oral fluid, urine, or finger-stick blood). Provide services that are appropriate to the clients culture, language, sex, sexual orientation, age, and developmental level. These factors could affect how the client seeks, accepts, and understands HIV services. Providers should consider these factors when designing and providing HIV services to increase the likelihood of return for test results and acceptance of counseling and referral services. Ensure high-quality services. To ensure ongoing, high-quality services that serve client and community needs, providers should develop and implement written protocols for CTR and written quality assurance and evaluation procedures. Many state and local health departments have substantial expertise in providing and monitoring the quality of HIV CTR services and can be a resource to private providers or community-based or outreach settings initiating these services.
Routinely Recommending CTR to All Clients Versus Targeting CTR to Selected Clients
Studies have documented that, in settings serving clients at increased behavioral and clinical risk for HIV infection, targeting HIV testing based on reported risk factors will miss many HIV-infected clients (6169 ). However, in low prevalence settings, where most clients have minimal risk, targeting clients for HIV testing based on risk screening might be more feasible for identifying small numbers of HIV-infected persons (70 ). Providers should consider three factors in determining whether to recommend HIV CTR to all clients or to target only selected clients.
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Type of setting. HIV prevalence of the setting. Behavioral and clinical HIV risk of the individual clients in the setting. Although certain types of settings serve populations at increased risk (e.g., STD clinics), others might serve individual clients at increased risk (e.g., private physicians offices in areas of low prevalence). Individual risk can be ascertained through risk screening. Under certain circumstances perinatal transmission, acute occupational exposure, and acute nonoccupational (i.e., high-risk sexual or needle-sharing) exposure providers should recommend HIV CTR regardless of setting prevalence or behavioral or clinical risk, based on the respective guidelines (Revised Recommendations for HIV Screening of Pregnant Women,54,55 ).
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BOX 2. Examples of two risk-screening strategies to elicit client-reported HIV risks Open-ended question by provider, What are you doing now or what have you done in the past that you think may put you at risk for HIV infection? Screening questions* (i.e., a checklist) for use with a self-administered questionnaire, face-to-face or computer-assisted interview, or other instrument: Since your last HIV test (if ever), have you injected drugs and shared equipment (e.g., needles, syringes, cotton, water) with others?
had unprotected intercourse with someone that you think might be infected (e.g., a partner who injected drugs, has been diagnosed or treated for a sexually transmitted disease [STD] or hepatitis, has had multiple or anonymous sex partners, or has exchanged sex for drugs or money)? had unprotected vaginal or anal intercourse with more than one sex partner? been diagnosed or treated for an STD, hepatitis, or tuberculosis? had a fever or illness of unknown cause? been told you have an infection related to a weak immune system?
* Clients who respond affirmatively to >1 of these questions should be considered at increased risk for HIV.
Recommendations for Routinely Recommended and Targeted CTR by Setting and Circumstance
Decisions regarding whether to recommend routine or targeted services are based on the behavioral and clinical HIV risk of the client population in the setting, the level of HIV prevalence of the setting, and the behavioral and clinical HIV risk of individual clients (Box 3). These factors should not be used to determine recommendations for CTR in circumstances in which treatment potential exists (i.e., perinatal transmission and acute occupational or nonoccupational exposure).
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BOX 3. Clients who should be recommended HIV prevention counseling, testing, and referral All clients in settings serving client populations at increased behavioral or clinical HIV risk (regardless of setting HIV prevalence). Individual clients in settings with <1%* HIV prevalence who have clinical signs or symptoms suggesting HIV infection (e.g., fever or illness of unknown origin, opportunistic infection [including active tuberculosis disease] without known reason for immune suppression), have diagnoses suggesting increased risk for HIV infection (e.g., another sexually transmitted disease [STD] or bloodborne infection), self-report HIV risks (see Box 2), or specifically request an HIV test.
All clients in settings with a >1% HIV prevalence. Regardless of setting prevalence or behavioral or clinical risk, all pregnant women, all clients with possible acute occupational exposure, and all clients with known sexual or needle-sharing exposure to an HIV-infected person.
* Or lower than other settings in the community. Constitutes risk screening; see Determining Individual HIV Risk Through Risk Screening. Or higher than other settings in the community. Clients should be routinely recommended testing, and if risk is identified during risk screening, they should also be recommended HIV prevention counseling and referral.
BOX 4. Examples of settings that serve populations at increased behavioral or clinical risk for HIV infection Adolescent or school-based health clinics with high rates of sexually transmitted diseases (STD) Clinics serving men who have sex with men Correctional facilities, prisons, juvenile detention centers Drug or alcohol prevention and treatment programs
* Only persons with confirmed or suspected TB and their contacts should routinely be recommended HIV CTR.
Freestanding HIV test sites Homeless shelters Outreach programs (e.g., syringe exchange programs) STD clinics Tuberculosis (TB) clinics*
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FIGURE 1. An example of counseling, testing, and referral in settings serving populations at increased behavioral or clinical HIV risk
Client population HIV prevention counseling and HIV testing with informed consent and information Test () Referral to medical, prevention, and support services, if applicable Test (+) Referral to medical, prevention, and support services
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FIGURE 2. An example of HIV counseling, testing, and referral in low prevalence settings
Client population
Risk screening
Risk
No risk
HIV prevention counseling and HIV testing with informed consent and information
FIGURE 3. An example of HIV counseling, testing, and referral in high prevalence settings
HIV prevention counseling and HIV HIV testing testing with informed consent with informed consent and information and information Test () Test (+) Referral to medical, prevention, and support services Test ()
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target pregnant women based on risk screening and be routinely recommended to clients with either acute occupational or nonoccupational exposures. For further information, consult the respective guidelines on perinatal transmission, acute occupational exposure, and acute nonoccupational exposure (Revised Recommendations for HIV Screening of Pregnant Women,54,55 ).
HIV COUNSELING
HIV counseling seeks to reduce HIV acquisition and transmission through the following: Information. Clients should receive information regarding HIV transmission and prevention and the meaning of HIV test results. Provision of information is different from informed consent. HIV prevention counseling. Clients should receive help to identify the specific behaviors putting them at risk for acquiring or transmitting HIV and commit to steps to reduce this risk. Prevention counseling can involve >1 sessions.
Information
All clients who are recommended or who request HIV testing should receive the following information, even if the test is declined: Information regarding the HIV test and its benefits and consequences. Risks for transmission and how HIV can be prevented. The importance of obtaining test results and explicit procedures for doing so. The meaning of the test results in explicit, understandable language.* Where to obtain further information or, if applicable, HIV prevention counseling. Where to obtain other services (see Typical Referral Needs).
* For example, A negative test means no HIV was found. But if you were exposed to HIV recently in the last 12 months this test may not be able to pick that up. See Negative HIV Test Results.
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In certain settings where HIV testing is offered, other useful information includes a) descriptions or demonstrations of how to use condoms correctly; b) information regarding risk-free and safer sex options (73 ); c) information regarding other sexually transmitted and bloodborne diseases; d) descriptions regarding the effectiveness of using clean needles, syringes, cotton, water, and other drug paraphernalia; e) information regarding drug treatment; and f) information regarding the possible effect of HIV vaccines on test results for persons participating in HIV vaccine trials (see Additional Counseling Considerations for Special Situations and Positive HIV Test Results). For efficiency, information can be provided in a pamphlet, brochure, or video rather than a face-to-face encounter with a counselor. This approach allows the provider to focus face-to-face interactions on prevention counseling approaches proven effective with persons at increased risk for HIV infection. Information should be provided in a manner appropriate to the clients culture, language, sex, sexual orientation, age, and developmental level. Certain informational videos and large-group presentations that provide explicit information regarding correct use of condoms have proven effective in reducing new STDs (1921,74 ) and could be effective in reducing HIV.
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testing approach in which clients are physically present at a setting for the HIV test (initial session) and then return for HIV test results (follow-up session). Each session might require 1520 minutes (including testing and referral) for clients at increased risk for HIV, but could take only a few minutes for those at lower risk. In the first session, a personalized risk assessment* encourages clients to identify, understand, and acknowledge the behaviors and circumstances that put them at increased risk for acquiring HIV. The session explores previous attempts to reduce risk and identifies successes and challenges in these efforts. This in-depth exploration of risk allows the counselor to help the client consider ways to reduce personal risk and commit to a single, explicit step to do so. In the second session, when HIV test results are provided, the counselor discusses the test results, asks the client to describe the risk-reduction step attempted (and acknowledges positive steps made), helps the client identify and commit to additional behavioral steps, and provides appropriate referrals (e.g., to PCRS). In one large, randomized, controlled trial, this model was reported to be effective at reducing high-risk sexual behaviors and new STDs (5 ); feasible to use even in busy publicly funded clinics; acceptable to clients, counselors, and health-care providers (80 ); and cost-effective at preventing STDs in persons at increased risk for HIV (8183 ). The model was reported to be especially effective among adolescents and persons with ongoing sexual risk behaviors (e.g., newly diagnosed STDs) (5 ). Although the benefits of client-centered HIV prevention counseling in reducing high-risk drug behaviors are unknown, studies have indicated that similar counseling approaches that help clients explore risks and set specific risk-reduction goals reduce risky drug use behaviors (3941,84 ). Observational studies and reviews of programs in various settings have indicated that many counselors are still unfamiliar with the specific goals of the client-centered HIV prevention counseling model (75,85 ) (Amy S. DeGroff, M.P.H., written communication, 2000). Because client-centered is sometimes misinterpreted as face-to-face, providers in many HIV test sites deliver face-to-face informational messages in response to a generic checklist risk assessment. This type of counseling provides advice rather than encouraging client participation or discussion of personal risk; it seldom focuses on personal goal setting. Client-centered can also be misinterpreted to mean that the counselor should avoid directing the session. Although attentive listening and respect for clients concerns are important elements of effective counseling, the primary goal of client-centered HIV prevention counseling is risk reduction. HIV prevention counseling usually requires provider training and support and ongoing quality assurance to achieve optimal benefit. Providers can contact their state health departments HIV/AIDS program office for information on local training opportunities. For information on client-centered counseling with rapid testing, see Addressing Barriers to HIV Prevention Counseling.
* Personal risk assessment is an essential element of HIV prevention counseling in which the client and counselor work to understand and acknowledge the clients personal risk for HIV. Risk assessment is not synonymous with risk screening (see Determining Individual Client Risk Through Risk Screening and Box 2), which helps determine which clients should be recommended HIV CTR.
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BOX 5. Examples of closed-ended versus open-ended questions Closed-ended questions, which might interfere with client-centered human immunodeficiency virus (HIV) prevention counseling Have you ever injected drugs? OR Have you (for a male client) ever had sex with a man? OR Have you (for a female client) ever had sex with a bisexual man? Open-ended questions, which promote client-centered HIV prevention counseling
What are you doing that you think may be putting you at risk for HIV infection? What are the riskiest things that you are doing?
If your test comes back positive, how do you think you may have become infected? When was the last time you put yourself at risk for HIV? What was happening then? Have you ever had sex when you were under the influence of alcohol or drugs? How often do you use drugs or alcohol? How do you think drugs or alcohol influence your HIV risk? Do you (always) use condoms when you have sex? OR Can you always use condoms when you have sex? How often do you use condoms when you have sex? When/with whom do you have sex without a condom? When with a condom? What are you currently doing to protect yourself from HIV? How is that working? What kinds of things do you do to protect your partner from getting infected with HIV? (for HIV-infected clients) Tell me about specific situations when you have reduced your HIV risk. What was going on that made that possible? Can you always use clean works (i.e., needles, syringes, cottons, or cookers*) when you inject? How risky are your sex/needlesharing partners? For example, have they been recently tested for HIV?
* Cottons are filters used to draw up the drug solution. Cookers include bottle caps, spoons, or other containers used to dissolve drugs.
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BOX 6. Examples of global versus specific risk-reduction steps for HIV prevention counseling Global risk-reduction steps, which are unlikely to be effective in changing behavior Always use condoms. Specific risk-reduction steps, which are more likely to be effective in changing behavior Buy a condom tomorrow and try it on. Carry a condom next time I go out (e.g., to the bar/nightclub). Starting today, put condoms on the night stand beside the bed. Starting tonight, require my partner to use a condom next time, or I will not have vaginal (anal) sex. Have fewer or less risky partners. Stop seeing (specific partner) who is seeing other people. Break up with (specific partner) before getting together with someone new. Have safer sex. Talk honestly with (specific partner) about my HIV status and ask about his/her HIV status. Next time Im out with friends and may have sex, avoid getting high on drugs or alcohol. Only kissing, etc., with (specific partner) until we both have an HIV test. Tomorrow, ask (specific partner ) if he or she has had a recent HIV test and has been tested for other sexually transmitted diseases. Stop injecting drugs. Obtain clean works (i.e., needles, syringes, cottons, or cookers*) tomorrow so I have them before I use next time. Contact drug treatment center and make appointment.
* Cottons are filters used to draw up the drug solution. Cookers include bottle caps, spoons, or other containers used to dissolve drugs.
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HIV can be transmitted through the cooker, cotton, or water used by several persons sharing drugs. With newly identified or uninformed HIV-infected clients, the counselor should discuss HIV transmission risks associated with specific sexual or drug-use activities, including those in which the client might not be currently engaged. Negotiate a concrete, achievable behavior-change step that will reduce HIV risk. Although the optimal goal might be to eliminate HIV risk behaviors, small behavior changes can reduce the probability of acquiring or transmitting HIV. Behavioral risk-reduction steps should be acceptable to the client and appropriate to the clients situation. For clients with several high-risk behaviors, the counselor should help clients focus on reducing the most critical risk they are willing to commit to changing. The step does not need to be a personal behavior change. For many clients, knowledge of a partners recent HIV status (and talking with the partner about getting an HIV test) might be more critical than personal behavior changes. The step should be relevant to reducing the clients own HIV risk and should be a small, explicit, and achievable goal, not a global goal (Box 6). Identifying the barriers and supports to achieving a step, through interactive discussion, role-play modeling, recognizing positive social supports, or other methods will enhance the likelihood of success (90 ). Writing down the goal might be useful. For clients with ongoing risk behaviors, referral to additional prevention and support services is encouraged. Seek flexibility in the prevention approach and counseling process. Counselors should avoid a one-size-fits-all prevention message (e.g., always use condoms). Behaviors that are safe for one person might be risky for another (91 ). For example, unprotected vaginal intercourse might be unsafe with anonymous partners whose HIV status is unknown, but safe for uninfected persons in a mutually monogamous relationship. The length of counseling sessions will vary depending on client risk and comfort (e.g., adolescents might require more time than adults). Provide skill-building opportunities. Depending on client needs, the counselor can demonstrate or ask the client to demonstrate problem-solving strategies such as a) communicating safer sex commitments to new or continuing sex partners; b) using male latex condoms properly; c) trying alternative preventive methods (e.g., female condoms); d) cleaning drug-injection equipment if clean syringes are unavailable; or e) communicating safer drug-injection commitments to persons with whom the client shares drug paraphernalia (86,9294 ). Use explicit language when providing test results. Test results should be provided at the beginning of the follow-up session. Counselors should never ask the client to guess the test results. Technical information regarding the test can be provided through a brochure or other means so the session can focus on personal HIV risk reduction for clients with negative tests and other considerations for clients with positive or indeterminate test results (see Additional Counseling Considerations for Special Situations). In-depth, technical discussions of the window period (i.e., the time from when a person is infected until they develop detectable HIV antibody) should be avoided because they could confuse the client and diffuse the
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importance of the HIV prevention message. Counselors should clarify that negative test results do not mean the client has no HIV risk and work with the client to reconsider ongoing HIV risk behaviors and the benefits of taking steps to reduce those risks. A client with ongoing risk behaviors should not be given a false sense of the safety of those behaviors (i.e., avoid statements like whatever you were doing seems to be safe or continue to do whatever you are doing now). These counseling elements are considered necessary for high-quality counseling. Specialists in the field (Technical Expert Panel Review of CDC HIV Counseling, Testing, and Referral Guidelines; February 1819, 1999; Atlanta, Georgia) also suggested adoption of the following: Ensure that the client returns to the same counselor. Consistency of the client and counselor relationship helps the client feel secure, reduces misunderstanding, and promotes the likelihood of effective risk reduction. Effective counseling models tended to use the same counselor for all sessions. When follow-up prevention counseling sessions must be provided by a different counselor, careful recordkeeping is recommended to ensure high-quality counseling. See The Compendium of HIV Prevention Interventions with Evidence of Effectiveness at <http:// www.cdc.gov/hiv/pubs/hivcompendium.pdf>. Use a written protocol to help counselors conduct effective sessions. A structured protocol outlining session goals can help keep the counselor focused on risk reduction. The protocol can include examples of open-ended questions (to help a new counselor avoid closed-ended questions) and a list of explicit risk-reduction steps (to help a new counselor avoid accepting a clients suggestion of global riskreduction steps) (95 ). Ensure ongoing support by supervisors and administrators. Supervisory support is essential for effective counseling. Training in HIV counseling approaches that focus on personal risk reduction is recommended for persons supervising counselors. Staff appraisals should acknowledge that completion of critical counseling elements has higher priority than completion of paperwork. Avoid using counseling sessions for data collection. If required, paperwork should be completed at the end of the counseling session or by staff members who are not counseling. Checklist risk assessments driven by data collection forms are detrimental to effective counseling because they can encourage even skilled counselors to use closed-ended questions, limit eye contact, and miss critical verbal and nonverbal cues. The relevance of any routinely collected data should be periodically assessed. Avoid providing unnecessary information. An emphasis on providing information might prompt counselors to miss critical HIV prevention opportunities and cause clients to lose interest. Discussion of theoretical HIV risks (e.g., sex with a person with hemophilia or needle exposures through tattoos) tends to shift the focus away from the clients actual HIV risk situations to topics that are more comfortable or easy to discuss but irrelevant to the clients risk.
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When a client receives the test result, the provider should ensure that the client understands it. As part of HIV prevention counseling, providers should explicitly discuss and clarify any misconceptions regarding HIV transmission risk to partners associated with specific sexual or needle-sharing activities. Clients should be advised to refrain from donating blood, plasma, or organs. For sexually active clients who are not in mutually monogamous partnerships, providers should also address strategies to prevent other sexually transmitted or bloodborne infections (e.g, gonorrhea, syphilis, chlamydia, herpes simplex virus, human herpes virus type 8 [the virus linked to Kaposi sarcoma], hepatitis B virus, hepatitis C virus, and cytomegalovirus). The first few months after persons learn they are HIV infected are important for accessing medical and other support services to help them obtain treatment and establish and maintain behavior changes that reduce the likelihood of transmitting the virus to others. For example, persons with ongoing risks might be referred for prevention counseling to prevent transmission to others or for prevention case management. For all newly identified clients, a follow-up appointment 36 months after diagnosis is recommended by some specialists (99 ) to assess whether clients were able to initiate medical care, minimize transmission risk to uninfected partners, and access other needed services (e.g., partner counseling and referral services). See guidance on partner counseling and referral services (27 ) and prevention case management (28 ). Persons with a single, recent nonoccupational HIV exposure. After a reported sexual, injection-drug use, or other nonoccupational exposure to HIV (55 ), providers should refer clients for prompt initiation of evaluation, counseling, and follow-up services. Early postexposure prophylaxis could reduce the likelihood of becoming infected with HIV, although the degree to which early treatment can prevent new infection after acute nonoccupational HIV exposure is unclear. Further guidance on nonoccupational HIV exposure is available (55 ). Persons with indeterminate HIV test results. Until follow-up test results are available, persons with an indeterminate result should receive information regarding the meaning of test results. HIV prevention counseling should be the same as for a person with newly identified HIV infection. Behaviors that minimize the risk for HIV transmission to sex and needle-sharing partners should be emphasized, even if the client reports no risk behaviors. Clients with repeated indeterminate test results >1 month apart are unlikely to be HIV-infected and can be provided test results in the same way as clients with negative test results, unless recent HIV exposure is suspected (see Indeterminate Test Results). Persons seeking repeat HIV testing. In addition to brief prevention counseling sessions, ongoing HIV prevention counseling aimed at personal risk reduction might be useful for persons seeking repeated HIV testing who have continued HIV risk. Counselors should encourage clients to explore alternative prevention strategies and to identify and commit to additional risk-reduction steps. Clients with ongoing risk behaviors might benefit from referral to other HIV prevention and support services because their current risk behavior might be reinforced by repeated negative HIV test results or they might view HIV testing as protective (100 ). More information on prevention case management is available (28 ) (see Ongoing Exposure).
MMWR
23
Persons who use drugs. Persons who inject drugs might also be at increased risk for acquiring HIV through unprotected sex with an HIV-infected partner (101103 ). For injection-drug users (IDUs), intervention studies indicate that personalized, interactive prevention counseling models using goal-setting strategies might be effective in reducing injection-drug and sexual-risk behaviors (3941,84 ). Evidence also supports the efficacy of community strategies (e.g., methadone maintenance programs or other drug treatment programs, outreach programs, and syringe exchange) to reduce new HIV infections among IDUs (104108 ). Specialists in the field advocate recommending such strategies, along with individual HIV prevention counseling, to persons who inject drugs. Sex or needle-sharing partners of HIV-infected persons. Sex or needle-sharing partners of HIV-infected persons should be encouraged to have HIV prevention counseling and testing. Partners who are HIV discordant (i.e., one person is HIVinfected and the other is uninfected) should receive counseling aimed at preventing HIV transmission from the infected to the uninfected partner, including explicit discussion and clarification of any misconceptions regarding HIV transmission risk associated with specific sexual or needle-sharing activities. In addition, many HIV-discordant couples benefit from ongoing HIV prevention counseling aimed at personal risk reduction or from couples counseling that teaches safe sexual practices and proper condom use (27,109111 ). Little evidence exists to conclusively support or refute whether simultaneous infection with >2 subtypes of HIV is likely to occur or, if it does, whether it is associated with more aggressive or resistant disease (112 ). Researchers are divided on the value of recommending consistent condom use to prevent HIV sequelae for mutually monogamous, HIV-infected partners. Health-care workers after an occupational exposure. After an occupational exposure, health-care workers should use measures to prevent transmission during the follow-up period (54 ). HIV-exposed health-care workers should be advised that, although HIV is infrequently transmitted through an occupational exposure, they should abstain from sex or use condoms and avoid pregnancy until they receive a negative follow-up test result. In addition, they should not donate blood, plasma, organs, tissue, or semen; if a woman is breast-feeding, she should consider discontinuing (54 ). Health-care workers should also be advised of the rationale for postexposure prophylaxis, the risk for occupationally acquired HIV infection from the exposure, the limitations of current knowledge of the efficacy of antiretroviral therapy when used as postexposure prophylaxis, the toxicity of the drugs involved, and the need for postexposure follow-up (including HIV testing), regardless of whether antiretroviral therapy is taken. Further guidance on occupational HIV exposure is available (54 ). Participants in HIV vaccine trials. HIV-vaccineinduced antibodies may be detected by current HIV tests and may cause a false-positive result. Trial participants should be advised that HIV CTR is best provided at the vaccine trial sites, the vaccine is of unknown efficacy, and HIV risk behavior can result in their becoming HIV-infected (see Positive Test Results).
24
MMWR
November 9, 2001
MMWR
25
Thus, face-to-face prevention counseling is preferred for clients at increased HIV risk. Most HIV test sites use an enzyme immunoassay (EIA) and confirmatory test algorithm that requires several days for final results. The return visit for test result offers an opportunity to continue prevention counseling in a second, face-to-face meeting. However, in some settings (e.g., STD clinics, managed care organizations, and other private settings), many clients do not return for their results (50,114116 ). In such settings, providers can adopt strategies that increase clients receipt of test results, and counseling strategies might need to be adapted (117 ). Telephone Counseling. Limited studies among STD clinic clients at lower risk indicated that substantially more clients learned their HIV infection status when negative test results were provided by telephone rather than in person (12,117,118 ). Although home sample collection provides a precedent for providing counseling by telephone to persons with either negative or positive HIV test results, the efficacy of telephone counseling in reducing HIV risk behaviors or the number of new HIV infections has not been studied. One study indicated that telephone notification of positive results was associated with delay in linkage to care (119 ). However, not learning positive test results at all guarantees a delay in linkage to care. Many specialists recommend that provision of HIV test results and prevention counseling by telephone be limited to clients whose results are negative (Technical Expert Panel Review of CDC HIV Counseling, Testing, and Referral Guidelines; February 1819, 1999; Atlanta, Georgia). Also, given the known riskreduction benefits of face-to-face counseling, lack of efficacy data on telephone counseling, and concerns regarding disinhibition (e.g., since my test result is negative, whatever risks I am taking now may be okay), telephone counseling should be limited to clients without known ongoing HIV risk behaviors (e.g., unprotected sex or needlesharing with an HIV-infected [or status unknown] partner). Single-Session Prevention Counseling with Rapid Testing. Rapid tests allow clients to receive their HIV test results the same day. This process could reduce the number of clients receiving two prevention counseling sessions. Studies of the efficacy of single HIV prevention counseling sessions for use with a rapid test are under way. Although some single-session counseling protocols have been successfully implemented in busy clinics and are well-accepted by most clients, how well a single counseling session reduces risk behaviors or the number of new HIV infections is unknown. A counseling protocol for use with a rapid test is being studied; information is available at <http://www.cdc.gov/hiv/ projects/respect-2>. For clients with identified risk behaviors, referral or rescheduling for ongoing counseling should be considered.
26
MMWR
November 9, 2001
Training and continuing education. Basic training in the use of >1 of the interactive HIV prevention counseling models aimed at personal risk reduction is recommended for counselors and supervisors. Counselors should know the communities they serve and the available referral opportunities. They also might benefit from formal training on a) transmission and prevention of HIV and other sexually transmitted and bloodborne diseases, b) the natural history of HIV, c) recognition and treatment of opportunistic infections, d) new therapeutic agents used to treat HIV and AIDS, e) PCRS, f) prevention case management, and g) other HIV prevention and support services available in the community (e.g., services related to substance abuse assessment, cultural competence, adolescent concerns, domestic abuse, and health concerns for gay or lesbian clients). Additional training in specific counseling skills is also warranted (e.g., training on how to facilitate groups for counselors conducting group sessions). For training opportunities, providers or supervisors can contact their state health departments HIV/AIDS program office. Supervisor observation and immediate feedback to counselors. Direct observation of counseling sessions can help ensure that objectives are being met (80 ). Supervisors can perform this task periodically (with client consent). Sessions might also be audiotaped (with client consent), or counseling can be demonstrated through role-play scenarios between the counselor and supervisor. Observation and feedback should be structured, and the outcome should be constructive, not punitive. Supervisors should support positive elements of the prevention counseling session and provide specific, constructive comments regarding content areas needing improvement. Observation and feedback should be conducted regularly for routine counseling. Staff discomfort with observation typically wanes over time; many counselors report that the sessions are useful in enhancing skills. When observation is offered routinely, clients seldom refuse to participate. A suggested time frame for routine, direct observation of an HIV prevention counselor by the supervisor is twice monthly for the first 6 months, monthly for the second 6 months, and quarterly for counselors with >1 year of experience. After observation, supervisors should provide feedback to counselors quickly, preferably the same week. Observation and feedback forms used in research studies of client-centered HIV prevention counseling are available at <http:// www.cdc.gov/hiv/projects/RESPECT/default.htm>. Periodic evaluation of physical space, client flow, and time concerns. Counseling sessions should be conducted in a private space where discussion cannot be overheard. Clients should not wait for long periods between testing and counseling, and information could be provided during waiting times (e.g., through videos). Periodic time-flow analyses or client surveys can be used to evaluate adequacy of space, client flow, and length of waiting period. Periodic counselor or client satisfaction evaluations. Evaluations of client satisfaction can ensure that counseling meets client needs. These evaluations also can provide important feedback to counselors who otherwise might not see the benefits of what they do. Evaluations can be brief. Surveys should address whether specific counseling goals were met, the type of interaction (e.g.,who talked more, the counselor or the client?), and, when applicable, specifics of
MMWR
27
development of the risk-reduction plan (e.g, what was the behavior change step that you agreed to work on?). Linking client and counselor descriptions of a particular session might be useful. Conducting such evaluations only occasionally (e.g., for 12 weeks once or twice a year) decreases the programmatic burden and is probably sufficient to identify problems. For more information, see Quality Assurance and Evaluation of HIV CTR Services. Case conferences. Regularly scheduled meetings of counselors allow supervisors to understand counselors skills and areas that need improvement and can help counselors learn techniques from their colleagues. Case conferences are an opportunity for counselors to discuss specific or problematic questions asked by clients, allowing providers to better understand the concerns facing clients who are HIV-infected or at increased risk for HIV. Case conferences can help offset counselor fatigue and burn out by providing a positive outlet for dealing with difficult situations. Discussion might focus on a hard-to-address client or specific elements (e.g., developing acceptable and practical risk-reduction plans with clients who deny the magnitude of their HIV risk). Frequency of case conferences should be balanced with client volume, with efforts made to meet at least monthly.
TABLE. Performance attributes and potential applications of HIV test technologies approved by the U.S. Food and Drug Administration (FDA) for diagnostic use
Specimen (mode of collection) Serum or plasma (phlebotomy) Test complexity* High Screening; confirmatory Enzyme immunoassay (EIA); Western blot or immunofluorescence assay (IFA) Strains detected HIV-1 and HIV-2 Provision of results HIV negative: Test result at return visit (typically a few days to 12 weeks) HIV positive: Confirmed result at return visit
28
Advantages High sensitivity Rare falsepositives High-volume processing Utility for testing for other conditions (e.g., sexually transmitted diseases [STDs]) Convenience Increased receipt of test results Use in urgent medical circumstances (e.g., postexposure prophylaxis)
Rapid test
Moderate
HIV-1
HIV negative: Test result at time of testing (typically 1060 minutes) HIV positive: Preliminary positive test result at time of testing;** confirmed result at return visit
Settings with low return rates Perinatal/labor and delivery for prophylaxis Health-care settings for decisions regarding postexposure prophylaxis Outreach settings Community-based settings Syringe exchange programs Rural areas Settings serving clients not at increased risk Home
MMWR
High
HIV-1
HIV negative: Test result when client telephones (typically 37 days) HIV positive: Confirmed result when client telephones
November 9, 2001
TABLE. (Continued ) Performance attributes and potential applications of HIV test technologies approved by the U.S. Food and Drug Administration (FDA) for diagnostic use
Specimen (mode of collection) Oral mucosal transudate (oral fluid collection device) Test complexity* High Screening; confirmatory EIA; Oral mucosal transudate Western blot Strains detected HIV-1 Provision of results HIV negative: Test result at return visit (typically 12 weeks) HIV positive: Confirmed result at return visit
Advantages Noninvasive Nontechnical collection No venipuncture Decreased infectious hazard Utility in nonclinical settings
Potential settings Outreach settings Community-based settings Syringe exchange programs Drug treatment centers Adolescent and school-based clinics and university health centers Outreach settings Community-based settings Syringe exchange programs Drug treatment centers Adolescent and school-based clinics and university health centers
Urine-based test
High
HIV-1
HIV negative: Test result at return visit (typically 12 weeks) HIV positive: Test result at return visit; further confirmation by blood sample recommended because of lower specificity of urine Western blot compared with serumbased Western blot/IFA
Noninvasive Nontechnical collection No venipuncture Decreased infectious hazard Utility in nonclinical settings Utility for testing for other conditions (e.g., STDs)
MMWR 29
* Complexity of specimen collection and testing as categorized by the Clinical Laboratory Improvement Amendments (CLIA). (Schochetman G, George JR, eds. AIDS testing: a comprehensive guide to technical, medical, social, legal, and management issues. 2 ed. New York, NY: Springer-Verlag, 1994.) All licensed enzyme immunoassays (EIAs) detect HIV-1, but not all detect HIV-2. EIAs that can detect HIV-1 and HIV-2 are required for blood donor screening and are recommended for diagnostic screening only where HIV-2 infection is likely. No licensed confirmatory test exists for HIV-2. Although current tests detect most HIV-1 group O infections, few detect all such infections. The one rapid test licensed by FDA, Abbott Murex Single Use Diagnostic System (SUDS) HIV-1 test (Abbott Laboratories, Inc., Abbott Park, Illinois) is classified as a moderate-complexity test and requires on-site laboratory testing capability. Future rapid tests could be classified by CLIA as waived and not require on-site laboratory testing capability, depending on the expertise required to perform the test correctly. Future rapid tests might be able to be confirmed with a second rapid test to provide an immediate test result with high sensitivity, specificity, and predictive value comparable with EIA/Western blot (Stetler HC, Granade TC, Nunez CA, et al. Field evaluation of rapid HIV serologic tests for screening and confirming HIV-1 infection in Honduras. AIDS 1997;11:36975). ** Information on providing preliminary positive test results from a single rapid test is available elsewhere (CDC. Update: HIV counseling and testing using rapid testsUnited States, 1995. MMWR 1998;47:2115). Home sample collection is different from home-use testing. FDA has approved home sample collection, but not home-use HIV test kits (Kassler WJ. Advances in HIV testing technology and their potential impact on prevention. AIDS Educ Prev 1997;9[suppl B]:2740).
30
MMWR
November 9, 2001
complexity of laboratory services required for the test, availability of trained personnel, and FDA approval of the test.
MMWR
31
occurred. Specimens with a reactive EIA result are retested in duplicate. If the result of either duplicate test is reactive, the specimen is reported as repeatedly reactive and undergoes confirmatory testing with a more specific supplemental test (e.g., Western blot or, less commonly, an immunofluorescence assay [IFA]). Only specimens that are repeatedly reactive by EIA and positive by IFA or reactive by Western blot are considered HIV-positive and indicative of HIV infection. Specimens that are repeatedly EIAreactive occasionally provide an indeterminate Western blot result, which might represent either an incomplete antibody response to HIV in specimens from infected persons or nonspecific reactions in specimens from uninfected persons (127 ). Although IFA can be used to resolve an indeterminate Western blot sample, this assay is not widely used. Generally, a second specimen should be collected >1 month later and retested for persons with indeterminate Western blot results. Although much less commonly available, nucleic acid testing (e.g., viral RNA or proviral DNA amplification method) could also help resolve an initial indeterminate Western blot in certain situations. A small number of tested specimens might provide inconclusive results because of insufficient quantity of specimen for the screening or confirmatory tests. In these situations, a second specimen should be collected and tested for HIV infection.
32
MMWR
November 9, 2001
MMWR
33
the provider by telephone to receive negative HIV results might increase rates of receipt of results, satisfy client preferences for options, and preserve setting resources without apparent adverse consequences (52,117,118 ). Although no published research exists regarding use of telephones for providing positive HIV test results with most HIV test technologies, limited experience exists on using this method to provide HIV-positive test results for home sample collection testing (52 ).
Providing Test Results During the Initial Visit Through Rapid Tests
More clients receive their HIV test results with rapid tests because results can be provided at the testing visit (120 ). Rapid test technology could be useful in urgent medical circumstances (e.g., when decisions must be made regarding postexposure prophylaxis) and in nontraditional settings with low return rates (e.g., community-based or outreach settings). During the initial visit, the provider can definitively tell clients who have had a single rapid HIV test with negative results that they are not infected (120 ), except when retesting might be indicated because of recent known or possible exposure to HIV. A reactive rapid HIV test result should be considered preliminary until the completion of confirmatory testing, and results should be carefully communicated to the client because of the possibility of a false-positive result. The likelihood that a positive screening test truly indicates the presence of HIV infection decreases as HIV prevalence in the tested population becomes lower. Therefore, false-positive HIV test results are more likely in settings where the tested population prevalence is lower than in settings where the tested population prevalence is higher. When a preliminary, positive rapid test is explained to clients, phrases like a good chance of being infected or very likely infected can be used to indicate the likelihood of HIV infection and qualified based on the HIV prevalence in the setting and the clients individual risk (120 ). Further testing is always required to confirm a reactive screening test result.
34
MMWR
November 9, 2001
Recent Exposure
Follow-up testing might be appropriate for clients who have negative test results but who have not had time to develop detectable antibody after a recent documented occupational (54 ) or nonoccupational (sexual or needle-sharing) (55 ) exposure to HIVinfected persons or persons at increased risk for HIV with unknown HIV status. The timing of follow-up testing should provide assurance that the exposure did not lead to infection. Follow-up testing should be conducted in a timely manner so clients identified as HIVinfected can receive appropriate antiretroviral treatment and prevention and support services as soon as possible.
Ongoing Exposure
Persons with continued HIV risk behavior pose a special challenge for follow-up testing. In some settings, clients with ongoing risk represent a substantial proportion of those receiving HIV CTR. In most circumstances, follow-up HIV testing should be recommended periodically for clients with ongoing risk behavior. Follow-up testing would monitor the clients HIV status, but also promote continued client contact, opportunities for HIV prevention counseling (see Additional Counseling Considerations for Special Situations), and referral to additional preventive and support services.
No Identifiable Risk
In general, persons with no recent identifiable risk for HIV infection should receive additional HIV prevention counseling and follow-up testing when requested. Efforts should be made to understand why these clients repeatedly seek follow-up testing. These clients should be considered for in-depth prevention counseling and referral to support services, where appropriate.
Special Considerations
General recommendations for follow-up testing might not be applicable in all circumstances. In certain circumstances (e.g., when persons are simultaneously exposed to hepatitis C virus and HIV [54 ] and when persons have received HIV vaccines), guidance should be provided only after consultation with specialists.
MMWR
35
36
MMWR
November 9, 2001
MMWR
37
guidelines (see Revised Recommendations for HIV Screening of Pregnant Women ). Drug or alcohol prevention and treatment. Clients who abuse drugs or alcohol should receive or be referred to substance or alcohol abuse prevention and treatment services. Mental health services. Clients who have mental illness, developmental disability, or difficulty coping with HIV diagnosis or HIV-related conditions should receive or be referred to appropriate mental health services. Legal services. Clients who test positive should be referred to legal services as soon as possible after learning their test result for counseling on how to prevent discrimination in employment, housing, and public accommodation by only disclosing their status to those who have a legal need to know. STD screening and care. Clients who are HIV-infected or at increased risk for HIV are at risk for other STDs and should receive or be referred for STD screening and treatment (146 ). Screening and treatment for viral hepatitis. Many clients who are HIV-infected or at increased risk for HIV are at increased risk for acquiring viral hepatitis (A, B, and C). Men who have sex with men and IDUs should be vaccinated for hepatitis A. All clients without a history of hepatitis B infection or vaccination should be tested for hepatitis B, and if not infected, should receive or be referred for hepatitis B vaccination. In addition, clients who inject drugs should be routinely recommended testing for hepatitis C. All clients who are infected with hepatitis viruses should be referred for appropriate treatment. Further guidance is available (30,32 ). Other services. Clients might have multiple needs that can be addressed through other HIV prevention and support services (e.g., assistance with housing, food, employment, transportation, child care, domestic violence, and legal services). Addressing these needs can help clients access and accept medical services and adopt and maintain behaviors to reduce risk for HIV transmission and acquisition. Clients should receive referrals as appropriate for identified needs.
38
MMWR
November 9, 2001
on ensuring that HIV-infected clients are assessed for referral needs related to medical care, PCRS, and prevention and support services aimed at reducing the risk for further transmission of HIV. When a provider cannot make appropriate referrals or when client needs are complex, clients should be referred to a case management system.
MMWR
39
and education should address resources available and methods for managing referrals, as well as promote understanding of factors likely to influence the clients ability and willingness to use a referral service (e.g., readiness to accept the service, competing priorities, financial resources). Referrals are more likely to be completed when a provider is able to correctly evaluate a clients readiness to adopt risk-reducing behaviors (147 ). Research has indicated that cross-training increases knowledge and understanding of community resources among providers and can indicate gaps in services (148 ). Authority. Staff members providing referrals must have the authority necessary to accomplish a referral. Supervisors must ensure that staff members understand referral policy and protocol and have the necessary support to provide referrals. This requires the authority of one provider to refer to another (e.g., through memoranda of agreement) or to obtain client consent for release of medical or other personal information. Advocacy. Staff members who negotiate referrals must possess knowledge and skills to advocate for clients. Such advocacy can help clients obtain services by mediating barriers to access to services and promoting an environment in which providers are better informed regarding the needs and priorities of their clients.
Referral Resources
Knowledge of available support services is essential for successful referrals. When referral resources are not available locally, providers should identify appropriate resources and link clients with them. A resource guide should be developed and maintained to help staff members make appropriate referrals (Box 7). Information regarding community resources can be obtained from local health planning councils, consortia, and community planning groups. Local, state, and national HIV/AIDS information hotlines or websites (e.g., NPIN), community-based health and human service providers, and state and local public health departments can also provide information.
40
MMWR
November 9, 2001
BOX 7. Contents of a referral resource guide For each resource, the referral resource guide should specify the following: Name of the provider or agency Range of services provided Target population Service area(s) Contact names and telephone and fax numbers, street addresses, e-mail addresses Hours of operation Location Competence in providing services appropriate to the clients culture, language, sex, sexual orientation, age, and developmental level Cost for services and acceptable methods of payment Eligibility Application materials Admission policies and procedures Directions, transportation information, and accessibility to public transportation Client satisfaction with services
advantage of them. Expanding CTR into nontraditional settings can be accomplished through partnership with community-based service providers and use of new, FDAapproved HIV test technologies that offer portability, less-invasive sample collection, less-complex sample collection and processing, and reduced biohazard. To ensure effective CTR that is responsive to client needs, providers should develop and implement written quality assurance protocols and procedures specifically for services provided in nontraditional settings.
MMWR
41
Mark a specific room with a do not disturb or occupied sign. Designate an area in the setting that provides physical privacy. In parks and similar locations, seek areas with as much privacy as possible. Provide counseling and testing services in the clients home or other secure setting. Have clients return to the setting to receive test results and counseling and referral.
Informed Consent
Staff members providing CTR services should be sensitive to barriers that can interfere with obtaining true informed consent, including alcohol and drug use, mental illness, and peer pressure in venues where persons congregate or socialize. Suggested strategies for obtaining informed consent in nontraditional settings include the following: Schedule an appointment to test at a later date/time. Follow up at a later time with the client if contact information is available. Read the informed consent form to the client. Use verbal prompts to ensure that the client understands information in the informed consent form.
Counseling
Staff members working in community-based and other nontraditional settings should know and use risk-screening strategies to determine whether HIV prevention counseling should be recommended. Staff members should be trained in HIV prevention counseling or other approaches aimed at personal HIV risk reduction. When appropriate (e.g., among IDUs), information regarding other STDs and bloodborne diseases should be incorporated into the counseling sessions (29,30 ).
Testing
The decision to offer HIV testing in nontraditional settings should be based on several factors, including availability of resources and feasibility of providing test results and follow-up. In some cases, referral to other providers is appropriate. The selection of a specific HIV test technology should be based on logistical issues (e.g., field conditions related to collection, transport, and storage of specimens; worker safety; and the likelihood that clients will receive HIV test results). Providers must understand the extent to which field conditions can affect specimens (e.g., extreme temperatures or time lapse from collection to processing). Test specimens should be collected, stored, and transported according to manufacturer instructions.
42
MMWR
November 9, 2001
Provide a telephone number that clients can call to receive test results. Make an appointment with the client at the time of testing to receive results. Provide incentives (e.g., food certificates, hygiene kits, food). Return to a site on a regularly scheduled basis. Provide reminders when contact information is available.
Referral
Staff members working in community-based and outreach settings should be trained to implement and manage referrals. Providers should establish appropriate collaborative relationships for referrals. Arranging for PCRS staff members or case managers to be available to clients at the time test results are provided might help promote referral.
Record Keeping
Maintaining the confidentiality of client records is critical. Providers should develop written protocols for record keeping that address transport of client records to and from outreach venues. Strategies to maintain confidentiality of client records in nontraditional settings include the following: Return all client records to the office immediately after the CTR session. Use codes or unique identifiers rather than client names. Store all records in a secured area (e.g., locked file drawers). Provide option of anonymous counseling and testing as well as confidential counseling and testing. Verify identity of client (e.g., match client signature with that provided for informed consent or check identification card) when providing test results. Store paperwork in a lockbox while in outreach settings. Password protect and encrypt electronically stored client records. Where allowed by state/local statute, clients can choose anonymous HIV testing. Procedures to ensure client anonymity (i.e., no indication of testing in the clients record and no recording of personal identifying information on laboratory requests) should be developed. Even when staff members providing CTR services know the client (including name and locating information) from other activities, the clients right to be tested anonymously should be protected.
Staff Safety
Providing services in outreach settings (e.g., bars, parks) might compromise staff safety, which must be considered in development of outreach protocols. Appropriate training and precautions (e.g., working in teams) should be developed in planning services in nontraditional settings.
MMWR
43
Evaluation
CTR services should be continually evaluated to improve services to clients and provide accountability to stakeholders (150,151 ). Evaluation should be interactive, involving individual persons and organizations affected by the services (150 ). In public health settings, the community goals outlined in community health planning processes and other relevant local planning processes could be incorporated. Providers should identify the key, relevant program goals and objectives that reflect services to the program, community, and client, and then determine what data are needed to evaluate those goals and objectives. Information obtained from the evaluation should be used to plan and prioritize provision of CTR services within a setting. For example, information from the HIV Counseling and Testing System (133 ) or locally available
44
MMWR
November 9, 2001
sources could be used during local community planning (e.g., HIV prevention community planning) to help develop or revise an HIV/AIDS prevention plan or describe who needs services. If resources for evaluation are limited, comprehensive evaluations (e.g., examining outcome or impact) might not be possible. However, even with limited resources, providers can conduct meaningful evaluations by focusing on relevant local outcomes (82 ).
Data
Data collected should have a clear, anticipated use and should not be the focus of or interfere with provision of CTR services. Data should be used to evaluate the extent to which the goals of CTR and locally defined service outcomes (e.g., targeted return rates, knowledge of HIV infection status, proportion of successful referrals) are met. Although sound data are essential for evaluation of services, the primary purpose of each visit should be to provide the best possible service to the client. Data should be recorded outside the time reserved for CTR discussions between the provider and the client. Clients could complete a questionnaire or intake information form on admission, providers could complete the forms immediately after meeting with a client, or a combination of the two approaches could be used. Data collection methods should be compatible with the evaluation needs and priorities of the CTR setting and locally defined service outcomes. Data should be collected with a standard collection instrument throughout the program. Simple data collection instruments (e.g., intake forms, medical record reviews) should be developed so data can be collected unobtrusively as part of the provision of services. Publicly funded CTR sites collect data on client demographic characteristics, risk behavior/exposure category, test acceptance, and type of site where service is provided (133 ). Most sites record the date of visit, anonymous or confidential test status, previous test result, current test result, and return for current test result for each client encounter. Additional data can be useful for evaluation of services, including date of previous test, type of current test (e.g., standard, rapid, oral fluid), risk-reduction plan summary, information relevant to any referrals made (e.g., provider and service description, information and materials provided, whether an appointment was made), whether the referral was received, type of service provided, dates when services were provided, and other relevant information (e.g., follow-up required, additional service needs).
Confidentiality
Any data collected or recorded must be collected or recorded in a manner that ensures the confidentiality of the client. Clear procedures and protocol manuals must be developed and used.
MMWR
45
Adequate training in the use of data collection instruments should be provided to all staff members to ensure that the evaluation process is not interfering with the provision of high-quality CTR services. The information assembled during the evaluation process should be analyzed and reported in a timely manner to individual persons and organizations affected by the service. Information and feedback gained during the evaluation process should be used to improve the services offered by the site to the client.
CONCLUSION
Advances in HIV prevention and medical treatment increase the importance of HIV CTR services. Prevention counseling and knowledge of HIV status can help persons who are HIV-infected or at increased risk for HIV infection reduce their risk for transmitting or acquiring HIV infection. Referral can help persons access relevant medical, preventive, and psychosocial support services to reduce their risk for transmitting or acquiring HIV infection. These guidelines recommend how CTR can be provided to clients who could most benefit from these services across various settings and client populations.
ADDITIONAL RESOURCES
Additional information on HIV CTR can be obtained from the following sources: CDCs National Center for HIV, STD, and TB Prevention website at <http:// www.cdc.gov/nchstp/od/nchstp.html>. CDC National AIDS Hotline in English, (800) 342-2437. CDC National AIDS Hotline in Spanish, (800) 344-7432. CDC National AIDS Hotline TTY, (800) 243-7889. CDC National STD Hotline, (800) 227-8922. CDCs National Prevention Information Network at <http://www.cdcnpin.org> or (800) 458-5231 (information available in English and Spanish). HIV/AIDS Treatment Information Service at <http://www.hivatis.org> or (800) 4480440 (information available in English and Spanish). AIDS Clinical Trials Information Service at <http://www.actis.org> or (800) 8742572 (information available in English and Spanish). National Clinicians Post-Exposure Prophylaxis Hotline at <http://pepline.ucsf.edu/ PEPline> or (888) 448-4911.
Acknowledgments We are grateful for the contributions of health professionals within CDC and elsewhere (e.g., Health Resources and Services Administration, National Alliance of State and Territorial AIDS Directors, academic institutions, health departments, health-care organizations). We also thank graduate students/research assistants Jennifer Chapman, M.P.H., Steven J. Connor, M.P.H., and Parag R. Sanghvi, M.S.P.H., National Center for HIV, STD, and TB Prevention, CDC.
46
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83. Kamb ML, Kassler W, Peterman TA, and the Project RESPECT Study Group. Cost of preventing HIV via counseling: results from a randomized trial (Project RESPECT) [Abstract 33263]. Presented at the XII International Conference on AIDS, Geneva, Switzerland, 1998:644. 84. Booth RE, Kwiatkowski CF, Stephens RC. Effectiveness of HIV/AIDS interventions on drug use and needle risk behaviors for out-of-treatment injection drug users. J Psychoactive Drugs 1998;30:26978. 85. Castrucci BC, Kamb ML, Hunt K. Assessing use of the 1994 HIV counseling, testing, and referral standards and guidelines how closely does practice conform to existing recommendations? [Abstract P125]. Presented at the 2000 National STD Prevention Conference, December 47, Milwaukee, WI, 2000. 86. Kelly JA, Murphy DA, Sikkema KJ, Kalichman SC. Psychological interventions to prevent HIV infection are urgently needed: new priorities for behavioral research in the second decade of AIDS. Am Psychol 1993;48:102334. 87. McCusker J, Stoddard AM, Zapka JG, Zorn M, Mayer KH. Predictors of AIDS-preventive behavior among homosexually active men: a longitudinal study. AIDS 1989;3:4438. 88. Kelly JA, Murphy DA. Some lessons learned about risk reduction after ten years of the HIV/AIDS epidemic. AIDS Care 1991;3:2517. 89. Kelly JA, Murphy DA. Psychological interventions with AIDS and HIV: prevention and treatment. J Consult Clin Psychol 1992;60:57685. 90. American Public Health Association. AIDS prevention in the community: lessons from the first decade. Washington, DC: American Public Health Association, 1995. 91. Wiktor SZ, Biggar RJ, Melbye M, et al. Effect of knowledge of human immunodeficiency virus infection status on sexual activity among homosexual men. J Acquir Immune Defic Syndr 1990;3:628. 92. Kelly JA, St. Lawrence JS, Betts R, Brasfield TL, Hood HV. A skills-training group intervention model to assist persons in reducing risk behaviors for HIV infection. AIDS Educ Prev 1990;2:2435. 93. Sikkema KJ, Winett RA, Lombard DN. Development and evaluation of an HIV-risk reduction program for female college students. AIDS Educ Prev 1995;7:14559. 94. Kelly JA, Kalichman SC. Increased attention to human sexuality can improve HIV-AIDS prevention efforts: key research issues and directions. J Consult Clin Psychol 1995;63:90718. 95. CDC. Compendium of HIV prevention interventions with evidence of effectiveness. Atlanta, GA: US Department of Health and Human Services, CDC, 1999. 96. Higgins DL, Galavotti C, OReilly KR, et al. Evidence for the effects of HIV antibody counseling and testing on risk behaviors. JAMA 1991;266:241929. 97. Wolitski RJ, MacGowan RJ, Higgins DL, Jorgenson CM. The effects of HIV counseling and testing on risk-related practices and help-seeking behavior. AIDS Educ Prev 1997;9(suppl B):5267. 98. Flaskerud JH. Matching client and therapist ethnicity, language, and gender: a review of research. Issues in Mental Health Nursing 1990;11:32136. 99. Kilmarx PH, Hamers FF, Peterman TA. Living with HIV: experiences and perspectives of HIV-infected sexually transmitted disease clinic patients after posttest counseling. Sex Transm Dis 1998;25:2837. 100. Cates W, Handsfield HH. HIV counseling and testing: does it work? Am J Public Health 1988;78:15334. 101. Calsyn DA, Saxon AJ, Freeman G, Whittaker S. Ineffectiveness of AIDS education and HIV antibody testing in reducing high risk behaviors among injection drug users. Am J Public Health 1992;82:5735. 102. Edlin BR, Irwin KL, Faruque S, et al. Intersecting epidemicscrack cocaine use and HIV infection among inner-city young adults. N Eng J Med 1994;331:14227.
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103. Cottler LB, Leukefeld C, Hoffman J, et al. Effectiveness of HIV risk reduction initiatives among out-of-treatment non-injection drug users. J Psychoactive Drugs 1998;30:27990. 104. Nicolosi A, Molinari S, Musicco M, Saracco A, Ziliani N, Lazzarin A. Positive modification of injecting behavior among intravenous heroin users from Milan and Northern Italy 19871989. Brit J Addiction 1991;86:91102. 105. Neaigus A, Sufian M, Friedman S, et al. Effects of outreach intervention on risk reduction among intravenous drug users. AIDS Educ Prev 1990;2:25371. 106. Obermeyer TE, Streeter A. Street outreach HIV education to intravenous drug users and other substance abusers. AIDS Patient Care 1991;5:3124. 107. Hagan H, Jarlais DC, Friedman SR, Purchase D, Alter MJ. Reduced risk of hepatitis B and hepatitis C among injection drug users in the Tacoma Syringe Exchange Program. Am J Public Health 1995;85:15317. 108. Jones TS, Vlahov D. Use of sterile syringes and aseptic drug preparation are important components of HIV prevention among injection drug users. J Acquir Immune Defic Syndr 1998;18(suppl 1):S1S5. 109. Padian NS, O Brien TR, Chang Y, Glass S, Francis DP. Prevention of heterosexual transmission of human immunodeficiency virus through couple counseling. J Acquir Immune Defic Syndr 1993;6:10438. 110. Kamenga M, Ryder RW, Jingu M, et al. Evidence of marked sexual behavior change associated with low HIV-1 seroconversion in 149 married couples with discordant HIV-1 serostatus: experience at an HIV counselling center in Zaire. AIDS 1991;5:617. 111. De Vincenzi I. A longitudinal study of human immunodeficiency virus transmission by heterosexual partners. N Eng J Med 1994;331:3416. 112. Levy J, Fox S, Valle M. What you dont know can hurt you: the influence of prior HIV testing on serostatus results at repeat testing [Abstract 43113]. Presented at the 12th World AIDS Conference, Geneva, Switzerland, 1998:869. 113. Irwin KL, Valdiserri RO, Holmberg SD. The acceptability of voluntary HIV antibody testing in the United States: a decade of lessons learned. AIDS 1996;10:170717. 114. Valdiserri RO, Moore M, Gerber AR, Campbell CH Jr, Dillon BA, West GR. A study of clients returning for counseling after HIV testing: implications for improving rates of return. Public Health Rep 1993;108:128. 115. Catania JA, Gibson DR, Marin B, Coates TJ, Greenblatt RM. Response bias in assessing sexual behaviors relevant to HIV transmission. Evaluation and Program Planning 1990;13:1929. 116. Weber JT, Frey R Jr, Horsley R, Gwinn ML. Publicly funded HIV counseling and testing in the United States, 19921995. AIDS Educ Prev 1997;9(suppl B):7991. 117. Branson B, Ballenger A, Olthoff G. HIV test results and post-test counseling by telephone [Abstract PC0535]. Presented at the Tenth International Conference on AIDS, 1994. 118. Schluter WW, Judson FN, Baron AE, McGill WL, Marine WM, Douglas JM Jr. Usefulness of human immunodeficiency virus post-test counseling by telephone for low-risk clients of an urban sexually transmitted diseases clinic. Sex Transm Dis 1996;23:1907. 119. Samet JH, Freedberg KA, Stein MD, et al. Trillion virion delay: time from testing positive for HIV to prevention for primary care. Arch Intern Med 1998;158:73440. 120. CDC. Update: HIV counseling and testing using rapid testsUnited States, 1995. MMWR 1998;47:2115. 121. Federal Trade Commission. Home-use tests for HIV can be inaccurate, FTC warns [Consumer Alert]. 1999. Available at <http://www.ftc.gov/bcp/conline/pubs/alerts/ hivalrt.htm>. Accessed July 13, 2001. 122. CDC. Identification of HIV-1 group O infectionLos Angeles County, California, 1996. MMWR 1996;45:5615. 123. Sullivan PS, Do AN, Robbins K, et al. Surveillance for variant strains of HIV: subtype G and group O HIV-1 [Letter]. JAMA 1997;278:292.
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124. CDC. Human immunodeficiency virus type 2. Atlanta, GA: US Department of Health and Human Services, CDC, 1998. Available at <http://www.cdc.gov/hiv/pubs/facts/hiv2.htm>. Accessed July 4, 2001. 125. CDC. Testing for antibodies to human immunodeficiency virus type 2 in the United States. MMWR 1992;41(No. RR-12):19. 126. CDC. U.S. Public Health Service guidelines for testing and counseling of blood and plasma donors for human immunodeficiency virus type 1 antigen. MMWR 1996;45(No. RR-2):19. 127. Celum CL, Coombs RW, Lafferty W, et al. Indeterminate human immunodeficiency virus type 1 Western blots: seroconversion risk, specificity of supplemental tests, and an algorithm for evaluation. J Infect Dis 1991;164:65664. 128. Stetler HC, Granade TC, Nunez CA, et al. Field evaluation of rapid HIV serologic tests for screening and confirming HIV-1 infection in Honduras. AIDS 1997;11:36975. 129. Horsburgh CR Jr, Jason J, Longini I, et al. Duration of human immunodeficiency virus infection before detection of antibody. Lancet 1989;2:63740. 130. Busch MP, Lee LLJ, Satten GA, et al. Time course of detection viral and serologic markers preceding human immunodeficiency virus type 1 seroconversion: implications for screening of blood and tissue donors. Transfusion 1995;35:917. 131. Jackson JB, MacDonald KL, Cadwell J, et al. Absence of HIV infection in blood donors with indeterminate Western blot tests for antibody to HIV-1. N Eng J Med 1990;322:21722. 132. Dock NL, Kleinman SH, Rayfield MA, Schable CA, Williams AE, Dodd RY. Human immunodeficiency virus infection and indeterminate Western blot patterns: prospective studies in a low prevalence population. Arch Intern Med 1991;151:52530. 133. CDC. HIV counseling and testing in publicly funded sites: annual report, 1997 and 1998. Atlanta, GA: US Department of Health and Human Services, CDC, 2001. 134. Ciesielski CA, Metler RP. Duration of time between exposure and seroconversion in healthcare workers with occupationally acquired infection with human immunodeficiency virus. Am J Med 1997;102:1156. 135. CDC. HIV testing among populations at risk for HIV infectionnine states, November 1995December 1996. MMWR 1998;47:108691. 136. Wykoff RF, Jones JL, Longshore ST, et al. Notification of the sex and needle-sharing partners of individuals with human immunodeficiency virus in rural South Carolina: 30 month experience. Sex Transm Dis 1991;18:21722. 137. Exner TM, Ehrhardt A, Loeb I, Zawadzki R. HIV counseling and testing: women s experiences and the role of testing as a prevention strategy [Abstract We.C.3529]. In: Proceedings of the XI International Conference on AIDS, 1996;11(2):150. 138. Kassler WJ, Meriwether RA, Klimko TB, Peterman TA, Zaidi A. Eliminating access to anonymous HIV antibody testing in North Carolina: effects on HIV testing and partner notification. J Acquir Immune Defic Syndr 1997;14:2819. 139. Simpson WM, Johnstone FD, Goldberg DJ, Gormley SM, Hart GJ. Antenatal HIV testing: assessment of a routine voluntary approach. BMJ 1999;318:16601. 140. Lee JH, Mitchell B, Nolt B, Robbins B, Thomas MC, Branson BM. Targeted opt-in vs. routine opt-out HIV testing in an STD clinic [Abstract 153]. Presented at the 1999 National HIV Prevention Conference, August 29September 1, Atlanta, GA, 1999. 141. Rahimian A, Driscoll M, Taylor D, Cohen M. Barriers to building a comprehensive system of HIV counseling and testing by consent to women of reproductive age in Chicago, Illinois [Abstract Tu.D. 2772]. In: Proceedings of the XI International Conference on AIDS, 1996;1:396. 142. Nutting PA, Main DS, Fischer PM, et al. Problems in laboratory testing in primary care. JAMA 1996;275:6359.
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143. Boone DJ, Steindel SD, Herron R, et al. Transfusion medicine monitoring practices: a study of the College of American Pathologists/CDC Outcomes Working Group. Arch Path Lab Med 1995;119:9991006. 144. Witte DL, VanNess SA, Angstandt DS, Pennell BJ. Errors, mistakes, blunders, outliers, or unacceptable results: how many. Clin Chem 1997;43:13526. 145. Schochetman G, George JR, eds. AIDS testing: a comprehensive guide to technical, medical, social, legal, and management issues. 2 ed. New York, NY: Springer-Verlag, 1994. 146. Institute of Medicine. Eng TR, Butler WT, eds. The hidden epidemic: confronting sexually transmitted diseases. Washington, DC: National Academy Press, 1997. 147. Greenberg JB, MacGowan R, Neumann M, et al. Linking injection drug users to medical services: role of street outreach referrals. Health Soc Work 1998;23:298309. 148. Marx R, Hirozawa AM, Chu PL, Bolan GA, Katz M. Linking clients for HIV antibody counseling and testing to prevention services. J Community Health 1999;24:20114. 149. Hymel MS, Greenberg BL. The Walden House Young Adult HIV Project: meeting the needs of multidiagnosed youth. J Adolesc Health 1998;23S:12231. 150. CDC. Framework for program evaluation in public health. MMWR 1999;48(No. RR-11):140. 151. CDC. Evaluating CDC-funded health department HIV prevention programs. Volume 1: guidance. Atlanta, GA: US Department of Health and Human Services, CDC, 1999.
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Glossary
AIDS: Acquired immunodeficiency syndrome. AIDS can affect the immune and central nervous systems and can result in neurological problems, infections, or cancers. It is caused by human immunodeficiency virus (HIV). Anal sex: A type of sexual intercourse in which a man inserts his penis in his partners anus. Anal sex can be insertive or receptive. Anonymous: In anonymous testing, client identifying information is not linked to testing information, including the request for tests or test results. Antiretroviral therapy: Treatment with drugs designed to prevent HIV from replicating in HIV-infected persons. Highly active antiretroviral therapy (HAART) is an antiretroviral regimen that includes multiple classifications of antiretroviral drugs. Client-centered HIV prevention counseling: An interactive risk-reduction counseling model usually conducted with HIV testing, in which the counselor helps the client identify and acknowledge personal HIV risk behaviors and commit to a single, achievable behavior change step that could reduce the clients HIV risk. Confidentiality: Pertains to the disclosure of personal information in a relationship of trust and with the expectation that it will not be divulged to others in ways that are inconsistent with the original disclosure. Confidentiality must be maintained for persons who are recommended and/or who receive HIV counseling, testing, and referral (CTR) services. Confidential HIV test: An HIV test for which a record of the test and the test results are recorded in the clients chart. Confirmatory test: A highly specific test designed to confirm the results of an earlier (screening) test. For HIV testing, a Western blot or, less commonly, an immunofluorescence assay (IFA) is used as a confirmatory test. EIA: Enzyme immunoassay. Sometimes referred to as ELISA (see next definition). A commonly used screening test to detect antibodies to HIV. ELISA: Enzyme-linked immunosorbent assay. A type of EIA (see previous definition). A commonly used screening test to detect antibodies to HIV. Evaluation: A process for determining how well health systems, either public or private, deliver or improve services and for demonstrating the results of resource investments. False negative: A negative test result for a person who is actually infected. False positive: A positive test result for a person who is actually not infected.
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Freestanding HIV test site: A site that provides only HIV services. Sometimes referred to as alternate test site or anonymous test site. HIV: Human immunodeficiency virus, which causes AIDS. Several types of HIV exist, with HIV-1 being the most common in the United States. HIV test: More correctly referred to as an HIV antibody test, the HIV test is a laboratory procedure that detects antibodies to HIV, rather than the virus itself. HIV prevention counseling: An interactive process between client and counselor aimed at reducing risky sex and needle-sharing behaviors related to HIV acquisition (for HIV-uninfected clients) or transmission (for HIV-infected clients). See also clientcentered HIV prevention counseling. Home sample collection test: A test that a consumer purchases and uses to collect blood (or other bodily fluid) and then send it out for testing. Counseling and test results are typically provided by telephone using user-generated codes to ensure confidentiality and anonymity. Incidence: In epidemiology, the number of new cases of infection or disease that occur in a defined population within a specified time. Indeterminate test result: A possible result of a Western blot, which might represent a recent HIV infection or a false-positive. Information: In the context of HIV counseling, information encompasses the topics HIV transmission and prevention and the meaning of HIV test results. Informed consent: The legally effective permission of a client or legally authorized representative (e.g., parent or legal guardian of a minor child) to undergo a medical test or procedure. Negative predictive value: A negative predictive value estimates the probability that a person with a negative diagnostic test result will actually not be infected. Nonoccupational HIV exposure: A reported sexual, injection-druguse, or other nonoccupational HIV exposure that might put a patient at high risk for acquiring HIV infection. Nucleic acid amplification testing: A type of testing that identifies viral genes (e.g., specific sequences of nucleic acids) using gene amplification technologies such as polymerase chain reaction (PCR). Occupational HIV exposure: An occupational exposure to HIV that occurs during the performance of job duties. Defined as a percutaneous injury (e.g., a needlestick or cut with a sharp object), contact of mucous membranes, or contact of skin (especially when the exposed skin is chapped, abraded, or afflicted with dermatitis or the contact is prolonged or involving an extensive area) with blood, tissues, or other body fluids to which universal precautions apply.
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Oral fluid test: A test using oral mucosal transudate, a serous fluid. To differentiate this fluid from saliva, an absorbent material is left in the mouth for several minutes. In an HIV-infected person, oral mucosal transudate is likely to contain HIV antibodies. Oral sex: A type of sexual intercourse in which the partners genitals are stimulated by mouth and tongue. Partner counseling and referral services (PCRS): A prevention activity that aims to a) provide services to HIV-infected persons and their sex and needle-sharing partners so they can reduce their risk for infection or, if already infected, can prevent transmission to others and b) help partners gain earlier access to individualized counseling, HIV testing, medical evaluation, treatment, and other prevention and support services. Perinatal HIV transmission: Transmission of HIV from the mother to the fetus or infant during pregnancy, delivery, or breast-feeding. Positive predictive value: A positive predictive value estimates the probability that a person with a positive diagnostic test result will actually be infected. Positive test: For HIV, a specimen sample that is reactive on an initial ELISA test, repeatedly reactive on a second ELISA run on the same specimen, and confirmed positive on Western blot or other supplemental test indicates that the client is infected. Prevalence: The number or percentage of persons in a given population with a disease or condition at a given point in time. Prevention case management (PCM): A client-centered HIV prevention activity that promotes adoption of HIV risk-reduction behaviors by clients with multiple, complex problems and risk-reduction needs. PCM is a hybrid of HIV prevention counseling and traditional case management that provides intensive, on-going, individualized prevention counseling, support, and referral to other needed services. Prevention counseling: An interactive process between client and counselor aimed at reducing risky sex and needle-sharing behaviors related to HIV acquisition (for HIVuninfected clients) or transmission (for HIV-infected clients). See also client-centered HIV prevention counseling and HIV prevention counseling. Quality assurance: An ongoing process for ensuring that the CTR program effectively delivers a consistently high level of service to the clients. Rapid HIV test: A test to detect antibodies to HIV that can be collected and processed within a short interval of time (e.g., approximately 1060 minutes). Referral: The process through which a client is connected with services to address prevention needs (medical, prevention, and psychosocial support).
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Risk assessment: Risk assessment is a fundamental part of a client-centered HIV prevention counseling session in which the client is encouraged to identify, acknowledge, and discuss in detail his or her personal risk for acquiring or transmitting HIV. Risk screening: A brief evaluation of HIV risk factors, both behavioral and clinical, used for decisions about who should be recommended HIV counseling and testing. Risk screening is different from risk assessment. Screening test: An initial test, usually designed to be sensitive, to identify all persons with a given condition or infection (e.g., enzyme immunoassay [EIA] or enzyme-linked immunosorbent assay [ELISA]). Sensitivity: The probability that a test will be positive when infection or condition is present. Seroconversion: Initial development of detectable antibodies specific to a particular antigen; the change of a serologic test result from negative to positive as a result of antibodies induced by the introduction of antigens or microorganisms into the host. Specificity: The probability that a test will be negative when the infection or condition is not present. Tuberculosis (TB) disease: Active disease caused by Mycobacterium tuberculosis, as evidenced by a confirmatory culture, or, in the absence of culture, suggestive clinical symptoms, including productive cough lasting >3 weeks, chest pain, hemoptysis, fever, night sweats, weight loss, and easy fatigability. Active TB is a communicable disease that is treatable, curable, and preventable, and persons with active TB disease should be under the care of a health-care provider. Active TB disease could indicate immune deficiency. For HIV-infected persons, active TB disease is considered an opportunistic infection and a qualifying condition for AIDS. Tuberculosis (TB) infection: Infection with the bacteria M. tuberculosis, as evidenced by a positive tuberculin skin test (TST) that screens for infection with this organism. Sometimes, TST is called a purified protein derivative (PPD) or Mantoux test. A positive skin test might or might not indicate active TB disease (see tuberculosis disease). Thus, any person with a positive TST should be screened for active TB and, once active TB is excluded, evaluated for treatment to prevent the development of TB disease. TB infection alone is not considered an opportunistic infection indicating possible immune deficiency. Vaginal sex: A type of sexual intercourse in which the mans penis enters the womans vagina. Voluntary HIV testing: HIV testing that is offered free of coercion. With voluntary HIV testing, participants have the opportunity to accept or refuse HIV testing. Western blot: A laboratory test that detects specific antibodies to components of a virus. Chiefly used to confirm HIV antibodies in specimens found repeatedly reactive using ELISA.
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INSTRUCTIONS
By Internet 1. Read this MMWR (Vol. 50, RR-19, Revised Guidelines for HIV Counseling, Testing, and Referral ), which contains the correct answers to the questions beginning on the next page. 2. Go to the MMWR Continuing Education Internet site at <http://www.cdc.gov/mmwr/cme/conted.html>. 3. Select which exam you want to take and select whether you want to register for CME, CEU, or CNE credit. 4. Fill out and submit the registration form. 5. Select exam questions. To receive continuing education credit, you must answer all of the questions. Questions with more than one correct answer will instruct you to Indicate all that apply. 6. Submit your answers no later than November 9, 2004. 7. Immediately print your Certificate of Completion for your records. By Mail or Fax 1. Read this MMWR (Vol. 50, RR-19, Revised Guidelines for HIV Counseling, Testing, and Referral ), which contains the correct answers to the questions beginning on the next page. 2. Complete all registration information on the response form, including your name, mailing address, phone number, and e-mail address, if available. 3. Indicate whether you are registering for CME, CEU, or CNE credit. 4. Select your answers to the questions, and mark the corresponding letters on the response form. To receive continuing education credit, you must answer all of the questions. Questions with more than one correct answer will instruct you to Indicate all that apply. 5. Sign and date the response form or a photocopy of the form and send no later than November 9, 2004, to Fax: 404-639-4198 Mail: MMWR CE Credit Office of Scientific and Health Communications Epidemiology Program Office, MS C-08 Centers for Disease Control and Prevention 1600 Clifton Rd, N.E. Atlanta, GA 30333 6. Your Certificate of Completion will be mailed to you within 30 days.
ACCREDITATION
Continuing Medical Education (CME). CDC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. CDC designates this educational activity for a maximum of 2.75 hours in category 1 credit toward the AMA Physicians Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the educational activity. Continuing Education Unit (CEU). CDC has been approved as an authorized provider of continuing education and training programs by the International Association for Continuing Education and Training and awards 0.25 hour Continuing Education Units (CEUs). Continuing Nursing Education (CNE). This activity for 3.1 contact hours is provided by CDC, which is accredited as a provider of continuing education in nursing by the American Nurses Credentialing Centers Commission on Accreditation.
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To receive continuing education credit, please answer all of the following questions.
1.
Which of the following are goals of HIV CTR? A. B. C. D. Ensure that HIV-infected persons and persons at increased risk for HIV have access to HIV testing to promote early knowledge of their HIV status. Ensure that HIV-infected persons and persons at increased risk for HIV receive highquality HIV prevention counseling to reduce their risk for transmitting or acquiring HIV. Ensure that HIV-infected persons and persons at increased risk for HIV have access to appropriate medical, preventive, and psychosocial support services. All of the above.
2.
HIV counseling conducted along with HIV testing serves the following purposes: A. B. C. D. Provides information regarding how HIV infection is transmitted and prevented, the importance of obtaining test results, and the meaning of HIV test results. Helps clients identify HIV risks and commit to steps to reduce their risks for acquiring or transmitting HIV infection. Both A and B. None of the above.
3.
The primary focus of HIV prevention counseling is to . . . A. B. C. D. ensure that the counseling is sensitive to the clients culture, language, sex, sexual orientation, age, and developmental level. remain respectful of the client and maintain a nonjudgmental approach. ensure that the client fully interacts with the counselor in the counseling session. reduce the clients personal risk for HIV acquisition or transmission.
4.
Essential elements of HIV prevention counseling include all of the following except: A. B. C. D. Keep the session focused on HIV risk reduction. Include an in-depth, personalized risk assessment. Acknowledge and provide support for HIV prevention steps already taken. Ensure that all of the clients misconceptions regarding HIV infection, including those not related to the clients personal risk, are clarified.
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Procedures that help ensure high-quality HIV prevention counseling include all of the following except: A. B. C. D. Training and continued education for counseling staff members. Routine, periodic observation and feedback of counseling sessions. Routine collection of key data elements for evaluation during the counseling session. Support from supervisors and policy makers.
6.
Anonymous testing for HIV infection is beneficial in the following ways: A. B. C. D. Increasing the number of persons who know their HIV status. Promoting follow-up. Promoting earlier treatment. All of the above.
7.
Which of the following factors help determine who should be recommended an HIV test? A. B. C. D. Behavioral HIV risk of client population. HIV prevalence of population at facility. Availability of effective treatment for HIV prevention (e.g., perinatal transmission). All of the above.
8.
Which of the following is the best definition of referral? A. B. C. D. An ongoing relationship with a client that includes assessing a clients medical and psychosocial support needs and providing care for those needs. A process in which a clients need for medical, preventive, and supportive services is assessed, and the client is assisted in accessing appropriate services. An interactive process aimed at reducing risky behaviors related to HIV acquisition or transmission. An evaluation of risk factors for HIV infection used to make decisions regarding who should be offered HIV testing.
9.
Which statement is true regarding counseling, testing, and referral services in nontraditional settings (e.g., community-based and outreach settings)? A. B. C. D. These services could benefit from the use of new HIV test technologies. These services require quality assurance protocols and procedures tailored specifically for these settings. These services help reach persons at increased risk for HIV infection. All of the above.
CE4-19a1 10. Indicate your work setting. A. B. C. D. E. F. State/local health department. Other public health setting. Hospital clinic/private practice. Managed care organization. Academic institution. Other.
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11. Which best describes your professional activities? A. B. C. D. E. F. Laboratory/pharmacy. Counseling. Administration. Patient care private medical setting. Client care publicly funded site. Public health.
12. I plan to use these guidelines as the basis for . . . (Indicate all that apply.) A. B. C. D. E. health education materials. insurance reimbursement policies. local practice guidelines. public policy. other.
13. Each month, approximately how many HIV-infected patients/clients do you see? A. B. C. D. E. F. None. 15. 620. 2150. 51100. >100.
14. How much time did you spend reading this report and completing the exam? A. B. C. D. E. Fewer than 1.5 hours. More than 1.5 hours but fewer than 2 hours. 22.5 hours. More than 2.5 hours but fewer than 3 hours. 3 hours or more.
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15. After reading this report, I am confident I can identify the goals of HIV counseling, testing, and referral. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
16. After reading this report, I am confident I can describe the primary focus and essential elements of HIV prevention counseling. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
17. After reading this report, I am confident I can describe the factors that determine who should be offered an HIV test. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
18. After reading this report, I am confident I can identify the factors that should be considered when determining the timing of follow-up HIV testing. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
19. The objectives are relevant to the goal of this report. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
CE6-19a1 20. The tables and figures are useful. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
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21. Overall, the presentation of the report enhanced my ability to understand the material. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
22. These recommendations will affect my practice. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
23. How did you learn about this continuing education activity? A. B. C. D. E. F. Internet. Advertisement (e.g., fact sheet, MMWR cover, newsletter, or journal). Coworker/supervisor. Conference presentation.
MMWR subscription.
Other.
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MMWR Response Form for Continuing Education Credit November 9, 2001/Vol. 50/No. RR-19a1
Revised Guidelines for HIV Counseling, Testing, and Referral
To receive continuing education credit, you must 1. provide your contact information; 2. indicate your choice of CME, CEU, or CNE credit; 3. answer all of the test questions; 4. sign and date this form or a photocopy; 5. submit your answer form by November 9, 2004. Failure to complete these items can result in a delay or rejection of your application for continuing education credit.
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Fill in the appropriate blocks to indicate your answers. Remember, you must answer all of the questions to receive continuing education credit!
1. 2. 3. 4. 5. 6. 7. 8. 9. []A []A []A []A []A []A []A []A []A []B []B []B []B []B []B []B []B []B []B []B []B []C []C []C []C []C []C []C []C []C []C []C []C []D []D []D []D []D []D []D []D []D []D []D []D []E []E []E []F []F 13. [ ] A 14. [ ] A 15. [ ] A 16. [ ] A 17. [ ] A 18. [ ] A 19. [ ] A 20. [ ] A 21. [ ] A 22. [ ] A 23. [ ] A []B []B []B []B []B []B []B []B []B []B []B []C []C []C []C []C []C []C []C []C []C []C []D []D []D []D []D []D []D []D []D []D []D []E []E []E []E []E []E []E []E []E []E []E []F []F
Signature
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Perinatal Counseling and Guidelines Consultation April 2627, 1999 Atlanta, Georgia
Deborah Allen, Sc.D. Division of Children With Special Health Needs Bureau of Family and Community Health Massachusetts Department of Public Health Boston, Massachusetts Arthur Ammann, M.D. Global Strategies for HIV Prevention San Rafael, California Helen Bailey AIDS Arms Dallas, Texas Cornelius Baker National Association of People with AIDS Washington, D.C. Rosie Berger United Health Care New York, New York Guthrie Birkhead, M.D., M.P.H. Council of State and Territorial Epidemiologists Albany, New York Mary Boland, M.S.N., F.A.A.N. University of Medicine & Dentistry of New Jersey Newark, New Jersey Cary Colman Health Education Department Kaiser Permanente Panorama City, California Ezra Davidson, Jr., M.D. Charles R. Drew University of Medicine & Science Los Angeles, California Rebecca Denison WORLD Oakland, California Maria Isabel Fernandez, Ph.D. Department of Psychiatry & Behavioral Sciences University of Miami School of Medicine Miami, Florida Toni Frederick, Ph.D. Pediatric Spectrum of Disease Study Los Angeles County Department of Health Services Los Angeles, California Donna Futterman, M.D. Adolescent AIDS Program, Montefiore Medical Center and Albert Einstein College of Medicine Bronx, New York Meliset Garcia Disease Division Childrens Hospital Pediatric Infectious Springfield, Massachusetts Randy Graydon Division of Advocacy & Special Issues Health Care Financing Administration Baltimore, Maryland David Harvey AIDS Policy Center for Children, Youth, & Families Washington, DC Rashidah Hassan Family Planning Council Philadelphia, Pennsylvania Catherine Hess Association of Maternal & Child Health Programs Washington, D.C. Debra Hickman Sisters Together & Reaching Baltimore, Maryland Roslyn Howard-Moss Johns Hopkins OBGYN Department Baltimore, Maryland Jeanette Ickovics, Ph.D. Department of Epidemiology Yale University School of Medicine New Haven, Connecticut Ann Koontz, Dr.PH. Division of Perinatal Systems/Womens Health Maternal & Child Health Bureau Rockville, Maryland
Vol. 50 / No. RR-19 Marlene LaLota, M.P.H. Bureau of HIV/AIDS, Department of Health Tallahassee, Florida
MMWR Gwendolyn B. Scott, M.D. Division of Pediatric Infectious Diseases and Immunology, University of Miami School of Medicine Miami, Florida
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Zita Lazzarini, J.D., M.P.H. Program in Medical Humanities, Health Law and Ethics University of Connecticut Health Center Farmington, Connecticut Robert Levine, M.D. Professor of Medicine Yale University School of Medicine Woodbridge, Connecticut Michael Lindsay, M.D. Department of OB-GYN Emory University Atlanta, Georgia Katherine Luzuriaga, M.D. University of Massachusetts Medical School Worcester, Massachusetts Miguelina Maldonado, M.S.W. National Minority AIDS Council Washington, D.C. James McNamara, M.D. National Institutes of Health Rockville, Maryland Lynne Mofenson, M.D. National Institutes of Health/NICHD Rockville, Maryland Angus Nicoll, F.R.C.P.H., F.F.P.H.M., F.R.C.P. HIV and STD Division, PHLS Communicable Disease Surveillance Centre London, England Deborah Parham, Ph.D. Health Resources and Services Administration Rockville, Maryland Sindy Paul, M.D. Division of AIDS Prevention and Control New Jersey Department of Health Trenton, New Jersey Jim Pearson, Dr.PH. Virginia Department of Health Richmond, Virginia Laura Riley, M.D. Massachusetts General Hospital Boston, Massachusetts
Maureen Shannon Association of Womens Health, Obstetric, and Neonatal Nurses San Francisco, California Melissa Simmons Childrens Diagnostic and Treatment Center Sunrise, Florida Christa-Marie Singleton, M.D., M.P.H. Maternal and Child Health Policy Association of State and Territorial Health Officers Washington, D.C. Sheperd Smith The Children AIDS Fund Herndon, Virginia Pauline Thomas, M.D. Office of AIDS Surveillance New York City Department of Health New York, New York Kate Thomsen, M.D. Planned Parenthood Federation of America New York, New York Deborah Von Zinkernagel Office of HIV/AIDS Policy Washington, D.C. Diane Wara, M.D. University of California, San Francisco San Francisco, California Theresa Watkins-Bryant, M.D. Division of Programs for Special Populations Bureau of Primary Health Care Bethesda, Maryland Catherine Wilfert, M.D. Duke University Medical Center Chapel Hill, North Carolina Carmen Zorilla, M.D. University of Puerto Rico San Juan, Puerto Rico
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The following CDC staff members prepared this report: Martha F. Rogers, M.D. Mary Glenn Fowler, M.D., M.P.H. Mary Lou Lindegren, M.D. Division of HIV/AIDS Prevention Surveillance and Epidemiology National Center for HIV, STD, and TB Prevention
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INTRODUCTION
In 1994, after the announcement of the results of Pediatric AIDS Clinical Trials Group (PACTG) protocol 076 (1 ), the Public Health Service (PHS) published guidelines for zidovudine (ZDV) use to reduce perinatal human immunodeficiency virus (HIV) transmission (2 ). In 1995, PHS issued guidelines recommending universal counseling and voluntary HIV testing of all pregnant women and treatment for those infected (3 ). Publication of these recommendations was followed by rapid implementation by health-care providers, widespread acceptance of chemoprophylaxis by HIV-infected women, and a steep
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and sustained decline in perinatal HIV transmission (4,5 ). Observational studies have confirmed the effectiveness of ZDV in reducing the risk for perinatal transmission (68 ). This reduction in transmission risk resulted in an 83% decline in perinatal acquired immunodeficiency syndrome (AIDS) cases diagnosed in 1999, compared with the peak incidence of 907 cases in 1992 (7 ). Despite this progress, children are still being infected perinatally. CDC estimates that 280370 infants are born with HIV infection each year in the United States (CDC, unpublished data, 2000). These continued infections underscore the need for improved strategies to ensure that all pregnant women are offered HIV testing and, if positive, treatment to reduce their transmission risk and to safeguard their health and the health of their infants. Several lessons have been learned from evaluation of the 1995 PHS guidelines. Many women, especially those who used illicit drugs, were not tested for HIV during pregnancy because of lack of prenatal care (8 ). In addition, many women refused testing because their health-care providers did not strongly recommend it. Some women declined testing because of perceived low risk, and some providers failed to offer testing because of perceived low risk, perceived difficulties and complexity of required counseling, and misunderstanding of counseling requirements. The logistics of testing, if too complex, also were considered a potential barrier to testing. In December 1998, the Institute of Medicine (IOM) completed a study commissioned by Congress to assess the impact of current approaches for reducing perinatal HIV transmission, identify barriers to further reductions, and determine ways to overcome these barriers (9 ). IOM concluded that continued perinatal transmission was mainly caused by a lack of awareness of HIV status among some pregnant women. This problem was attributed to some health-care providers not offering HIV testing to all pregnant women because the providers believed they could predict which women were most at risk and that standard HIV testing protocols, particularly the requirement for extensive pretest counseling, were too burdensome to conduct for all women. IOM concluded that HIV testing should be simplified and made routine. They recommended that the United States adopt a national policy of universal HIV testing, with patient notification, as a routine component of prenatal care. That is, testing should be offered to all pregnant women as part of the standard battery of prenatal tests, regardless of risk factors and the prevalence rates in the community. IOM also recommended that women be informed when an HIV test is conducted and of their right to refuse testing. Since 19941995, major scientific advances in the prevention of perinatal transmission and the care of HIV-infected persons have occurred. These advances increased the benefit of knowing ones HIV status, especially during pregnancy. More effective treatment has prolonged survival of HIV-infected persons and improved their quality of life (10 ). Clinical trials proved the effectiveness of prophylactic therapy for preventing perinatal transmission in women who are not treated until the time of delivery (11 ). Studies have indicated that women with nondetectable viral load rarely transmit HIV infection (1214 ). Finally, new testing technologies (e.g., rapid testing, urine sampling) offer new options for HIV screening. To address the lessons learned, IOM findings, and scientific advances, as well as the causes of continued HIV infection in children, PHS convened specialists in the field in April 1999 and sought widespread public comment in revising the 1995 guidelines for HIV counseling and testing for pregnant women. Consultation groups included researchers,
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professional health-care provider organizations (e.g., American Academy of Pediatrics, American College of Obstetricians and Gynecologists), clinicians, women living with HIV, and representatives from community organizations and PHS agencies overseeing care of HIV-infected pregnant women. The resulting guidelines are presented in this document. They differ from the 1995 guidelines in that they emphasize HIV testing as a routine part of prenatal care and strengthen the recommendation that all pregnant women be tested for HIV, recommend simplifying the testing process so that pretest counseling is not a barrier to testing, increase the flexibility of the consent process to allow for various types of informed consent, recommend that providers explore and address reasons for refusal of testing, and emphasize HIV testing and treatment at the time of labor and delivery for women who have not received prenatal testing and chemoprophylaxis. These guidelines maintain a voluntary approach to HIV testing. This voluntary approach preserves a womans right to make decisions regarding testing and supports a womans right to refuse testing if she does not think it is in her best interest. This document replaces the 1995 PHS guidelines (3 ). These recommendations are primarily intended for providers of health care for women, with a focus on HIV screening of pregnant women to reduce mother-to-child transmission of HIV. This report does not address other concerns related to continued perinatal transmission (e.g., lack of prenatal care). CDC programs targeted to states with the highest incidence of perinatal HIV infection address these ongoing public health problems (information on these programs is available on the Internet at <http://www.cdc.gov/hiv/projects/perinatal/default.htm>). Other PHS guidelines address the importance of prevention interventions, including testing in the general population (see Revised Guidelines for HIV Counseling, Testing, and Referral ). This report applies only to the United States; different recommendations, especially on breast-feeding, will apply in other countries.
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women are disproportionately affected by the epidemic and account for 80% of AIDS cases reported in U.S. women in 1999. Over time, the proportion of cases in women attributable to injection-drug use has declined, whereas the proportion of cases from heterosexual contact has increased, particularly among young women. During 19851995, approximately 6,0007,000 HIV-infected women gave birth in the United States each year (7 ). During the early 1990s, before perinatal chemoprophylaxis was available, an estimated 1,0002,000 infants were born with HIV infection annually. By June 2000, a total of 8,027 perinatally acquired AIDS cases were recorded nationwide, most (85%) in African-American and Hispanic children (7,15 ). Before the results of the PACTG 076 trial using prenatal, intrapartum, and postpartum ZDV for perinatal prophylaxis, the risk for mother-to-child transmission ranged from 16% to 25% in studies from North America and Europe (1719 ), up to 24% in Thailand (20 ), and 2540% in Africa (21,22 ). Worldwide, approximately 600,000 infants each year become infected through mother-to-child transmission of the HIV virus. In the United States, widespread implementation of the PHS guidelines for universal counseling and testing and perinatal use of ZDV has sharply reduced transmission risk and the number of perinatally acquired HIV infections (7 ). By 1995, several cohort studies had documented transmission rates of <11% (19,23 ). During 19962000, U.S. studies indicated that transmission rates had declined to 5%6% (12,24 ) and <1% in women with nondetectable plasma viral loads (12,14,25 ). During 20002001, perinatal transmission rates of <2% have been achieved with combination antenatal antiretroviral drugs (26 ) or with ZDV combined with cesarean section (2729 ). Analysis of U.S. perinatal AIDS surveillance data (15 ) reported through June 2000 indicated a sharp decline in the number of perinatal AIDS cases; this decline was temporally associated with increasing ZDV use among pregnant women aware of their HIV status (7 ). To more accurately monitor trends in perinatal HIV transmission and the implementation and impact of perinatal prevention programs (including HIV counseling and testing recommendations), CDC, the Council of State and Territorial Epidemiologists (CSTE), and the American Academy of Pediatrics (AAP) recommended national reporting of perinatal HIV exposure and HIV infection to help identify and target populations where prevention opportunities are missed (30,31 ). Despite the declines, cases of perinatal HIV transmission continue to occur, largely because of missed opportunities for prevention, particularly among women who lack prenatal care or who are not being offered voluntary HIV counseling and testing during pregnancy. The estimated 280370 infants born with HIV infection each year represent populations in which prevention efforts are impeded by lack of timely HIV testing and treatment of pregnant women (7 ). Of 329 children with perinatally acquired AIDS born during 19951996, a total of 112 (34%) were born to mothers not tested for HIV before the childs birth and 67 (20%) to mothers for whom the time of testing was not known.
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associated with intrauterine transmission, 60%70% with intrapartum transmission or very early breast-feeding, and 10%15% with later postpartum transmission through breast-feeding (33 ). In a randomized trial of formula feeding versus breast-feeding, approximately 44% of HIV infection was attributed to breast-feeding (34 ). In breastfeeding populations, a shift toward an increasing proportion of transmission related to breast-feeding is likely to occur as a consequence of successful preventive interventions directed at late prenatal and intrapartum transmission. Intrapartum transmission can occur during labor through maternal-fetal exchange of blood or during delivery by contact of the infants skin or mucous membranes with infected blood or other maternal secretions (32 ). Several studies have indicated that most infections transmitted through breast-feeding probably occurred during the first few weeks to months of life (3436 ). Risk factors during breast-feeding include viral load in breast milk (37,38 ), subclinical or clinical mastitis (37,39,40 ), breast abscesses (39,40 ), and maternal seroconversion during the lactation period (39,41 ). Several risk factors are associated with perinatal HIV transmission. Clinical factors that increase the likelihood of transmission include immunologically or clinically advanced HIV disease in the mother, high plasma viral load (12,25,42 ), maternal injection-drug use during pregnancy, preterm delivery, nonreceipt of the PACTG 076 regimen, and breastfeeding (32 ). No link has been established between perinatal HIV transmission and maternal age, race/ethnicity, or history of having a previously infected child. Obstetric factors also influence HIV transmission risk. The risk for perinatal transmission increases per hour duration of membrane rupture after controlling for other risk factors (43 ). Delivery >4 hours after the rupture of the fetal membranes can double the risk for HIV transmission (19,44 ). Maternal infection with another sexually transmitted disease (STD) during pregnancy and certain obstetrical procedures can also increase risk (45 ). Chorioamnionitis (i.e., uterine infection) has been associated with an increased risk for HIV transmission (23,46 ). Most of these risk factors were identified before the recommended use of ZDV to prevent perinatal HIV transmission. Their effects are unknown now that most pregnant women infected with HIV are receiving ZDV chemoprophylaxis to prevent mother-tochild transmission, as well as combination therapy for their own health. Because of the sharp reductions in perinatal HIV transmission associated with effective antiretroviral interventions, factors that interfere with women or their infants receiving ZDV treatment (e.g., barriers to prenatal care, lack of HIV testing for some pregnant women) are increasingly important (9 ).
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time of delivery. In the PACTG 076 protocol, chemoprophylaxis consisted of three components: ZDV administered orally to the mother during the second and third trimesters of pregnancy, intravenous administration of ZDV to the mother during labor and delivery, and administration of oral ZDV to the infant during the first 6 weeks of life (1 ). Data from several sources demonstrated rapid implementation of the recommendations for ZDV prophylaxis by health-care providers and use of ZDV by HIV-infected pregnant women. One study analyzed approximately 6,800 perinatally exposed and infected children born during 19931998 in 32 states that reported HIV infection (51 ). Among those whose mothers were tested for HIV before or at birth of the infant, the percentage of infants receiving any component of the recommended ZDV regimen increased from 37% in 1994 to approximately 85% during 19961998. In a supplemental study of women diagnosed before delivery in four states, the proportion offered prenatal ZDV increased from 27% in 1993 to 85% in 1996, the proportion offered intrapartum ZDV increased from 5% to 75%, and the proportion offered neonatal ZDV increased from 5% to 76% (5 ). Fewer than 5% of women refused ZDV.
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antiretroviral therapy. However, cesarean delivery is associated with greater morbidity than vaginal delivery among both HIV-infected and noninfected women (58 ). In 1999 and 2000, the American College of Obstetricians and Gynecologists (ACOG) recommended offering scheduled cesarean delivery at 38 weeks gestation to reduce the risk for vertical transmission of HIV infection (57,59 ). Other intrapartum interventions alone (e.g., vaginal disinfection during labor and cleansing of the newborn) have not proven effective (60 ).
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Follow-up of infants, both infected and uninfected, who are exposed to antiretroviral drugs is critical to identifying potential short- and long-term toxicities. Data on the risks of antiretroviral drugs during pregnancy are summarized and updated regularly (57 ).
Legal Considerations
IOMs recommendations prompted reconsideration of the focus, implementation, and impact of PHSs guidelines for HIV screening of pregnant women. These guidelines recommended counseling all pregnant women regarding the risk for HIV infection, benefits of HIV testing, and voluntary testing. This approach was endorsed by most professional organizations representing prenatal, obstetrical, and perinatal-care providers. States quickly implemented the guidelines, but with substantial variability in strategy (68 ). Most states responded with policies on HIV counseling and testing of pregnant women; approximately 50% also enacted laws or regulations. Most policies and statutes are directed at pregnant women rather than newborns and focus on education, counseling, and consensual testing. New York and Connecticut are the only states that mandate newborn testing. No evidence exists to indicate that any legal approach is more successful than others in preventing perinatal transmission. No states require mandatory testing
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of pregnant women. In considering adopting the IOM guidelines, some states have implemented or are considering requiring some form of pretest counseling, routine testing with right of refusal, or universal or selective newborn screening. IOMs recommendation is for universal HIV testing with patient notification. As states consider implementing the IOM recommendations, other important considerations include availability of care and treatment for HIV-infected mothers and their infants, provider training needs, and confidentiality laws to protect positive test results reported to public health surveillance. States should consult with public health officials, health-care providers, and representatives of affected communities during this process. For the individual woman, the substantial benefits of HIV testing must be weighed against the possible risks. Potential negative consequences of a diagnosis of HIV infection can include loss of confidentiality, job- or health-carerelated discrimination and stigmatization, loss of relationships, domestic violence, and adverse psychological reactions (69 ). Providing HIV-infected women with or referring them to psychological, social, and legal services could help minimize these risks and allow more women to benefit from the health advantages of early HIV diagnosis without adverse consequences. The Americans with Disabilities Act (ADA) of 1990 and other federal, state, and local antidiscrimination provisions aim to protect persons with HIV/AIDS against discrimination in the workplace, housing, public services, and public accommodations (70 ). A 1998 U.S. Supreme Court decision provided further antidiscrimination protection by ensuring that persons with asymptomatic HIV disease are included under ADA and have access to nondiscriminatory and effective health care (70 ).
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73
for maternally acquired HIV-1 antibody indicated a relatively low rate of indeterminate Western blot results (<1 in 4,000 specimens tested by EIA) (74 ). Overall, 2,845 Western blots were performed. False-positive Western blot results (especially those with a majority of bands) are rare. For example, in a study that used a sensitive culture technique to test approximately 290,000 blood donors , no false-positive Western blot results were detected (75 ). In a study of the frequency of false-positive diagnoses among military applicants from a low-prevalence population (i.e., <1.5 infections/1,000 population), one false-positive result was detected among 135,187 persons tested (76 ). An HIV test should be considered positive only after screening and confirmatory tests are reactive. A confirmed positive test result indicates that a person has been infected with HIV. False-positive results when both screening and confirmatory tests are reactive are rare. However, the possibility of a mislabeled sample or laboratory error must be considered, especially for a client with no identifiable risk for HIV infection. HIV vaccineinduced antibodies may be detected by current tests and may cause a false-positive result. Persons whose test results are HIV-positive and who are identified as vaccine trial participants should be encouraged to contact or return to their trial site or an associated trial site for HIV counseling, testing, and referral (CTR) services. Incorrect HIV test results occur primarily because of specimen-handling errors, laboratory errors, or failure to follow the recommended testing algorithm (76 ). However, patients might report incorrect test results because they misunderstood previous test results or misperceived that they were infected (77 ). Although these occurrences are rare, increased testing of pregnant women will result in additional indeterminate, falsepositive, and incorrect results. Because of the significance of an HIV-positive test result, its impact on a womans reproductive decisions, and the resulting need to consider HIV therapeutic drugs for both a pregnant woman and her infant, previous guidelines have emphasized that HIV test results must be obtained and interpreted correctly. In some circumstances, correct interpretation might require consideration of not only additional testing but also the womans clinical condition and history of possible exposure to HIV.
74
MMWR
November 9, 2001
the population tested. Because HIV prevalence is low in most perinatal testing settings, the negative predictive value of a single rapid test (i.e., the probability that a negative test accurately indicates that the person tested is uninfected) is high. A negative rapid test does not require further testing. In contrast, the positive predictive value of a single test (i.e., the probability that a positive test represents true infection) will be low among populations with low prevalence (71 ). Therefore, a reactive rapid test must be confirmed by a supplemental test (e.g., Western blot). However, necessary peripartum interventions to reduce the risk for perinatal transmission might need to be based on the preliminary results of rapid testing at labor and delivery. Decisions regarding use of antiretroviral drugs to prevent perinatal transmission among women who are repeatedly reactive on a single rapid HIV test require clinical judgment regarding initiation of prophylactic treatment before results of a confirmatory test are available. Only one FDA-approved rapid HIV test (Abbott Murex Single Use Diagnostic System [SUDS] HIV-1 test, Abbott Laboratories, Inc., Abbott Park, Illinois) is commercially available in the United States, although other rapid tests are being considered for approval. This test can provide definitive negative and preliminary positive test results at the time of testing and identify women who might need antiretroviral treatment and whose infants might benefit from chemoprophylaxis. A careful risk assessment could help make treatment decisions. The predictive value of a reactive rapid test is higher among persons with risk for HIV infection, especially in areas with high HIV prevalence (79 ). Use of a second screening test (either rapid test or EIA) can also improve the positive predictive value of a single reactive rapid HIV test. In studies conducted outside the United States, specific combinations of >2 different screening assays provided results as reliable as those from the conventional EIA/Western blot combination (80 ). Expedited EIA testing that produces results within a few hours can also aid decisions regarding antiretroviral therapy. Although results from standard testing are not likely to be available during labor and delivery, they could be available within 12 hours of an infants birth. Because neonatal prophylaxis might be effective in reducing risk for transmission (24 ), expedited application of the standard testing protocol is another way to reduce mother-to-child infection. Research and programmatic studies are underway to assess the feasibility of offering voluntary HIV counseling and rapid testing at labor and delivery to women of unknown serostatus in the United States. Implementation of rapid testing and expedited EIA approaches should address several ethical and logistical considerations, including acceptability of rapid HIV testing in the labor room, difficulty in obtaining informed consent for testing and treatment during labor or soon after birth, acceptance of intrapartum and postpartum ZDV prophylaxis for the mother or infant, optimal timing of posttest counseling, logistical concerns for providers, implications of preliminary reactive test results, and comprehension of discussions regarding antiretroviral treatment by women who are in labor (81,82 ).
MMWR
75
A CDC-funded, multicenter initiative called Mother-Infant Rapid Intervention at Delivery (MIRIAD) is underway to address these considerations among women with inadequate prenatal care in communities with high HIV seroprevalence among women of childbearing age (81 ). If successful, this initiative will offer crucial peripartum interventions to reduce the risk for HIV transmission among HIV-infected women first identified at labor and delivery.
RECOMMENDATIONS
The following revised recommendations for HIV screening of pregnant women are based on scientific and clinical advances in preventing perinatally acquired HIV and caring for HIV-infected women, recommendations from IOM, consultations with specialists in the field, and public opinion. They reflect the need for universal HIV testing of all pregnant women and simplification of the pretest process so that operational procedures do not impede women from benefitting from proven measures to prevent perinatal transmission and from other advances in the care and treatment of HIV disease. Although universal testing is recommended, testing should remain a voluntary decision by the pregnant woman.
76
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November 9, 2001
who initially refuse testing might accept at a later date, particularly if their concerns are discussed. Some women who refuse confidential testing might be willing to obtain anonymous testing. However, they should be informed that if they choose anonymous testing, no documentation of the results will be recorded in the medical chart, and their providers might have to retest them, potentially delaying provision of antiretoviral drugs for therapy or perinatal prophylaxis. Some women will continue to refuse testing, and their decisions should be respected. Before HIV testing, health-care providers should provide the following minimum information. Although a face-to-face counseling session is ideal, other methods can be used (e.g., brochure, pamphlet, or video) if they are culturally and linguistically appropriate. HIV is the virus that causes AIDS. HIV is spread through unprotected sexual contact and injection-drug use. Approximately 25% of HIV-infected pregnant women who are not treated during pregnancy can transmit HIV to their infants during pregnancy, during labor and delivery, or through breast-feeding. A woman might be at risk for HIV infection and not know it, even if she has had only one sex partner. Effective interventions (e.g., highly active combination antiretrovirals) for HIVinfected pregnant women can protect their infants from acquiring HIV and can prolong the survival and improve the health of these mothers and their children. For these reasons, HIV testing is recommended for all pregnant women. Services are available to help women reduce their risk for HIV and to provide medical care and other assistance to those who are infected. Women who decline testing will not be denied care for themselves or their infants. Health-care providers should perform HIV testing in consenting women as early as possible during pregnancy to promote informed and timely therapeutic decisions. Retesting in the third trimester, preferably before 36 weeks of gestation, is recommended for women known to be at high risk for acquiring HIV (e.g., those who have a history of sexually transmitted diseases [STDs], who exchange sex for money or drugs, who have multiple sex partners during pregnancy, who use illicit drugs, who have sex partner[s] known to be HIV-positive or at high risk, and who have signs and symptoms of seroconversion). Routine universal retesting in the third trimester may be considered in health-care facilities with high HIV seroprevalence among women of childbearing age. Retesting for syphilis during the third trimester and again at delivery also is recommended for pregnant women at high risk (83 ). Some states mandate syphilis screening at delivery for all pregnant women. Women admitted for labor and delivery with unknown or undocumented HIV status should be assessed promptly for HIV infection to allow for timely prophylactic treatment. Expedited testing by either rapid return of results from standard testing
MMWR
77
or use of rapid testing (with confirmation by a second licensed test when available) is recommended for these women. The goal is to identify HIV-infected women or their infants as soon as possible because the efficacy of prophylactic therapy is greatest if given during or as soon after exposure as possible (i.e., within 12 hours of birth). Informed consent is essential for women tested prenatally, and women in labor with unknown status should be allowed to refuse testing without undue consequences. After delivery, standard confirmatory testing should be done for women with positive rapid test results. Some women might not a) receive testing during labor and delivery, b) choose to be tested for HIV, or c) retain custody of their infants. If the mother has not been tested for HIV, she should be informed that knowing her infants infection status has benefits for the infants health and that HIV testing is recommended for her infant. Providers should ensure that the mother understands that a positive HIV antibody test for her infant indicates infection in herself. For infants whose HIV infection status is unknown and who are in foster care, the person legally authorized to provide consent should be informed that HIV testing is recommended for infants whose biological mothers have not been tested. Testing should be performed in accordance with the policies of the organization legally responsible for the child and with prevailing legal requirements for HIV testing of children. Regulations, laws, and policies regarding HIV screening of pregnant women and infants are not standardized throughout all states and U.S. territories. Health-care providers should be familiar with and adhere to state/local laws, regulations, and policies concerning HIV screening of pregnant women and infants.
78
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November 9, 2001
MMWR
79
positive HIV antibody test result and the need for and benefit of HIV-related medical and other early intervention services, including how to access these services. HIV-infected pregnant women should be counseled regarding antiretroviral therapy during pregnancy to improve their health (84 ) and prevent perinatal transmission (57 ). Medical care and management of HIV-infected persons, especially pregnant women, can be complicated because of the need for combination therapy with multiple drugs, management of common side effects, careful monitoring of viral load and drug resistance, prophylaxis for and treatment of opportunistic infections, and monitoring of immune status. Health-care providers who are not experienced in the care of pregnant HIV-infected women are encouraged to obtain referral for specialty care from providers who are knowledgeable in this area. Although pregnancy is not an adequate reason to defer therapy for HIV infection, unique considerations exist regarding use of antiretroviral drugs during pregnancy, including the potential need to alter dosing because of physiologic changes associated with pregnancy, the potential for adverse short- or long-term effects on the fetus and infant, and the effectiveness in reducing the risk for perinatal transmission (57 ). Obstetric providers should adhere to best obstetric practices, including offering scheduled cesarean section at 38 weeks to reduce risk for perinatal HIV transmission (60,85 ). HIV-infected pregnant women should receive information regarding all reproductive options. Reproductive counseling should be nondirective. Healthcare providers should be aware of the complex concerns that HIV-infected women must consider when making decisions regarding their reproductive options and should be supportive of any decision. To eliminate the risk for postnatal transmission, HIV-infected women in the United States should not breast-feed. Support services for use of appropriate breast milk substitutes should be provided when necessary. UNAIDS and World Health Organization recommendations for HIV and breast-feeding should be followed in international settings (86 ). To optimize medical management, positive and negative HIV test results should be available to a womans health-care provider and included on her confidential medical records and those of her infant. After informing the mother, maternal health-care providers should notify the pediatric-care providers of the impending birth of an HIV-exposed infant and any anticipated complications. If HIV is first diagnosed in the infant, health-care providers should discuss the implications for the mothers health and help her obtain care. Women should also be encouraged to have their other children tested for HIV. Children can be infected with HIV for many years before complications occur. Providers are encouraged to build supportive health-care relationships that promote discussion of pertinent health information. Confidential HIV-related information should be disclosed or shared only in accordance with prevailing legal requirements.
80
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November 9, 2001
After receiving their test results, HIV-infected pregnant women should receive counseling, including assessment of the potential for negative effects (e.g., discrimination, domestic violence, psychological difficulties). Counseling should also include information on how to minimize these consequences, assistance in identifying supportive persons in their own social networks, and referral to appropriate psychological, social, and legal services. HIV-infected women should be counseled regarding the risk for transmission to others and ways to decrease this risk. They also should be told that discrimination based on HIV status or AIDS in housing, employment, state programs, and public accommodations (including physicians offices and hospitals) is illegal. Health-care providers should thoroughly assess the prevention service needs of HIV-infected women (e.g., substance abuse, STD treatment, partner referral, or family planning services) and develop a plan to promote access to and use of these services (see Revised Guidelines for HIV Counseling, Testing, and Referral ). Health-care providers should follow the Public Health Service Task Force recommendations for using antiretroviral drugs to treat pregnant HIV-1 infected women and reduce perinatal HIV-1 transmission in the United States, which address treating pregnant women who do not receive health care until near the time of delivery. These recommendations are available at the HIV/AIDS Treatment Information Service (ATIS) website at <http://www.hivatis.org> (57 ).
Recommendations for Postpartum Follow-Up of Infected Women and Perinatally Exposed Children
HIV-infected women should receive ongoing HIV-related medical care, including immune-function monitoring, recommended therapy, and prophylaxis for and treatment of opportunistic infections and other HIV-related conditions (84,87 ). HIVinfected women should receive gynecologic care, including regular Pap smears, reproductive counseling, information on how to prevent sexual and drug-related transmission of HIV, and treatment of gynecologic conditions according to published recommendations (87 ). Obstetrical providers should ensure that HIVinfected women are introduced or referred to another provider to continue their care after pregnancy. HIV-infected women (or their childrens guardians) should be informed of the importance of follow-up for their children. Children whose HIV infection status is unknown require early diagnostic testing and prophylactic therapy to prevent PCP pending determination of their status. Infected children require follow-up care to determine the need for prophylactic therapy and antiretroviral treatment and to monitor disorders in growth and development that often occur before age 24 months. Uninfected children who are exposed to antiretroviral therapy should be assessed for potential short- and long-term side effects. Identification of an HIV-infected mother indicates that her family needs or will need medical and social services as her disease progresses. Thus, health-care providers should ensure that referrals to services address the needs of the entire family.
MMWR
81
CONCLUSION
Because of recent advances in both antiretroviral and obstetrical interventions, pregnant women infected with HIV who know their status prenatally can reduce their risk for transmitting HIV to their infants to <2%. The guidelines in this report are intended to reduce barriers to voluntary HIV testing for all pregnant women in the United States and to make the voluntary counseling and testing process simple and routine in prenatal settings. The recommendations underscore the importance of HIV-infected pregnant women (and their health-care providers) knowing their status to protect their own health and reduce the risk for transmitting HIV to their infants.
Acknowledgments We are grateful for the contributions of Ida Onorato, M.D., CDC.
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69. Koenig LJ, Moore J. Women, violence, and HIV: a critical evaluation with implications for HIV services. Matern Child Health J 2000;4:1039. 70. Americans with Disabilities Act. 42 USC section 12101 et seq. Available at <http:// www.usdoj.gov/crt/ada/adahom1.htm>. Accessed August 2, 2001. 71. George JR, Schochetman G. Detection of HIV infection using serologic techniques. In: Schochetman G, George JR, eds. AIDS testing: a comprehensive guide to technical, medical, social, legal, and management issues. 2 ed. New York, NY: Springer-Verlag, 1994. 72. Celum CL, Coombs RW, Lafferty W, et al. Indeterminate human immunodeficiency virus type 1 Western blots: seroconversion risk, specificity of supplemental tests, and an algorithm for evaluation. J Infect Dis 1991;164;65664. 73. Celum CL, Coombs RW, Jones M, et al. Risk factors for repeatedly reactive HIV-1 EIA and indeterminate Western blots: a population-based case-control study. Arch Intern Med 1994;154:112937. 74. Gwinn M, Redus MA, Granade TC, Hannon WH, George JR. HIV-1 serologic test results for one million newborn dried-blood specimens: assay performance and implications for screening. J Acquir Immune Defic Syndr 1992;5:50512. 75. MacDonald KL, Jackson JB, Bowman RJ, et al. Performance characteristics of serologic tests for human immunodeficiency virus type 1 (HIV-1) antibody among Minnesota blood donors: public health and clinical implications. Ann Intern Med 1989;110:61721. 76. Burke DS, Brundage JF, Redfield RR, et al. Measurement of the false positive rate in a screening program for human immunodeficiency virus infections. N Engl J Med 1988;319:9614. 77. Sheon AR, Fox HE, Alexander G, et al. Misdiagnosed HIV infection in pregnant women: implications for clinical care. Public Health Rep 1994;109:6949. 78. Branson BM. Rapid tests for HIV antibody. AIDS Rev 2000;2:7683. 79. Irwin K, Olivo N, Schable CA, Weber T, Janssen R, Ernst J, and the CDC-Bronx-Lebanon HIV Serosurvey Team. Performance characteristics of a rapid HIV antibody assay in a hospital with a high prevalence of HIV infection. Ann Intern Med 1996;125:4715. 80. Stetler HC, Granade TC, Nunez CA, et al. Field evaluation of rapid HIV serologic tests for screening and confirming HIV-1 infection in Honduras. AIDS 1997;11:36975. 81. Bulterys M, Fowler MG. Prevention of HIV infection in children. Pediatr Clin North Am 2000;47:24160. 82. Minkoff H, OSullivan MJ. The case for rapid HIV testing during labor. JAMA 1998;279:17434. 83. CDC. 1998 guidelines for treatment of sexually transmitted diseases. MMWR 1998;47(No. RR-1):1118. 84. Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents. January 2000. HIV/AIDS Treatment Information Service (ATIS) website at <www.hivatis.org>. Accessed August 10, 2001. 85. American College of Obstetricians and Gynecologists. Human immunodeficiency virus screening. Joint statement of the American Academy of Pediatrics and the American College of Obstetricians an Gynecologists. Pediatrics 1999;104:128. 86. WHO Technical Consultation on Behalf of the UNFPA/UNICEF/WHO/UNAIDS Inter-Agency Task Team on Mother-to-Child Transmission of HIV. New data on the prevention of motherto-child transmission of HIV and their policy implications. October 2000. Available at <http://www.unaids.org/publications/documents/mtct/index.html>. Accessed August 16, 2001. 87. CDC. 1999 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus. MMWR 1999;48(No. RR-10):166.
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INSTRUCTIONS
By Internet 1. Read this MMWR (Vol. 50, RR-19, Revised Recommendations for HIV Screening for Pregnant Women ), which contains the correct answers to the questions beginning on the next page. 2. Go to the MMWR Continuing Education Internet site at <http://www.cdc.gov/mmwr/cme/conted.html>. 3. Select which exam you want to take and select whether you want to register for CME, CEU, or CNE credit. 4. Fill out and submit the registration form. 5. Select exam questions. To receive continuing education credit, you must answer all of the questions. Questions with more than one correct answer will instruct you to Indicate all that apply. 6. Submit your answers no later than Novemeber 9, 2004. 7. Immediately print your Certificate of Completion for your records. By Mail or Fax 1. Read this MMWR (Vol. 50, RR-19, Revised Recommendations for HIV Screening for Pregnant Women ), which contains the correct answers to the questions beginning on the next page. 2. Complete all registration information on the response form, including your name, mailing address, phone number, and e-mail address, if available. 3. Indicate whether you are registering for CME, CEU, or CNE credit. 4. Select your answers to the questions, and mark the corresponding letters on the response form. To receive continuing education credit, you must answer all of the questions. Questions with more than one correct answer will instruct you to Indicate all that apply. 5. Sign and date the response form or a photocopy of the form and send no later than November 9, 2004, to Fax: 404-639-4198 Mail: MMWR CE Credit Office of Scientific and Health Communications Epidemiology Program Office, MS C-08 Centers for Disease Control and Prevention 1600 Clifton Rd, N.E. Atlanta, GA 30333 6. Your Certificate of Completion will be mailed to you within 30 days.
ACCREDITATION
Continuing Medical Education (CME). CDC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. CDC designates this educational activity for a maximum of 1.5 hours in category 1 credit toward the AMA Physicians Recognition Award. Each physician should claim only those hours of credit that he/she actually spent in the educational activity. Continuing Education Unit (CEU). CDC has been approved as an authorized provider of continuing education and training programs by the International Association for Continuing Education and Training and awards 0.1 hour Continuing Education Units (CEUs). Continuing Nursing Education (CNE). This activity for 1.7 contact hours is provided by CDC, which is accredited as a provider of continuing education in nursing by the American Nurses Credentialing Centers Commission on Accreditation.
CE2-19a2
MMWR
November 9, 2001
To receive continuing education credit, please answer all of the following questions.
1.
The recommended testing strategy for pregnant women can best be described as A. B. C. D. universal counseling and voluntary HIV testing. routine counseling and targeted testing. voluntary counseling and testing. targeted counseling and testing.
2.
The new guidelines differ from the 1995 guidelines for HIV counseling and testing for pregnant women in all of the following ways except A. B. C. D. E. making the consent process more flexible. strengthening the recommendation that all pregnant women be tested for HIV. placing more emphasis on HIV testing and treatment at the time of delivery. recommending simplification of the testing process. none of the above.
3.
All of the following factors have been associated with increased risk for perinatal HIV transmission except A. B. C. D. E. advanced maternal HIV disease. prolonged rupture of membranes. scheduled cesarean delivery. preterm delivery. maternal infection with another sexually transmitted disease (STD).
4.
All of the following are reasons commonly cited by women for declining HIV testing except A. B. C. D. E. no perceived risk. financial constraints. administrative scheduling difficulties. lack of provider endorsement. history of previous testing.
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CE3-19a2
Which of the following are included as one of the components of the recommended Pediatric AIDS Clinical Trials Group protocol 076 regimen for administration of zidovudine (ZDV)? A. B. C. D. Administration of oral ZDV to the infant for the first 8 weeks of life. Administration of oral ZDV to the mother beginning during the first trimester. Administration of intravenous ZDV to the infant at time of birth. Administration of intravenous ZDV during labor and delivery.
6.
All of the following information should be provided to pregnant women before HIV testing except A. B. C. D. E. Effective interventions can help protect infants from becoming infected. Services are available to help women reduce their risk for HIV. A woman might be at risk for HIV and not know it. Repeat HIV testing is not recommended for women tested within the year. HIV can be transmitted through breast-feeding.
7.
Retesting for HIV in the third trimester is recommended for A. B. C. D. women with a history of STDs. women with multiple sex partners during pregnancy. A and B. none of the above.
8.
Informed consent before HIV testing is A. B. C. D. optional. mandated by federal law. essential. required by most states.
9.
Indicate your work setting. A. B. C. D. E. F. State/local health department. Other public health setting. Hospital clinic/private practice. Managed care organizations. Academic institution. Other.
10. Which best describes your professional activities? A. B. C. D. E. F. Patient care emergency/urgent care department. Patient care inpatient. Patient care primary-care clinic or office. Laboratory/pharmacy. Public health. Other.
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November 9, 2001
11. I plan to use these recommendations as the basis for . . . (Indicate all that apply.) A. B. C. D. E. health education materials. insurance reimbursement policies. local practice guidelines. public policy. other.
12. Each month, approximately how many pregnant patients/clients do you see? A. B. C. D. E. None. 110. 1130. 3050. >50.
13. How much time did you spend reading this report and completing the exam? A. B. C. D. E. Fewer than 1.5 hours. More than 1.5 hours but fewer than 2 hours. 11.5 hours. More than 2.5 hours but fewer than 3 hours. 3 hours or more.
14. After reading this report, I am confident I can describe the recommended HIV counseling and testing strategy for pregnant women. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
15. After reading this report, I am confident I can identify risk factors for perinatal HIV transmission. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
MMWR
CE5-19a2
16. After reading this report, I am confident I can identify barriers to HIV testing among pregnant women. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
17. After reading this report, I am confident I can describe the information that pregnant women should receive before HIV testing. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
18. The objectives are relevant to the goal of this report. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
19. Overall, the presentation of the report enhanced my ability to understand the material. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
20. The recommendations will affect my practice. A. B. C. D. E. Strongly agree. Agree. Neither agree nor disagree. Disagree. Strongly disagree.
CE6-19a2
MMWR
November 9, 2001
21. How did you learn about this continuing education activity? A. B. C. D. E. F. Internet. Advertisement (e.g., fact sheet, MMWR cover, newsletter, or journal). Coworker/supervisor. Conference presentation.
MMWR subscription.
Other.
MMWR
CE7-19a2
MMWR Response Form for Continuing Education Credit November 9, 2001/Vol. 50/No. RR-19a2
Revised Recommendations for HIV Screening for Pregnant Women
To receive continuing education credit, you must 1. provide your contact information; 2. indicate your choice of CME, CEU, or CNE credit; 3. answer all of the test questions; 4. sign and date this form or a photocopy; 5. submit your answer form by November 9, 2004. Failure to complete these items can result in a delay or rejection of your application for continuing education credit.
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The Morbidity and Mortality Weekly Report (MMWR) Series is prepared by the Centers for Disease Control and Prevention (CDC) and is available free of charge in electronic format and on a paid subscription basis for paper copy. To receive an electronic copy on Friday of each week, send an e-mail message to listserv@listserv.cdc.gov. The body content should read SUBscribe mmwr-toc. Electronic copy also is available from CDCs World-Wide Web server at http://www.cdc.gov/mmwr/ or from CDCs file transfer protocol server at ftp://ftp.cdc.gov/pub/Publications/mmwr/. To subscribe for paper copy, contact Superintendent of Documents, U.S. Government Printing Office, Washington, DC 20402; telephone (202) 512-1800. Data in the weekly MMWR are provisional, based on weekly reports to CDC by state health departments. The reporting week concludes at close of business on Friday; compiled data on a national basis are officially released to the public on the following Friday. Address inquiries about the MMWR Series, including material to be considered for publication, to: Editor, MMWR Series, Mailstop C-08, CDC, 1600 Clifton Rd., N.E., Atlanta, GA 30333; telephone (888) 232-3228. All material in the MMWR Series is in the public domain and may be used and reprinted without permission; citation as to source, however, is appreciated.
2002-733-100/49019 Region IV