2 Penicillins
2 Penicillins
2 Penicillins
Penicillins
Lec. 2
Classification of Penicillins
1. Natural penicillins
A. Penicillin G (benzyl penicillin). Penicillin G is susceptible to
inactivation by β-lactamases (penicillinases). It is used in therapy
for infections caused by:
• Gram + ve cocci, e.g: Streptococcus.
• Gram +ve bacilli,e.g: Bacillus anthracis
• Gram – ve cocci, e.g: Neisseria.
• Anaerobic organisms, e.g: Clostridium.
B. Penicillin V has a spectrum similar to that of penicillin G. Penicillin
V is more acid-stable than penicillin G, It is often employed orally in
the treatment of infections.