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    Natural History of Disease

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    PRATIK SHRESTHA
    Natural history of disease refers to the progression of a disease over time from its earliest stage through recovery, disability, or death without treatment. Each disease has its own unique natural history. The stages include pre-pathogenesis when the disease agent is present but has not yet interacted with the host, pathogenesis when the agent enters the host and causes changes, and the final outcome of recovery, disability, or death. Understanding the natural history is important for public health practices and prevention strategies tailored to different disease stages.

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    Natural History of Disease

    Uploaded by

    PRATIK SHRESTHA
    19 views17 pages
    Natural history of disease refers to the progression of a disease over time from its earliest stage through recovery, disability, or death without treatment. Each disease has its own unique natural history. The stages include pre-pathogenesis when the disease agent is present but has not yet interacted with the host, pathogenesis when the agent enters the host and causes changes, and the final outcome of recovery, disability, or death. Understanding the natural history is important for public health practices and prevention strategies tailored to different disease stages.

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    3. Natural History of Disease

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    Natural history of disease refers to the progression of a disease over time from its earliest stage through recovery, disability, or death without treatment. Each disease has its own unique natural history. The stages include pre-pathogenesis when the disease agent is present but has not yet interacted with the host, pathogenesis when the agent enters the host and causes changes, and the final outcome of recovery, disability, or death. Understanding the natural history is important for public health practices and prevention strategies tailored to different disease stages.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    19 views17 pages

    Natural History of Disease

    Uploaded by

    PRATIK SHRESTHA
    Natural history of disease refers to the progression of a disease over time from its earliest stage through recovery, disability, or death without treatment. Each disease has its own unique natural history. The stages include pre-pathogenesis when the disease agent is present but has not yet interacted with the host, pathogenesis when the agent enters the host and causes changes, and the final outcome of recovery, disability, or death. Understanding the natural history is important for public health practices and prevention strategies tailored to different disease stages.

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    Natural History of Disease

    Ram Shrestha
    Principal
    NAMS College
    Natural History of Disease
    • Natural History is the way of disease
    development process in which a disease
    progress over time from the earliest stage of pre-
    pathogenesis to its termination as recovery or
    disability or death in the absence of treatment or
    prevention.
    • Each disease has its own unique natural history
    and that is not necessarily the same in all
    individuals.
    1. Pre-pathogenesis: It refers the period
    preliminary to the onset of disease process in
    man (i.e. the disease process in the
    environment). The disease agent yet to enter in
    man but the factors which favor its interaction
    with the human host are already existed in the
    environment. The condition is frequently
    referred as “man in the midst of disease” or
    “man exposed to the risk of diseases”
    • Potentially, we all are in the pre-pathogenesis
    phase of many disease both communicable
    and non-communicable.
    • The mere presences of agent, host and
    favorable environment factors in the pre-
    pathogenesis stage is not sufficient to start
    disease.
    • To initiate the disease process, there is need to
    interaction the three factors - agent, host and
    environment.
    2. Pathogenesis Phase:
    • The pathogenesis phase starts with the entry of
    disease agents in the susceptible human host.
    • The pathogenesis is clear-cut in infectious
    diseases. The disease agent multiplies and
    induces the tissues and physiological changes
    • The disease progress through the period
    incubation and latter early and late
    pathogenesis
    • The final outcome of the disease is the
    recovery, disability or death
    • The pathogenesis phase can be modified with
    immunization or other preventive measures or
    chemotherapy .
    • In this state, the host’s reaction with infection is
    not predictable. The infection may be clinical or
    sub-clinical, typical or atypical or the host may
    be a carrier or having without clinical disease.
    • In chronic disease like coronary heart disease,
    hypertension, cancer the early pathogenesis
    phase is pre-symptomatic or there is no visible
    of disease. The pathological changes are below
    the level of “clinical horizon”
    • The clinical stage begins with recognizable
    signs and symptoms appear. The disease phase
    already well advanced into the late
    pathogenesis phase.
    Importance
    • The natural history of
    disease is important in public health, because
    it provides a framework for prevention. Sound
    and effective public health practice links
    specific kinds of prevention to different states
    or stages of a disease's progress in an
    individual or a population.

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