Inotropic Agents.
Inotropic Agents.
Inotropic Agents.
Cardiac action
Extracardiac action
Cardiac action
• Positive inotropic
• Positive bathmotropic
• Negative chronotropic
• Negative dromotropic
Cardiac Glycosides
MECHANISM OF CARDIOTONIC (POSITIVE
INOTROPIC) ACTION Of CG
• Diuretic
• Sedative
• Stimulating influence on
smooth muscles
MODE of ACTION of CG IN CASE OF CHF
Warning!
• “dig toxicity”
– Systemic accumulation
Intoxication with CG
Happens frequently -
6-23 %
Mortality -
over 40 %
Intoxication with CG
Drug List
Agents for CHF
Vasodilators
• milrinone (Primacor)
• nitroprusside (Nitropress)
ACE Inhibitors