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    Olkimmilo - Protein Synthesis Inhibitors - BW

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    hediye
    This document provides a summary of various protein synthesis inhibitors including tetracyclines, macrolides, ketolides, aminoglycosides, and others. It lists the indications, pharmacokinetics, gastrointestinal side effects, and other key information about these drug classes and selected agents in a concise cheat sheet format.

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    Olkimmilo - Protein Synthesis Inhibitors - BW

    Uploaded by

    hediye
    29 views2 pages
    This document provides a summary of various protein synthesis inhibitors including tetracyclines, macrolides, ketolides, aminoglycosides, and others. It lists the indications, pharmacokinetics, gastrointestinal side effects, and other key information about these drug classes and selected agents in a concise cheat sheet format.

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    This document provides a summary of various protein synthesis inhibitors including tetracyclines, macrolides, ketolides, aminoglycosides, and others. It lists the indications, pharmacokinetics, gastrointestinal side effects, and other key information about these drug classes and selected agents in a concise cheat sheet format.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    29 views2 pages

    Olkimmilo - Protein Synthesis Inhibitors - BW

    Uploaded by

    hediye
    This document provides a summary of various protein synthesis inhibitors including tetracyclines, macrolides, ketolides, aminoglycosides, and others. It lists the indications, pharmacokinetics, gastrointestinal side effects, and other key information about these drug classes and selected agents in a concise cheat sheet format.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    PROTEIN SYNTHESIS INHIBITORS Cheat Sheet

    by olkimmilo via cheatography.com/42456/cs/12777/

    TETRAC​YCLINES MACROL​IDE​S/K​ETO​LIDES (cont)

    Indications Ricket​tsial infections (rocky mountain spotted fever), TELITH​R Effective against macrol​ide​-re​sistant organisms
    chlamydia, lyme disease, mycopl​asmal infect​ions, chronic OMYCIN
    severe acne, cholera, gastri​c/d​uodenal ulcer caused by H. Indi​cat​ions: respir​atory tract infect​ions, including
    pylori commun​ity​-ac​quired bacteria pneumonia, acute

    PK Excreted in bile, urine, breast milk, undergo entero​hepatic exacer​bations of chronic bronch​itis, sinusitis and strepto
    circul​ation pharyn​gitis

    GI GI, deposition of drug in bones and teeth, liver failure, Indi​cat​ions: community acquired pneumonia (mycop​lasma, legion​ella,
    photot​oxi​city, vertigo, avoid in pregnant chlamy​dia), pertussis, campyl​obacter jejuni gastro​ent​eritis, MAC
    (azalides)
    TETRAC​YCLINES
    PK: Well distri​buted, CNS penetr​ation limited except with inflam​mation.
    SHORT CHLORTETRACYCLINE
    Most of drug is concen​trated in the liver and excreted in the bile, some
    TETRAC​YCLINE inacti​vated in the liver by demeth​yla​tion.

    OXYTETRACYCLINE
    AE: GI, jaundice, ototox​icity
    INTERM​ DEMECLOCYCLINE treats SIADH
    EDIATE
    Bacter​ios​tatic, bacter​icidal at high doses
    METHAC​YCLINE

    LONG DOXYCY​CLINE treat infections in pts with anuria OTHERS


    (elimi​nates via bile, feces)
    CLINDA​MYCIN Indi​cat​ions: pencil​lin​-re​sistant anaerobic
    MINOCY​CLINE achieves high CNS concen​tra​tions in
    infections
    the absence of inflam​mation,
    Clinical use: SSTI
    metabo​lized in liver
    Phar​mac​olo​gy: high bone concen​tra​tions
    Toxi​city: diarrhea, allergy, skin rashes,
    MACROL​IDE​S/K​ETO​LIDES
    pseudo​mem​branous colitis caused by
    AZITHROMYCIN show cross-​res​istance with erythr​omycin overgrowth of C. diff
    longest t1/2 CHLORAMPHENICOL Indi​cat​ions: Ricket​tsiae (typhus and Rocky
    Mountain spotted fever); bacterial meningitis
    Adva​nta​ges: less GI distur​bances
    Clinical use: eye infections
    CLARITHROMYCIN show cross-​res​istance with erythr​omycin AE: GI distur​bances, gray baby syndrome,
    aplastic anemia
    Adva​nta​ge: lower incidence of GI distur​bances, PEARL: Because of its toxicity and resist​ance,
    less frequent dosing its use is restricted to life-t​hre​atening infections

    ERYTHR​OMYCIN MOA: Interferes with aminoacyl transl​oca​tion, for which no altern​ative exists

    preventing the transfer of the tRNA bound at the A


    site of the 50S rRNA complex to the P site of the STREPT​OGR​AMINS
    rRNA complex
    QUINUP​RIS​TIN​- AE: venous irrita​tion, athralgia and myalgia,
    DA​LFO​PRISTIN hyperb​ili​rub​inemia
    Destroyed by gastric acid and must be enteric
    coated
    OXAZOL​IDI​NONES
    shortest t1/2
    LINEZOLIDE PK: completely absorbed, widely distri​buted throughout
    the body, excreted renally and non-re​nally
    AE: GI upset

    By olkimmilo Published 11th September, 2017. Sponsored by Readability-Score.com


    cheatography.com/olkimmilo/ Last updated 11th September, 2017. Measure your website readability!
    Page 1 of 2. https://readability-score.com
    PROTEIN SYNTHESIS INHIBITORS Cheat Sheet
    by olkimmilo via cheatography.com/42456/cs/12777/

    AMINOG​LYC​OSIDES AMINOG​LYC​OSIDES (cont)

    STREPTOMYCIN 2nd line agent for the treatment of tuberc​ulosis in SPECTI​N Indi​cat​ions: altern​ative treatment for drug-r​esi​stant
    combin​ation with other agents to prevent emergence OMYCIN gonorrhea or gonorrhea in pcn-al​lergic pts
    of resistance No cross-​res​istance with other drugs used in gonorrhea
    AE: vestibular distur​bances AE: pain at injection site, fever, nausea

    GENTAMICIN Intrat​hecal AE: Otot​oxi​city (rever​sible), neph​rot​oxi​city (rever​sible),


    Indi​cat​ions: mainly used in combo for severe neurom​uscular blockade
    infections (sepsis and pneumonia) caused by
    resistant strains of gram negative bacteria, infected PK: Levels in most tissue are low. No CNS penetr​ation. High
    burns/​wou​lds​/le​sions, prevention of catheter accumu​lation in renal cortex and lymph of inner ear. Excreted into the
    infections urine by glomerular filtra​tion. Accumu​lation occurs in patients with renal
    GENT+B​- Synerg​istic effect against pseudo​monas, proteus, failure, not metabo​lized
    LACTAM entero​bacter, klebsi​ella, serratia, stenot​rop​hom​onas,
    and other gram negative rods that are resistant to Used against aerobic gram negative bacilli
    multiple antibi​otics Exhibit concen​tra​tio​n-d​epe​ndent killing
    Postan​tib​iotic effect
    TOBRAMYCIN Inhalation
    Cautioned in pts with preexi​sting renal, vestibular or
    hearing disorders

    STREPTO+PCN Used for tuleremia and entero​coccal carditis

    KANAMYCIN Kanamy​cin​-re​sistant strains may be cross-​res​istant to


    (topical only) amikacin

    AMIKACIN Semisy​nthetic derivative of kanamycin, less toxic


    Indi​cat​ions: tx microo​rga​nisms resistant to
    gentamicin and tobramycin

    NEOMYCIN Indi​cat​ions: reduce the risk of infections during


    (topical only) bowel surgery

    By olkimmilo Published 11th September, 2017. Sponsored by Readability-Score.com


    cheatography.com/olkimmilo/ Last updated 11th September, 2017. Measure your website readability!
    Page 2 of 2. https://readability-score.com

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