Fundamentals of Pharmacology 8th Edition Bullock Test Bank
Fundamentals of Pharmacology 8th Edition Bullock Test Bank
Fundamentals of Pharmacology 8th Edition Bullock Test Bank
Topics:
Pain
Opioid analgesics
Opioid antagonists
Learning objective:
1. Describe the classification, physiology and assessment of pain.
2. Describe the mechanisms of action, adverse effects and clinical considerations of the opioid analgesics.
3. Outline the uses and clinical considerations of the opioid receptor antagonists.
MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question.
9) The reason that methadone is used to help wean people off heroin is that:
A) methadone has a long half-life, which contributes to weak withdrawal symptoms.
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B) methadone is administered orally, reducing syringe use.
C) methadone binds to opioid receptors, leaving few receptors available for a heroin ‘high’.
D) all of the above.
Answer: D
Topic: Opioid analgesics
Learning objective: 2 Describe the mechanisms of action, adverse effects and clinical consideration of the opioid analgesics.
Difficulty: 1
Learning objective:
1. Outline the physiological roles of prostaglandins and their biosynthesis.
2. Describe the mechanisms of action, common adverse effects, and clinical considerations of the non-steroidal anti-
inflammatory drugs (NSAIDs).
3. Describe the classification of the NSAIDs and miscellaneous analgesic agents.
4. Describe the mechanism of action, common adverse effects, and clinical considerations of paracetamol.
5. Outline the types of medicines used in the management of rheumatoid arthritis.
2) The combined use of salicylates and corticosteroids may lead to ________ and should therefore be avoided.
A) tinnitus
B) renal failure
C) peptic ulceration
D) liver failure
Answer: C
Topic: Non-steroidal anti-inflammatory drugs (nsaids)
Learning objective: 2 Describe the mechanisms of action, common adverse effects, and clinical considerations of the non-steroidal
anti-inflammatory drugs (NSAIDs).
Difficulty: 2
3) Controlled-release preparations of ketoprofen should be taken ________ to improve the symptoms of arthritic pain.
A) immediately after meals
B) 15 minutes before physical activity
C) at bedtime
D) upon rising in the morning
Answer: C
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Topic: Non-steroidal anti-inflammatory drugs (nsaids)
Learning objective: 2 Describe the mechanisms of action, common adverse effects, and clinical considerations of the non-steroidal
anti-inflammatory drugs (NSAIDs).
Difficulty: 2
4) The propionic acid derivatives ibuprofen and naproxen are useful for children suffering from inflammatory disease because
they:
A) are not metabolised in the liver.
B) do not cause gastrointestinal problems.
C) are available as oral liquids so that the exact dose can be administered.
D) do not affect platelet aggregation.
Answer: C
Topic: Non-steroidal anti-inflammatory drugs (nsaids)
Learning objective: 2 Describe the mechanisms of action, common adverse effects, and clinical considerations of the non-steroidal
anti-inflammatory drugs (NSAIDs).
Difficulty: 2
5) Aspirin needs to be stopped approximately ________ before planned surgery and some complex dental procedures because of
the possibility of increased bleeding.
A) two days
B) seven days
C) two weeks
D) seven weeks
Answer: B
Topic: Non-steroidal anti-inflammatory drugs (nsaids)
Learning objective: 2 Describe the mechanisms of action, common adverse effects, and clinical considerations of the non-steroidal
anti-inflammatory drugs (NSAIDs).
Difficulty: easy
6) NSAIDs may not be suitable for use in individuals with renal impairment because they:
A) increase sodium excretion.
B) increase body temperature.
C) reduce the glomerular filtration rate.
D) reduce pepsin levels in the stomach.
Answer: C
Topic: Non-steroidal anti-inflammatory drugs (nsaids)
Learning objective: 2 Describe the mechanisms of action, common adverse effects, and clinical considerations of the non-steroidal
anti-inflammatory drugs (NSAIDs).
Difficulty: 3
7) Extreme diligence should be exercised in administering the correct dose of paracetamol to children because overdose can lead
to:
A) gastrointestinal bleeding.
B) renal failure.
C) inhibition of the hypothalamic control on temperature.
D) liver damage.
Answer: D
Topic: Paracetamol
Learning objective: Describe the mechanisms of action, common adverse effects, and clinical considerations of paracetamol.
Difficulty: 1
Topics:
Migraine pathophysiology
Treatment of acute attacks of migraine
Migraine prophylaxis
Learning objective:
1. Describe the pathophysiology of migraine.
2. Explain the treatments used for acute attacks of migraine.
3. Explain the treatments used for preventing migraine attacks.
1) Analgesic agents that are effective in treating mild to moderate acute migraine headaches include:
A) ibuprofen and indomethacin.
B) aspirin and paracetamol.
C) piroxicam and sulindac.
D) propranolol and ketamine.
Answer: B
Topic: Treatment of acute attacks of migraine
Learning objective: 2 Explain the treatments used for acute attacks of migraine.
Difficulty: 2
4) In treating an acute migraine attack, sumatriptan should not be given with ergotamine because the combination may lead to:
A) excessive bronchoconstriction.
B) excessive vasoconstriction.
C) gastrointestinal bleeding.
D) excessive diuresis.
Answer: B
Topic: Treatment of acute attacks of migraine
Learning objective: 2 Explain the treatments used for acute attacks of migraine.
Difficulty: 2
1) Which of the following is NOT a contraindication for the use of nitrous oxide as an inhalational anaesthetic?
A) Pneumothorax
B) Surgical procedures involving the middle ear
C) Tachycardia
D) Intestinal obstruction
Answer: C
Topic: Mechanism of action of general anaesthetics
Learning objective: 2 Outline the possible mechanisms of action of the general anaesthetics.
Difficulty: 3
2) The rate of absorption of inhaled anaesthetic into the bloodstream is dependent on the ________ of the gas.
A) rate of osmosis
B) partial pressure
C) volume
D) surfactant levels
Answer: B
Topic: Mechanism of action of general anaesthetics
Learning objective: 2 Outline the possible mechanisms of action of the general anaesthetics.
Difficulty: 3
Learning objective:
1. Outline the phases of the action potential in peripheral nerves.
2. Describe the general characteristics of local anaesthetics, highlighting the characteristics of some common local
anaesthetics.
1) The mechanism of action of the local anaesthetics is to impede the movement of which ion through its membrane channels?
A) Calcium
B) Potassium
C) Sodium
D) GABA
Answer: C
Topic: Local anaesthetics
Copyright ©2017 Pearson Australia (a division of Pearson Australia Group Pty Ltd) – 9781488610028/Bullock/Fundamentals of Pharmacology/8e
Learning objective: 1 1 Outline the phases of the action potential in peripheral nerves.
Difficulty: 3
2) Which of the following routes of administration has the highest rate of systemic absorption of local anaesthetic agents?
A) Epidural administration
B) Intercostal administration
C) Subcutaneous administration
D) Brachial plexus administration
Answer: B
Topic: Local anaesthesia
Learning objective: 2 2 Describe the general characteristics of local anaesthetics, highlighting the characteristics of some common
local anaesthetics.
Difficulty: 3
3) Which of the following local anaesthetics has a relatively long duration of action?
A) Procaine
B) Lignocaine
C) Bupivacaine
D) Mepivacaine
Answer: C
Topic: Local anaesthesia
Learning objective: 2 Describe the general characteristics of local anaesthetics, highlighting the characteristics of some common
local anaesthetics
Difficulty: 2
Copyright ©2017 Pearson Australia (a division of Pearson Australia Group Pty Ltd) – 9781488610028/Bullock/Fundamentals of Pharmacology/8e