Taxonomía: Parvoviridae
Taxonomía: Parvoviridae
Taxonomía: Parvoviridae
Abstract
Members of the family Parvoviridae are small, resilient, non-enveloped viruses with linear, single-stranded DNA genomes of
4–6 kb. Viruses in two subfamilies, the Parvovirinae and Densovirinae, are distinguished primarily by their respective ability to
infect vertebrates (including humans) versus invertebrates. Being genetically limited, most parvoviruses require actively
dividing host cells and are host and/or tissue specific. Some cause diseases, which range from subclinical to lethal. A few
require co-infection with helper viruses from other families. This is a summary of the International Committee on Taxonomy
of Viruses (ICTV) Report on the Parvoviridae, which is available at www.ictv.global/report/parvoviridae.
Typical member: human parvovirus B19-J35 G1 (AY386330), species Primate erythroparvovirus 1, genus Erythroparvovirus, subfamily
Parvovirinae
VIRION GENOME
Viruses package a single copy of a linear ssDNA molecule of
Parvovirus virions are small, rugged, non-enveloped
4–6 kb, which contains a long coding region bracketed by
protein particles with T=1 icosahedral symmetry
short (120–600 nt) dynamic hairpin termini that mediate
(Table 1 and Fig. 1). A single coat protein sequence is DNA replication (Fig. 2). Packaged strands can be of negative
expressed as a nested set of virion proteins (VP) with or both senses. Two gene cassettes encode a
a common C-terminal domain that forms the virion replication initiator protein (NS1 or Rep) and a virion protein
shell. VP1 N-termini may have phospholipase A2 (VP), plus a few small genus-specific auxiliary proteins. Many
(PLA2) activity [1, 2]. parvoviruses are highly specialized for infecting particular host
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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the
original work is properly cited.
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Cotmore et al., Journal of General Virology 2019;100:367–368
RESOURCES
FullICTV Report onthe family Parvoviridae:
www.ictv.global/report/parvoviridae.
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