STS Reviewer
STS Reviewer
STS Reviewer
RISKS RELATED TO THE USE OF GENETICALLY The early 2000’s saw the beginning of commercial
MODIFIED ORGANISMS (GMOs) applications of nanotechnology, although these
o Genetic Contamination/Interbreeding. - were limited to bulk applications of nanomaterial
Introduced GMOs may interbreed with the wildtype rather than the transformative applications
or sexually compatible relatives. The novel trait envisioned by the field.
may disappear in wild types unless it confers a Application of Nanotechnology in all fields of science
selective advantage to the recipient. However, - Electronics. Single electron transistor (SET), spin
tolerance abilities of wild types may also develop, valves and magnetic tunnel junctions (MT)s are
thus altering the native species’ ecological based on nanotechnology. Spin valve-type devices
relationship and behavior. are already being used in personal computers to
o Competition with Natural Species. - Faster “read discs,” which has enabled the increase of
growth of GMOs can enable them to have a data storage capacity of hard discs.
competitive advantage over the native organisms. - Energy. Carbon nanomaterial (CNM) has been
This may allow them become invasive, to spread used in improving the efficacy of lithium secondary
into new habitats, and cause ecological and batteries, supercapacitors and in hydrogen
economic damage. storage.
o Increased Selection Pressure on Target and - Environment. Nanomaterials-based sensors
Non-target Organisms. - Pressure may increase would be smart sensors, i.e., they will be able to
on target and non-target species to adapt to the detect and rectify problems. Such sensors are
introduced changes as if to a geological change or being developed for water purification systems,
detection of toxic ions, metal ions, pesticides, etc., 2. Gene transfer method
and their remediation on a larger scale. o There are 3 physical, chemical, and
- Automobiles. Nano sensors will help in assessing biological methods of gene transfer.
emissions from the vehicle and help in controlling 3. Gene transfer to specific cell line
pollutants. Car paints/coatings using nanoparticle o This line is divided into 2 general
are being used to provide smooth, thin attractive categories of somatic gene therapy, and
coatings that are scratch resistant, can repel dirt sex cell gene therapy.
and are anti-reflective. “Self-cleaning” glass for 4. The adoption of the most appropriate genetic
windows is being fabricated by dissolving a small engineering (gene injection)
amount of titania (TiO2) nanoparticles. o Other forms of genetic engineering include
- Agriculture and Food. Application in combating gene targeting and the elimination of
plant diseases: • Controlled delivery of functional specific genes through nuclease
molecules Nanoparticles used as Trojan horse for engineering.
delivery of active ingredients.
- Industries. Industries are involved in developing Stem Cell Therapy
and producing nanomaterials to obtain
nanobioproducts for bone substitutes and dentistry; A stem cell therapy is any treatment that uses stem
antimicrobial applications in various products; food cells as the primary way of curing or reducing the
and cosmetic applications; applications in textiles, severity of a disease or disorder. There are two
paints, catalysis, lubricants, fuel cells and batteries; main ways stem cells can be used:
all of which are part of major industrial production.
1. as a transplant, where the desired stem cells are
- Textiles. Special threads and dyes used in the
harvested either from the patient or a donor and
textile industry are products of nanotechnology.
refined or modified in some way before being
These clothes do not require ironing or frequent
injected or grafted into the patient, or
cleaning. Use of silver (Ag) nanoparticles in
2. as a target for a drug or other biologic where the
washing machines remove the germs from clothes
drug or biologic is intended to activate a desired
while washing. Masks made of fabrics coated with
response from the stem cells that already exist in
nanoparticles for protection against microbes are
the patient’s tissues or organs.
already on the market.
- Cosmetics. Nanoliposomes are used as vesicular CHAPTER 11: Climate Change, Energy Crisis and
delivery systems. Liposomes are concentric bilayer Environmental Awareness
vesicles. The first liposomal cosmetic was the anti- Climate change is a broad range of global
aging cream “Capture” manufactured by Dior. phenomena created predominantly by burning
- Domestic Appliances. Nano porous aerogel fossil fuels, which add heat-trapping gases to
insulator is excellent for insulating walls. Flame- Earth’s atmosphere. These phenomena include the
retardant furniture coatings are on the market increased temperature trends described by global
which are synthesized carbon nanofibers. Fishing warming, but also encompass changes such as
rods are made stronger and lighter using silica sea level rise; ice mass loss; shifts in flower/plant
nanoparticles to fill spaces between carbon fibers. blooming; and extreme weather events.
- Diagnostics and Therapeutics. Nanomedicine On Earth, human activities are changing the
researchers are looking at ways that natural greenhouse. Over the last century the
nanotechnology can improve vaccines, including burning of fossil fuels like coal and oil has
vaccine delivery without the use of needles. increased the concentration of atmospheric carbon
Researchers also are working to create a universal dioxide (CO2).
vaccine scaffold for the annual flu vaccine that - Greenhouse gas emissions
would cover more strains and require fewer Evidence that CO2 emissions are the cause of
resources to develop each year. global warming is very robust.
- Environmental Aspects of Nanotechnology - Earth’s natural climate cycle
- Triclosan, commonly found in antimicrobial soaps Over the last 800,000 years, there have been
and cleaning products, is among many consumer- natural cycles in the Earth’s climate, between ice
used chemicals found in the river and drinking ages and warmer interglacial periods.
water sources. - Solar influences
- Antimicrobial resistance is a big problem because The sun is the primary source of Earth’s heat, so
bacteria are no longer susceptible to the relatively small changes in solar output can affect
treatments developed to kill them, and outbreaks our climate.
can occur that cannot be managed.
Impacts on Vulnerability and Equity
CHAPTER 10: Gene Therapy 1. Geographic Location
The genes in the body’s cells play an important • Population in coastal areas are more sensitive to
role in your health – indeed, a defective gene or storms, drought, air pollution and heat waves. •
genes can make someone sick. Population in mountainous areas will likely face
Cells are the basic building blocks of all living water shortages and increased wildfires in the
things. The human body is composed of trillions of future.
them. • Arctic residents will likely experience problems
In gene therapy, scientist can do one of several caused by thawing permafrost.
things depending on the problem that is present. 2. Ability to cope
Gene therapy can be used to modify cells inside or • People who live in poverty may have a difficult
outside the body. time coping with changes. These people have
limited financial resources to cope with heat,
In order to insert new genes directly into cells,
relocate or evacuate, or respond to increases in
scientists use a vehicle called a “vector” which is
the cost of food.
genetically engineered to deliver the gene.
• Older adults may be among the least able to cope
Approaches to Gene Therapy with impacts of climate change.
• Elderly people are particularly prone to heat
1. Gene Modification
stress.
o Researchers have used the following
• Young children are another sensitive age group,
methods to modify defective genes:
since their immune system and other bodily
Replacement treatment: Replacing a systems are still developing and they rely on others
natural gene with a non-natural gene to care for them in disaster situations.
through homologous recombination. 3. Indigenous people
Modifier gene therapy: Restoring natural • Climate change will make it harder for tribes to
function to a defective gene through access safe and nutritious food, including
selective reverse mutation. traditional foods important to many tribes’ cultural
Adjustment of the expression of a specific practices. Many tribes already lack access to safe
gene.
drinking water and wastewater treatment in their
communities.
4. Urban People
• City residents and urban infrastructure have
distinct sensitivities to climate change impacts. For
example, heat waves may be amplified in cities
because cities absorb more heat during the day
than suburban and rural areas. Cities are more
densely populated than suburban or rural areas.
5. Impacts on Economic Activities and Services
• Communities that developed around the
production of different agricultural crops, such as
corn, wheat or cotton, depend on the climate to
support their way of life.
• Climate change will also likely affect tourism and
recreational activities. A warming climate and
changes in precipitation patterns will likely
decrease the number of days when recreational
snow activities such as skiing and snowmobiling
can take place.
In 1992, the United Nations Framework Convention
on Climate Change (UNFCC) was adopted as the
basis for a global response to the problem. The
Philippines signed the UNFCCC on 12 June 1992
and ratified the international treaty on 2 August
1994. Presently, the Convention enjoys near
universal membership with 194 Country Parties.