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Hypnotic Drugs

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Hypnotic Drugs Overview

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Neil Tungbaban

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discuss the different hypnotic drugs

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Hypnotic drugs, also known as sleep aids or sleeping pills, are medications that are prescribed to
individuals experiencing sleep problems or insomnia. These drugs help induce sleep, improve sleep
quality, and increase the duration of sleep. Here are some commonly prescribed hypnotic drugs:

Benzodiazepines (BZDs): Benzodiazepines are a class of drugs that act as sedatives, anxiolytics, and
muscle relaxants. They are commonly used as hypnotics due to their sedating effects. Examples include
diazepam (Valium), lorazepam (Ativan), and temazepam (Restoril). These drugs work by enhancing the
activity of a neurotransmitter called gamma-aminobutyric acid (GABA), which has a calming effect on the
brain.

Non-Benzodiazepine Hypnotics: These drugs are similar in action to benzodiazepines but have a slightly
different chemical structure. They are often referred to as "Z-drugs" due to the generic names of some
common medications starting with the letter "Z." Examples include zolpidem (Ambien), zaleplon
(Sonata), and eszopiclone (Lunesta). These drugs bind to specific receptors in the brain that are
associated with sleep regulation.

Melatonin Receptor Agonists: Melatonin is a hormone that regulates the sleep-wake cycle. Melatonin
receptor agonists are medications that mimic the effects of melatonin in the brain. Examples include
ramelteon (Rozerem) and tasimelteon (Hetlioz). These drugs help regulate sleep by influencing the
body's internal clock and promoting the onset of sleep.

Orexin Receptor Antagonists: Orexin is a neuropeptide that plays a role in promoting wakefulness. Orexin
receptor antagonists, such as suvorexant (Belsomra), work by blocking the action of orexin in the brain,
thereby promoting sleep. These medications are relatively new and work through a different mechanism
compared to other hypnotics.

Antidepressants: Certain antidepressant medications, particularly those that have sedating properties,
can be prescribed as hypnotics. Examples include trazodone (Desyrel) and amitriptyline (Elavil). These
drugs can help improve sleep by reducing anxiety and promoting relaxation.

It's important to note that hypnotic drugs should be used under the guidance and supervision of a
healthcare professional. They can have side effects, including daytime drowsiness, dizziness, and the
potential for dependency or withdrawal symptoms. It is advisable to discuss the benefits and risks of
these medications with a healthcare provider to determine the most appropriate treatment option for
specific sleep issues.

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