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SPINE

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• Spinal Cord Anatomy

• Meninges cover the spinal cord


• Nerves leave at the level of each
vertebrae
• Dorsal root
• Associated with the dorsal root ganglia –
collections of cell bodies outside the central
nervous system

•Ventral root
• Peripheral Nervous System

• Nerves and ganglia outside the central


nervous system

• Nerve = bundle of neuron fibers

• Neuron fibers are bundled by


connective tissue
• Structure of a Nerve

• Endoneurium
surrounds each fiber

• Groups of fibers are


bound into fascicles
by perineurium

• Fascicles are bound


together by
epineurium
grey matter in the centre (the butterfly shape)
white matter surrounds it
opposite arrangement is found in the cortex of the brain..
•The diameter of the
spinal cord is the
largest in the cervical
region and there is a
larger proportion of
white matter
compared to gray
matter.
•The diameter of the sacral
region of the spinal cord
(which is surrounded by the
T12/L1 vertebrae) is the
smallest and the proportion of
gray matter is largest in the
spinal cord.
Cross Section of Spinal Cord
Cross Section of Spinal Cord

• White matter: • Gray matter:


• Myelinated axons • Neuron cell cell bodies,
dendrites, axons
forming nerve tracts
• ‘Horns’:
• Fissure and sulcus • Posterior (dorsal)
• Three columns: • Anterior (ventral)
• Ventral • Lateral

• Dorsal
• Lateral • Commissures:
• Gray: Central canal
• White
Functional Organization of the Nuclei
within the Gray Matter
of the Spinal Cord
Location of Ascending and
Descending Tracts of the Spinal Cord
•See ANS
•lecture
•The cervical
enlargement contains the
neurons that innervate the
upper limbs

•The lumbar
enlargement contains
the neurons that
innervate the lower
limbs.
•The tapering end
of the spinal cord is
called the conus
medullaris.

•The conus
medullaris is
surrounded by L1
in and adult and
L2 in a child.
•The adult spinal cord
terminates at the level of
the first lumbar vertebra
(L1)

•In a developing child,


the spinal cord can
extend to the level of
the second lumbar
vertebra (L2)
•The cauda
equina
(horse’s tail)
is composed
of nerves that
arise from
the conus
medullaris
and extend
inferiorly.
•The filum terminale,
which is composed of
pia mater, extends from
the conus medullaris to
the coccyx. Note the
subarachnoid space also
continues for some
distance.
•There are 31
pairs of spinal
nerves that
serve defined
segments of the
human body.
•‘Plexus’:
•intermingling /
merging of nerves
and subsequent re-
organisation
•--> distribution of
peripheral nerves
is different from
that of spinal
nerves
•The Organisation of the Nervous System

•spinal cord brain


•CNS
•spinal nerves (31p) cranial nerves (12p)

•PNS
•sensory motor •motor sensory

• Sensory information has to be passed on from the spinal cord to the brain
• ascending pathways (red)

• Commands from the brain have to be sent out to the PNS


• descending pathways (green)
•Ascending (afferent) spinal tracts:

• Pathways that carry sensory information to a conscious level

•receptor
•(e.g. pain receptor in skin)

• primary sensory neurone


•(cell body in dorsal root ganglia)

• second order neurone


•(in the spinal cord or brainstem)
• target area: cortex
• third order neurone •somatosensory (somatic sensory)
•(in thalamus)
area
•(postcentral gyrus) of the cortex
•Example

•Conscious
•perception

•Light touch
•Sensory information travels to the brain via 3 main pathways:

To somatosensory cortex
1) Spinothalamic system (lateral and anterior tract):
somatosensory information to brain:pain and temperature, light touch,
pressure, tickle, itch

2) Dorsal column / medial lemniscus:


Two-point discrimination, proprioception, pressure, vibration

To cerebellum:
3) Spinocerebellar system (posterior and anterior):
proprioception, for comparator function
Basic Organization of a
Reflex Pathway
Terms Associated with
Reflex Pathways

• Spinal Reflexes // Cranial Reflexes


• Somatic Reflexes // Visceral (Autonomic)
Reflexes
• Monosynaptic Reflex // Polysynaptic Reflex
• Ipsilateral Reflex // Contralateral Reflex
• Segmental Reflex // Intersegmental Reflex
• Reciprocal innervation
A Spinal, Somatic, Monosynaptic,
Ipsilateral, Segmental Reflex
demonstrating Reciprocal Innervation

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